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Oxygen-Induced Damage A Leading Cause For Parkinson’s Diseas



Right now, Bennett and his colleagues don’t know why complex I was damaged in the Parkinson’s patients. ‘It could be that something has gone terribly wrong with the mitrochondrial genome passed down by a person’s mother that codes for several proteins in complex I,’ Bennett said. ‘Something could be wrong in the coding for genes that help complex I assemble. Or there could be environmental toxins. Our research is a first real step in understanding at a detailed biochemical level what the challenge is.’

Bennett said he now plans to model the observation by extracting mitochondrial DNA from the cells of donated PD brains, put the DNA into a cell and express it to see if the phenomenon can be eproduced.


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