Navigation Links
Oxygen-Induced Damage A Leading Cause For Parkinson’s Diseas

Cellular damage induced by oxygen free radicals may be one important factor contributing to Parkinson’s disease, reports a new study. //This groundbreaking study conducted by neuroscientists at the University of Virginia Health System highlights that damage of complex I, a protein that plays a major role in the electron transport chain inside the mitochondria has been blamed for cellular damage in Parkinson’s disease.

Using the brain cells from deceased Parkinson’s patients who donated to the UVa brain bank, Dr. Jim Bennett, a UVa neurologist, and colleagues, isolated complex I from the mitochondria of ten Parkinson’s brains and compared them to the complex I proteins from twelve normal brains. They discovered that the complex I assembly in Parkinson’s had 50 percent more damage from oxygen. The complex I in Parkinson’s brains also had evidence of not being properly assembled and had reduced electron flow, Bennett said.

‘This part of the protein complex is being damaged by oxygen free radicals more in a brain with Parkinson’s than it is in someone of same age who does not have PD,’ Bennett said. His research is published in the May 10th edition of the Journal of Neuroscience.

Oxygen free radicals are oxygen molecules that carry an extra electron. They are destructive because, in excessive amounts, they chemically attack the components of the cell, including proteins, DNA and lipids in cell membranes. One of the major problems of normal aging is an increased level of these free radical damaged proteins, along with damaged DNA and lipids.

Bennett believes that Parkinson’s patients may benefit one day from drugs that can slow the damage from free radicals. ‘If we could soak up the free radicals in mitochondria, then complex I could repair itself,’ Bennett said. ‘If this damage is caught in people early on, we might interrupt the progression of Parkinson’s disease. Such treatment is hypothetical at this point, but it is rational.’

Right now, Bennett and his colleagues don’t know why complex I was damaged in the Parkinson’s patients. ‘It could be that something has gone terribly wrong with the mitrochondrial genome passed down by a person’s mother that codes for several proteins in complex I,’ Bennett said. ‘Something could be wrong in the coding for genes that help complex I assemble. Or there could be environmental toxins. Our research is a first real step in understanding at a detailed biochemical level what the challenge is.’

Bennett said he now plans to model the observation by extracting mitochondrial DNA from the cells of donated PD brains, put the DNA into a cell and express it to see if the phenomenon can be eproduced.


Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
3. Arthritis Drug May Cause Liver Damage
4. Damage to arteries from injury can be avoided with carbon monoxide
5. Epilepsy Drug Helps Diabetic Nerve Damage
6. Different Sun Rays, Different Damage
7. Drug That Is Found To Reduce Heart Damage from Chemo
8. Cooling Can Reduce The Risk Of Brain Damage In Oxygen Deprived Newborns
9. Damaged Heart Rejuvenated By Stem Cells
10. Traffic Smoke May Damage DNA
11. Detecting DNA Damage With In-Vivo Alkaline Comet Assay
Post Your Comments:

(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... comparison chart and ingredient list of its hemorrhoid ointment to its website. , ... pain relief for people suffering from hemorrhoids. Adding the comparison chart and ingredient ...
(Date:11/30/2015)... ... November 30, 2015 , ... Advocare Orthopedic ... orthopedic care. Led by John Vitolo, M.D., the center offers their patients ... team at Advocare Orthopedic & Sports Medicine is ready to help their patients ...
(Date:11/30/2015)... ... November 30, 2015 , ... Newly reviewed and approved ... grandfather graduated from Tufts School of Dental Medicine in 1935. His father graduated ... Isola family being in dentistry as well as their commitment and passion to the ...
(Date:11/30/2015)... ... November 30, 2015 , ... Two years ago, Debbie Gregory, ... the David Lynch Foundation, learning Transcendental Meditation (TM). After encouraging a number of ... walk so that she could talk the talk. , TM is becoming one of ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... magazine, quoted Michael Hansen, Ph.D., a senior scientist at Consumer Reports as supporting ... so for a child’s exposure limits. , The original Nov 2015 CR story ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015   Nuance Communications, Inc. ... National Decision Support Company (NDSC) today jointly announced ... collaboration capabilities that utilize the American College of Radiology,s ... provider organizations to comply with current and emerging ... --> By combining clinical decision support, ...
(Date:11/30/2015)... , Nov. 30, 2015  Novartis will demonstrate the ... 57 th American Society of Hematology (ASH) Annual ... myelomas as well as supportive care, including key findings ... personalized cell therapies. The ASH Annual Meeting will be ... . Novartis Oncology . "We will be ...
(Date:11/30/2015)... Israel , Nov. 30, 2015  OticPharma, Ltd., ... and developing innovative therapies for ear, nose, and throat ... A. Katkin as chairman of the company,s board ... executive officer for OticPharma, Ltd.  "Keith brings a wealth ... will be able to share this experience and provide ...
Breaking Medicine Technology: