Navigation Links
Osteoporosis – A New Treatmen

cineurin/NFATc activity experience bone loss, Winslow, Crabtree, and their colleagues wanted to see whether this pathway would be important in bone development and function as well. They studied mutant mice in which the NFATc1 in osteoblasts had been modified so that it could move more easily to the nucleus and become a little more active than usual.

Mice with the hyperactive NFATc in their osteoblasts had an immense increase in bone mass compared to normal mice, suggesting that the balance between bone formation and breakdown had tipped.

When the researchers examined the cells in these mice, they found that up-regulating NFATc signaling in osteoblasts increased the numbers of both types of bone cells. ‘It was clear that increased NFATc activity in osteoblasts influenced both osteoblasts and osteoclasts,’ Winslow said.

The researchers found that mice that showed enhanced NFATc activity in their osteoblasts had many more of these bone-forming cells, which explained the increase in bone mass. They also found a possible explanation for why there were more bone-destroying osteoclasts. Osteoblasts with hyperactive NFATc expressed higher levels of inflammatory proteins called chemokines, which promote osteoclast development.

‘Osteoblasts produce factors that recruit the progenitors of osteoclasts, and so when osteoblast numbers go up, osteoclast numbers go up,’ Crabtree said. This link between osteoblast and osteoclast numbers explains in part how the two types of cells normally stay balanced in animals, he added.

Mice with abnormally active NFATc probably develop so much bone mass because this delicate balance between osteoblasts and osteoclasts has been altered, Crabtree suggested. In the mutant mice, ‘there's also a huge increase in osteoclasts, but they never catch up,’ he said. ‘The balance has been tipped.’

This imbalance between bone formation and degradation could potentially be recreated by drug tre
'"/>




Page: 1 2 3

Related medicine news :

1. New treatment for Osteoporosis
2. Osteoporosis in men
3. Osteoporosis Drugs: right time to take-off
4. Fluoride Found Effective in Osteoporosis
5. Mutation connected to Osteoporosis
6. Osteoporosis associated with Childhood Cancer
7. A treatment for Osteoporosis
8. Osteoporosis could be caused by irregular periods
9. Back exercises reduces Osteoporosis
10. Osteoporosis and kidney stones gene marker identified
11. The Answer To Prevent Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Osteoporosis New Treatmen

(Date:7/22/2014)... 2014 Two individuals from Meditec, a ... Association for Healthcare Documentation Integrity (AHDI) Awards. One nominee ... the sole nominee for both the Excellence in Credentialing ... Linda Curia, is also nominated for the Rising Star ... field for over 18 years in a wide-variety of ...
(Date:7/22/2014)... NY (PRWEB) July 22, 2014 As ... Icahn School of Medicine at Mount Sinai have helped ... with the risk of developing schizophrenia, in the largest ... conducted with 80,000 people. The findings, published online in ... underlie schizophrenia, and could lead to new approaches to ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 University ... officially opened the doors of its state-of-the-art, $151 ... in the heart of downtown San Francisco's South of ... 10,000 patients a year. Those patients will now be ... sophisticated iKiosks . , Advanced Kiosks engineering ...
(Date:7/22/2014)... 22, 2014 (HealthDay News) -- Genetic fragments of the deadly ... where an infected camel was kept, a new study says. ... determine if Middle East Respiratory Syndrome (MERS) can be transmitted ... samples over three consecutive days from a camel barn owned ... the town of Jeddah, Saudi Arabia. The man later died. ...
(Date:7/22/2014)... electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS), ... Like antidepressant medications, however, they typically have a ... several weeks of regular ECT treatments before a ... an impetus to develop antidepressant treatments that act ... (LFMS) is one such potential new treatment with ...
Breaking Medicine News(10 mins):Health News:Meditec Instructor and Student Nominated in Prestigious Medical Transcription Profession Awards 2Health News:Meditec Instructor and Student Nominated in Prestigious Medical Transcription Profession Awards 3Health News:Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date 2Health News:Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date 3Health News:Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date 4Health News:iKiosks Are Gateway to Premier Dental Facility 2Health News:iKiosks Are Gateway to Premier Dental Facility 3Health News:MERS Virus Found in Air in Camel Barn 2Health News:Low strength brain stimulation may be effective for depression 2
... pleased to announce the appointment of Dr. Elisa J. Zinberg as ... effective immediately. , ... Rye, NY (PRWEB) September 23, ... Elisa J. Zinberg as Vice - President of Operations, and member ...
... The ALS Association,s comprehensive Assistive Technology Consultation Program. The program ... ALS, also known as Lou Gehrig,s Disease, and training on available ... at the Associaton,s Chapters and Certified Centers of Excellence. , ... ...
... Coinstar Centers(R) at retail locations,nationwide, WASHINGTON, Sept. 22 ... to those affected by the recent,hurricanes by donating their ... retail locations. Simply select the Red Cross Disaster Relief ... Cross to provide immediate,food, shelter, counseling and other assistance ...
... Reasons for slowed time to treatment remain unclear, experts say ... including those on Medicaid, are more likely to take much ... strikes compared to more affluent people, a new study finds. ... at a greater risk of missing a critical window for ...
... SACRAMENTO, Calif., Sept. 22 The California Office of,Traffic Safety ... riding in car safety seats. The 2008 rate of 94.4 ... a big jump of 6.7,percentage points over the 2007 rate ... time to kick off the national Child,Passenger Safety Week, September ...
... model, it appears that comparing the benefits and risks ... and their physicians choose appropriate screening strategies, according to ... Archives of Internal Medicine , one of the JAMA/Archives ... known as Pap smears, is credited with reducing the ...
Cached Medicine News:Health News:Curemark Appoints Dr. Elisa J. Zinberg as Vice President of Operations 2Health News:DynaVox Sponsors The ALS Association's Assistive Technology Consultation Program 2Health News:DynaVox Sponsors The ALS Association's Assistive Technology Consultation Program 3Health News:Americans Urged to Support American Red Cross Disaster Relief Efforts for Hurricanes of 2008 2Health News:Heart Attack Care Often Delayed for the Poor 2Health News:Heart Attack Care Often Delayed for the Poor 3Health News:Record Upsurge in State's Child Safety Seat Usage Marks Child Passenger Safety Week 2Health News:Model highlights benefits and risks of cervical cancer screening methods 2
(Date:7/22/2014)... -- The number of people overdosing from opioid prescription ... percent of the workforce has misused prescription painkillers, according ... making opioid use a serious threat to employee safety. ... correct dosage with a valid prescription, subtle impairment may ... Safety Council released a guide for employers, ...
(Date:7/22/2014)... July 22, 2014 BiologicTx ® today ... first 3-way Kidney Paired Donation transplant exchange utilizing BiologicTx,s ... on July 9 at the Miami Transplant Institute, located ... Kidney Paired Donation (KPD) ... compatible for kidney transplant with one another due to ...
(Date:7/22/2014)... -- Elekta (NSE:EKTAb) and Royal Philips (NYSE: ... Trust ( Manchester, UK ), a specialist ... to develop the clinical value of an integrated magnetic ... system would, in principle, improve the practice of radiotherapy ... "The Christie was an essential participant in the project ...
Breaking Medicine Technology:5 things employers should know about prescription painkiller use 25 things employers should know about prescription painkiller use 3BiologicTx Paired Donation Aids In Successful Kidney Transplants 2BiologicTx Paired Donation Aids In Successful Kidney Transplants 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 4
... Lilly and Company (NYSE: LLY ) announced ... Lilly to access innovation being developed outside the company,s ... independent venture capital firms participating in the Mirror Portfolio ... stage of their development. The first is a molecule ...
... 2011 Mylan Inc. (Nasdaq: MYL ) ... launched Voriconazole Tablets, 50 mg and 200 mg, under ... Inc. Mylan was the first company to have filed ... for Voriconazole Tablets and was awarded 180 days of ...
Cached Medicine Technology:Lilly Marks Major Milestone for Mirror Portfolio with Agreement by Independent Fund to License First Two Investigational Medicines 2Lilly Marks Major Milestone for Mirror Portfolio with Agreement by Independent Fund to License First Two Investigational Medicines 3Lilly Marks Major Milestone for Mirror Portfolio with Agreement by Independent Fund to License First Two Investigational Medicines 4
MicroAmp Full Plate Covers, which are manufactured from PCR-compatible rubber, are non-sterile, autoclavable and guaranteed reusable up to five times....
96-Well PCR Plate Sealing Mat...
Inquire...
Inquire...
Medicine Products: