Navigation Links
Oxygen-Induced Damage A Leading Cause For Parkinson’s Diseas

Cellular damage induced by oxygen free radicals may be one important factor contributing to Parkinson’s disease, reports a new study. //This groundbreaking study conducted by neuroscientists at the University of Virginia Health System highlights that damage of complex I, a protein that plays a major role in the electron transport chain inside the mitochondria has been blamed for cellular damage in Parkinson’s disease.

Using the brain cells from deceased Parkinson’s patients who donated to the UVa brain bank, Dr. Jim Bennett, a UVa neurologist, and colleagues, isolated complex I from the mitochondria of ten Parkinson’s brains and compared them to the complex I proteins from twelve normal brains. They discovered that the complex I assembly in Parkinson’s had 50 percent more damage from oxygen. The complex I in Parkinson’s brains also had evidence of not being properly assembled and had reduced electron flow, Bennett said.

‘This part of the protein complex is being damaged by oxygen free radicals more in a brain with Parkinson’s than it is in someone of same age who does not have PD,’ Bennett said. His research is published in the May 10th edition of the Journal of Neuroscience.

Oxygen free radicals are oxygen molecules that carry an extra electron. They are destructive because, in excessive amounts, they chemically attack the components of the cell, including proteins, DNA and lipids in cell membranes. One of the major problems of normal aging is an increased level of these free radical damaged proteins, along with damaged DNA and lipids.

Bennett believes that Parkinson’s patients may benefit one day from drugs that can slow the damage from free radicals. ‘If we could soak up the free radicals in mitochondria, then complex I could repair itself,’ Bennett said. ‘If this damage is caught in people early on, we might interrupt the progression of Parkinson’s disease. Such treatment is hypothetical at this point, but it is rational.’

Right now, Bennett and his colleagues don’t know why complex I was damaged in the Parkinson’s patients. ‘It could be that something has gone terribly wrong with the mitrochondrial genome passed down by a person’s mother that codes for several proteins in complex I,’ Bennett said. ‘Something could be wrong in the coding for genes that help complex I assemble. Or there could be environmental toxins. Our research is a first real step in understanding at a detailed biochemical level what the challenge is.’

Bennett said he now plans to model the observation by extracting mitochondrial DNA from the cells of donated PD brains, put the DNA into a cell and express it to see if the phenomenon can be eproduced.


'"/>




Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
3. Arthritis Drug May Cause Liver Damage
4. Damage to arteries from injury can be avoided with carbon monoxide
5. Epilepsy Drug Helps Diabetic Nerve Damage
6. Different Sun Rays, Different Damage
7. Drug That Is Found To Reduce Heart Damage from Chemo
8. Cooling Can Reduce The Risk Of Brain Damage In Oxygen Deprived Newborns
9. Damaged Heart Rejuvenated By Stem Cells
10. Traffic Smoke May Damage DNA
11. Detecting DNA Damage With In-Vivo Alkaline Comet Assay
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... ... actively engaged in health and wellness best practices in the past couple of ... trend. February is American Heart Month, which acts as an exceptional opportunity to ...
(Date:2/11/2016)... ... February 11, 2016 , ... Research led by Providence Health ... common cancer screenings, especially among women. Cancer screenings are often the best way ... The study,“What Does Medicaid Expansion Mean for Cancer Screening and Prevention: Results from ...
(Date:2/10/2016)... ... 2016 , ... President Obama’s budget proposal yesterday enables the ... services via telehealth, estimated to generate more than $160 million in savings over ... years. Although there is more to be done, this represents an important ...
(Date:2/10/2016)... ... February 10, 2016 , ... Sherly Sulaiman, certified clinical ... of therapeutic sessions to help Los Angeles-area actors cope with rejection, improve their ... series, known as “Mindfulness for Actors and Artists,” has been featured in ...
(Date:2/10/2016)... ... February 10, 2016 , ... LaserShip, a regional parcel carrier ... Food Bank of Eastern Michigan last Friday in order to aid in the Flint ... Midwest to include a facility located in Clio, only 15 miles away from Flint. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... DIEGO , Feb. 11, 2016 ... groundbreaking cell-isolation method that opens the door to ... until now have been impossible to isolate with ... to isolate specific tumor types in various stages ... genetic variants of these cells that are clinically ...
(Date:2/11/2016)... , Feb. 11, 2016  NanoViricides, Inc. (NYSE ... has entered into an agreement with the University ... drug candidates in standard animal models of ocular ... Research Director. Dr. Romanowski has extensive experience in ... --> Eric Romanowski , Research Director. ...
(Date:2/11/2016)... -- North America , Europe ... global market is expected to reach USD 20,190.1 Million by 2020 ... 10.2%. --> North America , ... The global market is expected to reach USD 20,190.1 Million by ... of 10.2%. --> According to a new market research ...
Breaking Medicine Technology: