Navigation Links
PSA Can Predicts The Treatment Response In Advanced Prostate Cancer

A new study that has been conducted by researchers from the University of Michigan (U-M) medical school states that patients with lower PSA levels, //7 months after therapy lived longer.

According to a new multicentre study that has been conducted by the Southwest Oncology Group and led by researchers at the U-M Comprehensive Cancer Centre, that has been published in the August 20th issue of the Journal of Clinical Oncology, has explained that a test that is usually done to detect prostate cancer could also help doctors to know when the treatment is working. They further mentioned that the level of the prostate specific antigen, or PSA, in man after seven months of hormone therapy for advanced prostate cancer might foretell how long he would survive.

The study evaluated 1,345 men with prostate cancer that had spread to distant parts of the body. The men were treated with seven months of androgen deprivation therapy, a treatment designed to block the effects of hormones on the cancer. PSA levels were monitored throughout the treatment. The researchers found that men whose PSA dropped below 4.0 ng/ml had a quarter the risk of dying compared to those whose PSA was more than 4.0.

“Our analysis showed that a low or undetectable PSA after seven months of androgen deprivation therapy is a powerful predictor of risk of death in patients with new metastatic prostate cancer. This could allow oncologists to identify patients who are unlikely to do well with this treatment long before they develop clinical signs of treatment resistance,” says lead study author Maha Hussain, M.D., professor of internal medicine at the U-M Medical School.

The researchers found 69 percent of the men maintained a PSA level of less than 4.0 ng/ml after seven months of treatment and 43 percent had an undetectable level of PSA at that time. Patients whose PSA was higher than 4.0 at the end of seven months survived 13 months, while patients whose PSA drop ped below 4.0 but above 0.2 lived 44 months and those whose PSA was undetectable, below 0.2 ng/ml, lived 75 months.

The men in the study were enrolled in a Phase III SWOG trial in which they would receive additional treatment after the seven months of initial hormone therapy. That study seeks to accrue 1,512 men. The patient's PSA level before beginning treatment must be at least 5.0 ng/ml to qualify for the study.

A PSA test measures the level in the blood of prostate specific antigen, an enzyme produced by the prostate gland. It is generally used as an initial screening test to detect prostate cancer.

“What is attractive about using PSA to predict survival in metastatic prostate cancer is that it is an easily measurable factor. These findings could help patients avoid ineffective treatment and could help researchers design further trials,” Hussain says.

Source: EurekAlrt.
'"/>




Related medicine news :

1. Restricted Activity Predicts Disability
2. Fitness Level Predicts Stroke
3. Being Teased Predicts Poor Psychological Functioning in Youth With Cleft Lip
4. Model Predicts Colon Cancer Inheritable Genetic Defects
5. Formula Predicts Osteoporotic Fracture Risk
6. Computer Tool Predicts Effectiveness Of Microbicides
7. New Genetic Test Predicts Eye-Cancer Patients Futures
8. Technology Predicts Outcome of Child Heart Surgery
9. A Secret Dossier Predicts Major Changes At NHS, England
10. Activation of a Particular Brain Region Predicts Altruism: Study
11. New Test Predicts CLL’s Sensitivity to Experimental Drug
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... ... March 23, 2017 , ... GeBBS Healthcare ... Assurance, at HCCA’s 21st annual Compliance Institute on March 26-28 in National Harbor, ... for all medical chart types with a comprehensive set of features including built-in ...
(Date:3/23/2017)... ... ... Woman Be Ye Healed-Passing On A Legacy”: a call to heal the wounded Church. ... author, Desiree M Webb, a registered nurse, minister of music, speaker, songwriter, recording artist, ... husband, Paul, for over twenty-nine years. Desiree enjoys writing, beach trips, ministering in ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... the existence of God. “A Respectful Response To Atheist Manifesto” is the creation ... married to his wife, Nancy, for sixty years. He holds graduate degrees from ...
(Date:3/23/2017)... ... March 23, 2017 , ... Vortex Biosciences, provider ... protein expression in circulating tumor cells using microfluidic western blotting” in Nature Communications ... Vortex technology to capture CTCs and a microfluidic single-CTC resolution Western ...
(Date:3/22/2017)... ... March 23, 2017 , ... Catalent Pharma Solutions, ... biologics and consumer health products, today announced that it had won the ‘Clinical ... at the Suntec Singapore International Exhibition & Convention Centre, Singapore. The award was ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 ... Piramal Enterprises Limited, gibt die Ernennung von ... PPS bietet seinen globalen Pharmazeutikkunden eine einmalige ... eine wichtige Rolle für das erfolgreiche Wachstum ... kaufmännischer Leiter wird Herr Needleman dafür verantwortlich ...
(Date:3/23/2017)... March 23, 2017 Pre-market today, Stock-Callers.com ... PLC (NYSE: AGN), Horizon Pharma PLC (NASDAQ: HZNP), and Evoke ... stocks are part of the Healthcare sector, which was slightly ... 2017, with the NYSE Health Care Index adding about 0.1% ... S&P 500 also were up nearly 0.1% as a group. ...
(Date:3/23/2017)... 23, 2017 AbbVie, a global biopharmaceutical company, ... Julianne Hough is helping to raise awareness ... Know about ME in EndoMEtriosis . "   The ... to learn about and understand endometriosis, a disease affecting ... to address their symptoms with a healthcare professional.  Despite ...
Breaking Medicine Technology: