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PET Imaging Identifies Aggressive Kidney Cancers That Require Surgery

br> According to the study, 15 out of 16 clear cell renal carcinomas were correctly identified using G250 PET, resulting in a sensitivity of 94 percent. All 9 patients with non-clear cell renal masses were negative on the PET scan – which is highly predictive of a less aggressive cancer – resulting in a specificity of 100 percent.

“Antibody PET could end up changing the standard of care for patients with kidney cancer,” said the study’s senior author, Paul Russo, MD, a urologic cancer surgeon at MSKCC. “The excellent sensitivity and specificity of this tool supports the utility of G250 PET imaging in the work-up and management strategies for clinically localized renal masses and as an alternative to biopsy for distinguishing renal lesions.”

In the study, 25 patients scheduled to have surgery to remove a renal mass received intravenous 124I-cG250. PET images obtained prior to surgery were graded as positive or negative for antibody uptake. A pathologist unaware of PET scan results then classified resected tumor specimens as clear cell renal carcinoma or otherwise.

All patients were monitored for toxicity and the antibody infusion was well tolerated with no side effects or other adverse events related to the agent.

According to the authors, G250 PET may ultimately be used not only to determine the aggressiveness and extent of a patient’s disease prior to any surgical intervention, but also to measure the therapeutic effects of a particular treatment, and predict the likelihood of recurrence.

“The promising results of this trial have stimulated interest in a larger, prospective multi-center trial to confirm our findings, and ultimately greatly improve the clinical management of patients with kidney tumors,” said Dr. Divgi.

There were an estimated 38,890 new cases of renal carcinoma in the United States in 2006, and an estimated 12,840 deaths due to the disease. The majority of cases of renal
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