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PSA Can Predicts The Treatment Response In Advanced Prostate Cancer

A new study that has been conducted by researchers from the University of Michigan (U-M) medical school states that patients with lower PSA levels, //7 months after therapy lived longer.

According to a new multicentre study that has been conducted by the Southwest Oncology Group and led by researchers at the U-M Comprehensive Cancer Centre, that has been published in the August 20th issue of the Journal of Clinical Oncology, has explained that a test that is usually done to detect prostate cancer could also help doctors to know when the treatment is working. They further mentioned that the level of the prostate specific antigen, or PSA, in man after seven months of hormone therapy for advanced prostate cancer might foretell how long he would survive.

The study evaluated 1,345 men with prostate cancer that had spread to distant parts of the body. The men were treated with seven months of androgen deprivation therapy, a treatment designed to block the effects of hormones on the cancer. PSA levels were monitored throughout the treatment. The researchers found that men whose PSA dropped below 4.0 ng/ml had a quarter the risk of dying compared to those whose PSA was more than 4.0.

“Our analysis showed that a low or undetectable PSA after seven months of androgen deprivation therapy is a powerful predictor of risk of death in patients with new metastatic prostate cancer. This could allow oncologists to identify patients who are unlikely to do well with this treatment long before they develop clinical signs of treatment resistance,” says lead study author Maha Hussain, M.D., professor of internal medicine at the U-M Medical School.

The researchers found 69 percent of the men maintained a PSA level of less than 4.0 ng/ml after seven months of treatment and 43 percent had an undetectable level of PSA at that time. Patients whose PSA was higher than 4.0 at the end of seven months survived 13 months, while patients whose PSA drop
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