Navigation Links
Painkillers Linked to Still More Problems

Two recent studies have offered still more evidence of the dangers linked with certain painkillers including kidney problems// in addition to the heart concerns that was already raised with the drug marketed as Vioxx.

One report from Brigham and Women's Hospital, and Harvard Medical School, Boston, said that an analysis of 114 studies that involved over 116,000 people showed that rofecoxib commonly known as Vioxx "was associated with increased renal and (heart) arrhythmia risks."

The reason as to why the drug would cause kidney damage is still unclear. In September 2004 Merck & Co Inc. withdrew Vioxx from the market after a three-year study revealed that it doubled the risk of heart attack and strokes in patients taking it for at least 18 months.

Another report from the University of Newcastle, New South Wales, Australia, following a review of 23 studies confirms the findings of an increased risk of heart problems with Vioxx that could be found "during the first 30 days of treatment in contrast to the the original suggestion that the vascular risk was only seen after 18 months."

Merck, however, facing more than 11,500 product liability lawsuits from people with claims of problems from Vioxx, has said that it still believes the data confirm the increased heart risk begins only after the medicine had been taken for 18 months.

The Australian analysis also found that celecoxib commonly sold as Celebrex and marketed by Pfizer Inc. was not associated with heart problems at a dose no greater than 200 milligrams a day.

Its review has also raised serious questions about the safety of diclofenac, an older (analgesic) drug marketed more in Europe than the United States.

The report added, "In conclusion ... diclofenac seems to share this risk and, unlike celecoxib, it appears to be harmful at commonly used doses. We believe there are grounds for reviewing its regulatory status."

The research details hav e been published in this week's Journal of the American Medical Association.

David Graham, a physician who works for the U.S. Food and Drug Administration said, "What does this all mean? First, rofecoxib (Vioxx) increases the risk of acute myocardial infarction at low and high doses." There is no initial 18-month period of immunity from risk."

He added that Celebrex "also increases (heart) risk at doses higher than 200 mg/d ... several other NSAIDs (non-steroidal anti-inflammatory drugs) increase risk, including ... diclofenac and meloxicam ... indomethacin and probably ibuprofen," while studies agree that naproxen is "neutral" for heart attack risk.

Graham added that for most patients with arthritis or other conditions requiring chronic pain relief "naproxen appears to be the safest NSAID choice from a cardiovascular perspective." Naproxen is commonly known as Aleve and marketed by Bayer Corp.
NLA
'"/>




Related medicine news :

1. Painkillers Do Not Shorten Dying Patients Lives
2. Painkillers may protect against Alzheimers disease
3. Painkillers may raise miscarriage risk
4. Painkillers Increase Risk of Miscarriage
5. In The Habit Of Taking Painkillers For Your Chronic Headache? Time To Switch Over
6. Aspirin Might Counter Side Effects of Cox-2 Painkillers
7. Painkillers Lead To Liver Failure
8. Study Advocates Use Of Oral Painkillers After Cesarean Section
9. Overdose of Opioid Painkillers Can Kill Pain and The Patient
10. UK Recommendations On Painkillers Flaunted
11. Painkillers—New and Old—Increase the Risk for Heart Attak
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2017)... South Carolina (PRWEB) , ... February 19, 2017 , ... ... of evening undergraduate nursing students, is being led by Amelia Joseph, Ph.D. Joseph was ... the initial operations of the nursing department in early 2016. After a nation-wide search, ...
(Date:2/18/2017)... , ... February 17, 2017 ... ... for Devicemakers , Sponsored by Axendia, **FDAnews Free Webinar**, March 1, 2017 ... manufacturers looking to reduce their regulatory burden? Pay dividends in enhanced and ...
(Date:2/18/2017)... (PRWEB) , ... February 18, 2017 , ... ... presets. Use Pixel Film Studios ’ ProParagraph Fashion Volume 2 for ... so many other applications. Users can pick and choose from hand-crafted trend-setting ...
(Date:2/17/2017)... FL (PRWEB) , ... February 17, 2017 , ... ... software tools that allow for the electronic prescribing of controlled and non-controlled substances ... , Ninety percent of pharmacies in the United States now accept electronic prescriptions, ...
(Date:2/17/2017)... WA (PRWEB) , ... February 17, 2017 , ... ... management organizations, has been named a finalist in the 8th Annual DecisionHealth Platinum ... America's healthcare delivery system. Qualis Health’s work is recognized across multiple award categories, ...
Breaking Medicine News(10 mins):
(Date:2/18/2017)... 17, 2017   Parker Waichman LLP, ... rights of victims injured by medical devices, comments ... call for better reporting. Congress required hospitals to ... concerns involving power morcellators and duodenoscopes prompted the ... how hospitals report injuries and deaths related to ...
(Date:2/18/2017)... , Feb. 17, 2017  Pharmaceutical companies have long ... products either in development or already on the market.   ... the pharma industry to alter how it manages advisory board ... leader Best Practices, LLC conducted a new study focused on ... ...
(Date:2/17/2017)... 2017  Ethicon, Inc. today announced a definitive ... held medical device company that manufactures and markets ... novel minimally invasive device for the surgical treatment ... enable Ethicon to offer patients a safe and ... surgical procedure. 1 This LINX ...
Breaking Medicine Technology: