Navigation Links
Pain-killer Drug Can Help Fight Breast Cancer

A new study using tissue cultures suggests, that a pain killing medication helps by halting the production of an enzyme that is key to a common form of breast cancer. The name of the painkiller is Nimesulide. //

In the labs experiments on breast cancer cells, scientists found that derivatives of nimesulide stopped the production of aromatase, the enzyme implicated in estrogen-dependent breast cancer. This form of cancer is the most common breast cancer in postmenopausal women. Aromatase converts hormones called androgens into estrogens, Estrogen is a powerful mitogen, which is an agent that causes cells to divide, and too much estrogen can cause cells to divide too quickly.

Robert Brueggemeier, professor of medicinal chemistry and pharmacognosy and dean of the College of Pharmacy at Ohio State University, and the co-author of the study states that many women with estrogen-dependent breast cancer take aromatase inhibitors to control their disease, the problem is that the current inhibitor drugs halt estrogen production throughout the body. Meaning that other parts like bones and brains, which need normal aromatase production, might suffer.

The results suggest that nimesulide may block aromatase production only in breast tissue. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID), used for pain and inflammation. Studies of other NSAIDs, such as ibuprofen, have suggested that NSAIDs may reduce breast cancer incidence by 40 percent. They said that by altering certain basic chemical structure of the drug, they could create several variations or analogs, of nimesulide. Nimesulide was banned from clinical and over the counter use in the United States due to rare cases of liver damage and related deaths.

The researchers took several of these analogs and in laboratory cultures, tested their effects on estrogen-dependent breast cancer cells taken from human breast tissue. They also tested them on human placental cells to see if the analogs would stop aromatase production in these cells. They found that the analogs stopped aromatase production in the breast cells, but not in the placental cells.

Brueggemeierm, stated that aromatase is important for normal functions of many tissues in the body, they still had to test it on other tissues. He further stated that the next step would be to see and study how the analogs affect other types of tissues to make sure that nimesulides aromatase-inhibiting effects are truly isolated to breast tissue. And then to learn how effective these compounds are when they are actually inside the body and what the potential side effects may be.


'"/>




Related medicine news :

1. Fight Heart disease and Pain with Meditation
2. Fight anemia by fortifying crops with iron!!!!!!!!
3. Fight arthritic pain with acupuncture
4. Smallpox Vaccine May Help Fight Cervical Cancer
5. Fight against E.coli
6. Red Wine Helps Fight Heart disease
7. Fish Oil Fights Arrhythmias, Sudden Death
8. SARS-Free Taiwan to Mark End Phase of Global Fight
9. Few Parents Help Kids Fight Acne
10. Common Cold Found to Fight Cancer
11. The Possibility Of Fighting HIV with Another Virus Questioned
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/9/2016)... NY (PRWEB) , ... December 09, 2016 , ... ... and Drug Dependence, Inc. (NCADD) is recommending the film Whispering Spirits ... and the District of Columbia as an education tool in the war against teen ...
(Date:12/9/2016)... ... December 09, 2016 , ... ... Pierre Hotel in New York, NY, on December 3rd, to benefit Holy Name ... attended the annual event, which raised over $1 million - the largest event ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... Quality Insights beginning January 1, 2017. The name change aligns the entire ... measuring and improving health care quality. , “We are very proud of the ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... pleased to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate ...
(Date:12/8/2016)... ... ... With the increasing demand for dental implants, the National Association of Dental ... dentists and patients about the safety issues related to dental restorations. According to the ... is projected to reach $6.4 billion in 2018 with more than 30 million Americans ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... DIEGO , Dec. 9, 2016 aTyr Pharma, Inc. ... discovery and development of Physiocrine-based therapeutics to address severe, rare diseases, ... at the upcoming BMO Prescriptions for Success Healthcare Conference at the ... on Wednesday, December 14, 2016, at 4:20 p.m. ET. ... ...
(Date:12/9/2016)... , Dec. 9, 2016  Axovant Sciences Ltd. ... biopharmaceutical company focused on the treatment of dementia, ... from a Phase 2b trial evaluating treatment with ... compared with donepezil plus placebo in people with ... addition of intepirdine to treatment was associated with ...
(Date:12/8/2016)... , Dec. 8, 2016 Australia Glaucoma ... GlobalData,s new report, "Australia Glaucoma Surgery Devices ... on the Australia Glaucoma Surgery Devices market. The ... volume (in units) and average prices (USD) within ... report also provides company shares and distribution shares ...
Breaking Medicine Technology: