Navigation Links
Painkillers Linked to Still More Problems

Two recent studies have offered still more evidence of the dangers linked with certain painkillers including kidney problems// in addition to the heart concerns that was already raised with the drug marketed as Vioxx.

One report from Brigham and Women's Hospital, and Harvard Medical School, Boston, said that an analysis of 114 studies that involved over 116,000 people showed that rofecoxib commonly known as Vioxx "was associated with increased renal and (heart) arrhythmia risks."

The reason as to why the drug would cause kidney damage is still unclear. In September 2004 Merck & Co Inc. withdrew Vioxx from the market after a three-year study revealed that it doubled the risk of heart attack and strokes in patients taking it for at least 18 months.

Another report from the University of Newcastle, New South Wales, Australia, following a review of 23 studies confirms the findings of an increased risk of heart problems with Vioxx that could be found "during the first 30 days of treatment in contrast to the the original suggestion that the vascular risk was only seen after 18 months."

Merck, however, facing more than 11,500 product liability lawsuits from people with claims of problems from Vioxx, has said that it still believes the data confirm the increased heart risk begins only after the medicine had been taken for 18 months.

The Australian analysis also found that celecoxib commonly sold as Celebrex and marketed by Pfizer Inc. was not associated with heart problems at a dose no greater than 200 milligrams a day.

Its review has also raised serious questions about the safety of diclofenac, an older (analgesic) drug marketed more in Europe than the United States.

The report added, "In conclusion ... diclofenac seems to share this risk and, unlike celecoxib, it appears to be harmful at commonly used doses. We believe there are grounds for reviewing its regulatory status."

The research details hav e been published in this week's Journal of the American Medical Association.

David Graham, a physician who works for the U.S. Food and Drug Administration said, "What does this all mean? First, rofecoxib (Vioxx) increases the risk of acute myocardial infarction at low and high doses." There is no initial 18-month period of immunity from risk."

He added that Celebrex "also increases (heart) risk at doses higher than 200 mg/d ... several other NSAIDs (non-steroidal anti-inflammatory drugs) increase risk, including ... diclofenac and meloxicam ... indomethacin and probably ibuprofen," while studies agree that naproxen is "neutral" for heart attack risk.

Graham added that for most patients with arthritis or other conditions requiring chronic pain relief "naproxen appears to be the safest NSAID choice from a cardiovascular perspective." Naproxen is commonly known as Aleve and marketed by Bayer Corp.
NLA
'"/>




Related medicine news :

1. Painkillers Do Not Shorten Dying Patients Lives
2. Painkillers may protect against Alzheimers disease
3. Painkillers may raise miscarriage risk
4. Painkillers Increase Risk of Miscarriage
5. In The Habit Of Taking Painkillers For Your Chronic Headache? Time To Switch Over
6. Aspirin Might Counter Side Effects of Cox-2 Painkillers
7. Painkillers Lead To Liver Failure
8. Study Advocates Use Of Oral Painkillers After Cesarean Section
9. Overdose of Opioid Painkillers Can Kill Pain and The Patient
10. UK Recommendations On Painkillers Flaunted
11. Painkillers—New and Old—Increase the Risk for Heart Attak
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2018)... ... December 07, 2018 , ... “The Better ... in world affairs, U.S. leadership and funding at the United Nations matters. We ... in reducing extreme poverty and advancing global health plus meaningful reforms in development, ...
(Date:12/6/2018)... ... 06, 2018 , ... We all know stress is unavoidable, ... M.D.-formulated Relaxium Calm is a dietary supplement developed to promote relaxation and elevate ... of the ashwagandha root. Ashwagandha is a powerful herb that has been utilized ...
(Date:12/5/2018)... ... 05, 2018 , ... Body by Ravi Plastic Surgery and ... Houston to offer the BodyTitePRO treatment. Dr. Ravi Somayazula , practice founder, ... and noninvasive techniques to improve the face, breast and body. Together with his ...
(Date:12/5/2018)... ... December 05, 2018 , ... Advanced ... Consulting services, announced its new office location in Paris, France during the Partnerships ... clinical trial operations in Europe and additional in-country personnel. , “The new office ...
(Date:12/5/2018)... ... December 05, 2018 , ... Domenic ... In this role, he will be responsible for the executive oversight of operations ... conducted an extensive, nationwide search for this position,” Tom Doran, president, HM Insurance ...
Breaking Medicine News(10 mins):
(Date:12/5/2018)... ... 2018 , ... Florida Hospital West Florida Division has once ... prestigious Leapfrog Group, a national nonprofit health care ratings organization, announced the Top ... Sebring, Florida Hospital Wesley Chapel and Florida Hospital Zephyrhills all received the Top ...
(Date:12/5/2018)... ... December 05, 2018 , ... ... caregivers to achieve better health outcomes, today announced the launch of its new ... subsidiary of Pillsy and will leverage its pioneering technology to enhance users’ control ...
(Date:11/29/2018)... ... November 29, 2018 , ... ... product makes the company’s powerful electronic forms and eSignatures functionality accessible via tablets, ... leaps and bounds in the consumer space and it’s about time hospital solutions ...
Breaking Medicine Technology: