Navigation Links
Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic// lymphocytic leukemia (B-CLL), the most common human leukemia in the world.

Their findings, published in the December 15 issue of Cancer Research, demonstrate that miRNAs are emerging as powerful regulators of gene expression in cancer development, and could offer new targets for drug treatment, the investigators say.

In this case, high levels of two miRNAs known as miR-29 and miR-181 seem to suppress expression of the TCL1 oncogene that drives the most aggressive forms of the leukemia, said the study’s lead author, Yuri Pekarsky, Ph.D., assistant professor in the Department of Molecular Virology, Immunology and Medical Genetics at Ohio State University’s Comprehensive Cancer Center.

“We have found a direct inverse association between expression of miR-29 and miR-181 and that of the TCL1 oncogene,” he said. “It works in both directions. High expression of these miRNAs correlates with low expression of TCL1, in the indolent form of cancer that is less likely to progress. A low level of miR-29 and miR-181 is associated with a much more aggressive cancer.”

Drugs that boost production of these two natural TCL1 inhibitors might work as a future treatment for B-cell chronic lymphocytic leukemia, he said. These molecules could also be combined with 12 other miRNAs known to be associated with B-CLL to provide a test that may help determine prognosis and treatment, he said.

Researchers at Ohio State have been leaders in characterizing the role of miRNAs in cancer development. These small molecules are single-stranded RNA molecules that can act either as tumor suppressors or oncogenes. They can block transcription of genes by stopping them from producing messenger RNA or can inhibit translation of the genes by blocking production of proteins f
'"/>




Page: 1 2

Related medicine news :

1. MicroRNA provides new insight into birth defects
2. Role Of MicroRNAs In Angiogenesis Researched
3. MicroRNAs Can Be Tumor Suppressors
4. Sensor Can Detect "Unhealthy" Molecules In Breath
5. Protein Molecules in blood predict preeclampsia development
6. Leukemia Drug Turns Mini-Molecules Up, Cancer Genes Down
7. Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane
8. Scientists Discover Hormone That Controls Hunger
9. Brain behind the Brawn: Vital Molecule in the Brain Controls Appetite
10. Stronger Quadricep Controls Knee Osteoarthritis
11. Molecular ‘On/Off Switch’ Controls Immune Defenses Against Viruss
Post Your Comments:
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... chronic illnesses can receive effective, less expensive care from a ... to a team of dedicated health care professionals, a new ... ill and need either hospitalization or a trip to the ... home clinic at the University of Texas in Houston versus ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... closing in on a "fountain of youth" drug that can ... older adults, a new study suggests. Seniors received a ... that targets a genetic signaling pathway linked to aging and ... The experimental medication, a version of the drug ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Plugin creators ... ProFire 5k. A fully customizable business presentation tool made ... “Adding the ProFire 5k business tool, users can now ... Austin, CEO of Pixel Film Studios. “ProFire 5k gives ... style to add professionalism to a presentation” , Pixel ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those in the ... holiday season, AlignLife looks forward to their annual toy drive. ... Mahalko-Leonhardt, owner of AlignLife. "It brings our patients as well ... able to give kids toys for Christmas who would be ... of our patients." , The 70 toys were donated to ...
(Date:12/24/2014)... Recently, iFitDress.com, a famous dress manufacturer and retailer, ... $150 . All these items are brand new; they are ... been updated with the new range of high quality prom ... All iFitDress.com’s designs are made according to the latest trends. ... Every outfit from the company is handpicked by skilled tailors. ...
Breaking Medicine News(10 mins):Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2
... the artery-opening devices , , FRIDAY, May 9 (HealthDay News) ... tiny tools that have extended the lives of millions ... their arteries. , The wire metal mesh tubes, when ... artery and ensure a constant supply of blood to ...
... Week with Signing Bonuses, Raises, SAGINAW, Mich., May ... Saginaw voted overwhelmingly last,night to accept their first labor ... year wage increases of 4 percent., (Logo: ... Week I have had in years. The money is,important, ...
... May 9 Brookdale Senior,Living Inc. (NYSE: BKD ... the Company at the Bank of America 2008 Health ... Mandalay Bay in Las Vegas,Nevada at 4:40 p.m. PDT ... being webcast live and can be accessed through the,Bank ...
... May 9 Tim Booth, a 20-year health,care ... CEO of PrePak Systems,Inc., a turnkey pharmaceutical packaging ... last week by the company,s parent, PrePak,Holdings, which ... and,expansion with financial support from its largest shareholders, ...
... May 9 Almost Family, Inc.,(Nasdaq: AFAM ... nursing,services, today announced that the underwriter of the ... and purchased 262,500,additional shares of common stock at ... the over-allotment, the Company sold 2,512,500 shares,in the ...
... painful periods, glaucoma, depression and many other diseases, ... -- A new class of drugs called vaptans ... of conditions including painful periods, brain hemorrhage, psychotic ... short for vasopressin-receptor antagonists, work by targeting the ...
Cached Medicine News:Health News:Drug-Coated Stents Still Spark Debate 2Health News:Drug-Coated Stents Still Spark Debate 3Health News:Saginaw Nurses Approve First Contract 2Health News:Booth Joins PrePak Systems for Growth, Expansion 2Health News:Almost Family, Inc. Announces Exercise of Over-Allotment Option 2Health News:New Class of Drugs Might Treat Many Conditions 2
(Date:12/24/2014)... -- In response to urgent requests from the Deputy Minister of ... , Direct Relief delivered two 10-bed medical tents to ... local health workers who contract Ebola while fighting the outbreak. ... was constructed for foreign health care workers who may contract ... Sierra Leonean health workers. With Sierra ...
(Date:12/22/2014)... , Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), ... CytoSorb® blood purification technology to help fight deadly ... 28 countries worldwide, today announced the appointment of ... FACS, as its Senior Vice President of Clinical ... Dr. Di Russo is an accomplished ...
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has announced ... Market" report to their offering. ... focuses on the developments in the self-monitoring blood glucose ... Reimbursement analysis and the effects of competitive bidding have ... SMBG meters have been performed, based on the various ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5US Self-monitoring Blood Glucose Market 2
... WASHINGTON , July 28 Today FRC Action joined 19 pro-life groups ... requesting that Ella, a drug under consideration for FDA approval that can cause abortions but ... , , ... Vice President , made the following comments: , ...
... July 28 Delcath Systems, Inc. (Nasdaq: DCTH ) announced today ... Management Access Conference in New York, NY on Tuesday, August ... Chief Financial Officer, will review the company,s business strategy and recent corporate developments. ... Attendance at this conference is ...
Cached Medicine Technology:FRC Action and Pro-Life Coalition Urge the FDA to Reject New Abortion-Causing Drug 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: