Navigation Links
PAI-2 Plays a Pivotal Role in Eye Infections

According to researchers at the University of Pennsylvania and Temple University Plasminogen Activator Inhibitor Type 2 (PAI-2) plays an important role in diseases of the eye. This is a protein which is founding skin and the tissue covering the eyes.// The researchers, led by Mina Massaro-Giordano, M.D., of the University of Pennsylvania’s Scheie Eye Institute, and Marcella Macaluso, Ph.D., of the Sbarro Institute for Cancer Research at Temple University (http://www.shro.org), published their study.

‘Cytoplasmic and nuclear interaction between Rb family proteins and PAI-2: a physiological crosstalk in human corneal and conjunctival epithelial cells,’ in Cell Death and Differentiation (http://www.nature.com/cdd).They recently presented their findings at the annual meeting of the Association of Research in Vision and Ophthalmology (ARVO) in Florida, which was attended by over 10,000 researchers. PAI-2, in either extracellular or secreted form, is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation.

High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. In their study, the Penn and Temple researchers demonstrate for the first time an interaction between PAI-2 and the tumor suppressing gene Rb2/p130 in the nucleus of the epithelial cells in the cornea and conjunctiva. According to the researchers, this interaction with Rb2/p130 and chromatin modeling enzymes may affect how PAI-2 is expressed. ‘There is a different expression of the protein between the epithelium of the cornea and conjunctiva cells,’ says Massaro-Giordano, an assistant professor of ophthalmology, cataract and refractive surgery at Sche ie. ‘This may help us understand the molecular mechanisms that dictate the different expression profiles of PAI-2 in human corneal and conjunctival epithelial cells.’

Source: Eureklert
'"/>




Related medicine news :

1. Chennai Plays Hosts To The Diabetes World Congress
2. Chennai Plays Hosts To The Diabetes World Congress
3. Brain Plays Vital Role In Maintaining Bone Density
4. Leptin Hormone Plays Key Role In Losing Weight
5. Happiness Plays An Important Role In Success
6. Brain Plays Important Role In Diabetes Cure
7. Nervous System Plays Role In Stem Cell Regulation
8. Media Plays Crucial Role In Flu Vaccinations
9. Farming Plays A Crucial Role In Reducing Global Warming
10. Alcohol Consumption Pattern Plays A Vital Role in Alcohol Related Injury
11. Leptin Plays A Vital Role among Female Patients Suffering From Asthma
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/21/2017)... ... 21, 2017 , ... In the inaugural 30-minute podcast of ... of Education Gregory A. Smith examines student privacy issues with University of Colorado ... Commercialism, Privacy, and the Failure of Policymaking . , Join Smith and ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... voice for people who have kidney disease. The theme “Describe a positive decision ... stories. Entrants needed to meet only one qualification— to have been diagnosed ...
(Date:9/20/2017)... ... 2017 , ... Announced that Clear Global (a ... market) has entered into an agreement on September 1, 2017 with The Post ... the first private Dental School to launch an online, accredited Post Graduate Program ...
(Date:9/20/2017)... ... September 20, 2017 , ... The Honey ... With Vaginas.” The goal is to ignite conversation via social media and word-of-mouth ... The brand has declared September “Humans with Vaginas” month, releasing a video celebrating ...
(Date:9/20/2017)... ... September 20, 2017 , ... Recognising that in today’s busy ... Greeny delivers positive results in just three weeks. Setting the groundwork for a ... Fitting seamlessly into hectic work and family schedules, participants can lose up to ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 6, 2017  Medical professionals are expected ... while treating their patients. Medical simulations offer ... involving patients. Simulation provides a safe method ... out procedures, refine techniques and build confidence, ... new technology, such as augmented reality, will ...
(Date:9/5/2017)... another milestone in their continued growth and success of the company.  Xyntek has ... engagements regionally.  ... at 318 West Adams Street, Suite 1528, Chicago, IL ... Xyntek's recently opened Midwest office will support the ... In addition to Xyntek,s headquarters ...
(Date:9/1/2017)... -- Explorers Like Us ( https://explorerslikeus.com/ ) is embarking on "An ... deliver these experiences as part of Life Environments™, a new ... better. ... nothing beats a walk, jog or simply playing in a ... the next best thing when getting there isn’t possible. Life ...
Breaking Medicine Technology: