Navigation Links
PAI-2 Plays a Pivotal Role in Eye Infections

According to researchers at the University of Pennsylvania and Temple University Plasminogen Activator Inhibitor Type 2 (PAI-2) plays an important role in diseases of the eye. This is a protein which is founding skin and the tissue covering the eyes.// The researchers, led by Mina Massaro-Giordano, M.D., of the University of Pennsylvania’s Scheie Eye Institute, and Marcella Macaluso, Ph.D., of the Sbarro Institute for Cancer Research at Temple University (http://www.shro.org), published their study.

‘Cytoplasmic and nuclear interaction between Rb family proteins and PAI-2: a physiological crosstalk in human corneal and conjunctival epithelial cells,’ in Cell Death and Differentiation (http://www.nature.com/cdd).They recently presented their findings at the annual meeting of the Association of Research in Vision and Ophthalmology (ARVO) in Florida, which was attended by over 10,000 researchers. PAI-2, in either extracellular or secreted form, is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation.

High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. In their study, the Penn and Temple researchers demonstrate for the first time an interaction between PAI-2 and the tumor suppressing gene Rb2/p130 in the nucleus of the epithelial cells in the cornea and conjunctiva. According to the researchers, this interaction with Rb2/p130 and chromatin modeling enzymes may affect how PAI-2 is expressed. ‘There is a different expression of the protein between the epithelium of the cornea and conjunctiva cells,’ says Massaro-Giordano, an assistant professor of ophthalmology, cataract and refractive surgery at Sche ie. ‘This may help us understand the molecular mechanisms that dictate the different expression profiles of PAI-2 in human corneal and conjunctival epithelial cells.’

Source: Eureklert
'"/>




Related medicine news :

1. Chennai Plays Hosts To The Diabetes World Congress
2. Chennai Plays Hosts To The Diabetes World Congress
3. Brain Plays Vital Role In Maintaining Bone Density
4. Leptin Hormone Plays Key Role In Losing Weight
5. Happiness Plays An Important Role In Success
6. Brain Plays Important Role In Diabetes Cure
7. Nervous System Plays Role In Stem Cell Regulation
8. Media Plays Crucial Role In Flu Vaccinations
9. Farming Plays A Crucial Role In Reducing Global Warming
10. Alcohol Consumption Pattern Plays A Vital Role in Alcohol Related Injury
11. Leptin Plays A Vital Role among Female Patients Suffering From Asthma
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... California (PRWEB) , ... January 20, 2017 , ... "TransFlare ... to use inside of Final Cut Pro X," said Christina Austin - CEO of ... the RED Dragon. Utilizing the Dragon Sensor,TransFlare 4K Mystique lens flare and light leak ...
(Date:1/20/2017)... ... ... Chocolate Biscuit”: a biographical account following a man who went on to support his country ... Ivey, born in Lynn Haven, Florida and at the age of 5, his family moved ... he joined the Navy and got married right out of boot camp. , He ...
(Date:1/20/2017)... ... ... a beautiful and enchanting tale that teaches children the true meaning of Christmas. “Journey to ... City, and a devoted woman of faith. , “Becoming a parent changes you. In ... my mind for years, but actually doing it might have been a while in coming ...
(Date:1/19/2017)... ... , ... Today, the Centers for Medicare & Medicaid Services (CMS) announced over ... (APMs) in 2017. Clinicians who participate in APMs are paid for the quality of ... Administration’s effort to build a system that delivers better care and one in which ...
(Date:1/19/2017)... ... ... weather here, many people will have to clear snow with snow blowers or shovels from ... they can be dangerous when used incorrectly. That’s why Amica Insurance is sharing ... snow blowers:, , When removing wet snow or debris from the ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Jan. 19, 2017 Report Details ... Alzheimer,s ... Leading Companies – our new study reveals trends, R&D ... and events affecting the Alzheimer,s disease therapeutics and diagnostics ... these key questions: - How is the Alzheimer,s disease ...
(Date:1/19/2017)... Incretin Mimetics/GLP-1 Agonists, SNDRIs, Lipase Inhibitors, Serotonin Receptor Agonists, Sympathomimetic-GABA Receptor ... market is expected to grow at a CAGR of 27.1% ... 38.7% in the second half of the forecast period. The market ... to 2027. The market is estimated at $1,058 million in 2016, ... ...
(Date:1/19/2017)... LONDON , January 19, 2017 ... Grothey ; European Oncology & Haematology, 2016;12(Suppl 2):3-8; ... ... http://photos.prnewswire.com/prnh/20151014/276718LOGO) Published recently in ... the peer-reviewed journal from touchONCOLOGY, an article by ...
Breaking Medicine Technology: