Navigation Links
Osteoporosis – A New Treatmen

Increasing the activity of a protein called NFATc1 tends to cause massive bone accumulation that target the drugs used to treat osteoporosis //- HHMI investigator Gerald Crabtree and HHMI predoctoral fellow Monte Winslow reports.

In vertebrates, bone is constantly being formed and being broken down throughout life. Cells called osteoclasts continuously degrade bone, while cells called osteoblasts replenish it.

‘Ideally, they are perfectly balanced,’ said Crabtree, the senior author of the study. ‘Over the course of a lifetime, if everything goes well, we'll maintain almost exactly identical bone mass.’ However, if the balance is upset, and more bone is destroyed than formed, osteoporosis results, increasing the risk of fractures.

The new study arose from the researchers' curiosity about reports that patients who were treated with the drug cyclosporine – often given to suppress the immune system before organ transplants – tended to lose bone mass. Those patients were also at increased risk of bone fractures, said first author Winslow, who led the study as an HHMI predoctoral fellow in Crabtree's lab. Winslow is now working as a postdoctoral fellow in the lab of HHMI investigator Tyler Jacks at the Massachusetts Institute of Technology.

Cyclosporine inhibits a signaling protein complex known as calcineurin, which chemically modifies the NFATc family of proteins. This modification changes its shape. With its new shape, NFATc can move into the nucleus of the cell, where it can trigger the activation of many genes. Although initially shown to regulate immune cell function, NFATc also functions in other cells to regulate heart development, blood vessel formation, neural development and function, and muscle development. Its function seems to depend on the time and place of its activation, like a context-sensitive key on a computer. In bone, it is NFATc1 that seems particularly important.

Since people with suppressed cal
'"/>




Page: 1 2 3

Related medicine news :

1. New treatment for Osteoporosis
2. Osteoporosis in men
3. Osteoporosis Drugs: right time to take-off
4. Fluoride Found Effective in Osteoporosis
5. Mutation connected to Osteoporosis
6. Osteoporosis associated with Childhood Cancer
7. A treatment for Osteoporosis
8. Osteoporosis could be caused by irregular periods
9. Back exercises reduces Osteoporosis
10. Osteoporosis and kidney stones gene marker identified
11. The Answer To Prevent Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Osteoporosis New Treatmen

(Date:7/29/2014)... 30, 2014 VogueQueen.com, a well-known online ... the newest trends in garment fashion by providing graceful ... is selling an all-inclusive array of sexy dresses ... online, a lot of customers take price into consideration. ... That makes the purchase more affordable for all clients. ...
(Date:7/29/2014)... diet rich in soy may help feminine hearts, but ... in Menopause , the journal of The North ... the diet of women in Asia, produces the least ... to Asian migrants to North America, leads to just ... switching to soy from a Western diet after menopause ...
(Date:7/29/2014)... 29, 2014 Daily Gossip indicates in its ... was created for any sufferer who is looking for an ... author of the new program, Sarah Summer, says that her ... from yeast infection, too. Actually, this is the reason why ... problem. , The Natural Cure for Yeast Infection ...
(Date:7/29/2014)... Washington, New York (PRWEB) July 29, 2014 ... to protecting the rights of victims injured by defective ... lawsuit has been filed by plaintiffs in Canada who ... risk of cardiovascular events with the low testosterone ... filed on July 22, 2014 in the Ontario Superior ...
(Date:7/29/2014)... 29, 2014 Regardless of the good ... special someone to share those with. Love is about ... , Love is also about overcoming all the ... have that perfect relationship, women need to know how ... the Enchant Him program, please visit the official website ...
Breaking Medicine News(10 mins):Health News:VogueQueen.com Now Provides Graceful And Sexy Lingerie Collection For August 2Health News:Soy may help women's hearts if they start early 2Health News:Natural Cure for Yeast Infection Review Reveals Sarah Summer’s Healing Method 2Health News:Class Action Lawsuit in Canada Alleges Manufacturer of Delatestryl Testosterone Injection Failed to Warn of Cardiovascular Risks, Parker Waichman LLP Reports 2Health News:Class Action Lawsuit in Canada Alleges Manufacturer of Delatestryl Testosterone Injection Failed to Warn of Cardiovascular Risks, Parker Waichman LLP Reports 3Health News:How to Reach the Heart of the Perfect Guy with "Enchant Him Program" - a Report by Daily Gossip Magazine 2
... It,s Our Money and Our Lives-Time to Take Control of Our Health Care , ... , , ... ... CHICAGO , March 11 Patient care ...
... , March 11 As reported in today,s ... Americans with atrial fibrillation are now on notice that the over-zealous ... are not approved by the U.S. Food and Drug Administration (FDA) ... doctors, and hospitals, decisions about treatment for their patients, heart conditions. ...
... scientists at the University of Leicester have made a new ... cancer and other disease such as Lupus and rheumatoid arthritis. ... Nature Immunology . http://www.nature.com/ni/index.html The work has ... Unit at the University of Leicester. Dr Melania Capasso, ...
... While there are many benefits of losing weight, weight ... weight loss, bones are being remodeled - breaking down old ... As a result, bone density is reduced, causing increased fragility. ... weight-bearing exercise, in this case, fast walking or jogging, did ...
... ... giving relief to contractors and property owners under the new rules. The effectiveness ... costs in the highly competitive business of renovations and repair. , ... Denver, CO (PRWEB) March 11, 2010 ...
... ... that help consumers find low-cost prescription alternatives, has launched its new web site complete ... a clear roadmap to follow in working with their doctor to choose lower priced ... ...
Cached Medicine News:Health News:Patient Safety Week - March 7-12, 2010 2Health News:Patient Safety Week - March 7-12, 2010 3Health News:Whistleblower Alerts Americans to Dangers of Risky Unapproved Treatment for Atrial Fibrillation 2Health News:Whistleblower Alerts Americans to Dangers of Risky Unapproved Treatment for Atrial Fibrillation 3Health News:Whistleblower Alerts Americans to Dangers of Risky Unapproved Treatment for Atrial Fibrillation 4Health News:Whistleblower Alerts Americans to Dangers of Risky Unapproved Treatment for Atrial Fibrillation 5Health News:Whistleblower Alerts Americans to Dangers of Risky Unapproved Treatment for Atrial Fibrillation 6Health News:Weight-bearing exercise does not prevent increased bone turnover during weight loss 2Health News:EPA's New Lead-Based Paint (LBP) Renovation, Repair and Painting Rule (RRP) Causes Headaches for Contractors and Property Owners Alike 2Health News:EPA's New Lead-Based Paint (LBP) Renovation, Repair and Painting Rule (RRP) Causes Headaches for Contractors and Property Owners Alike 3Health News:Find Safe, Affordable Prescription Alternatives at SplitMed.com - New Site for Discount Prescription Drugs 2
(Date:7/29/2014)... SALT LAKE CITY , July 29, 2014 /PRNewswire/ ... at The Grand American Hotel in Salt ... keynote speakers representing some of most respected healthcare organizations ... Health Catalyst , is an industry conference devoted ... of healthcare analytics,  an essential element of both accountable ...
(Date:7/29/2014)...  Novation, a VHA and UHC company, today ... features that automate key health care supply chain ... Association.  The new and enhanced ... Value Analysis, Item Master and Formulary – are ... most critical challenges brought on by health care ...
(Date:7/29/2014)...   Abide Therapeutics announced today the ... board of directors. Thornberry was previously senior vice ... Merck & Co. Inc., where she led discovery, ... diabetes, osteoporosis, fertility and contraception. Thornberry, a distinguished ... resulted in the discovery of Januvia TM , ...
Breaking Medicine Technology:Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 2Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 3Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 4Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 5Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 2Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 3Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 4Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 5Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 2Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 3
... is accepting applications for the ... or pre-clinical research focused on human protein therapies in ... The application deadline is April 1, 2011. ... protein products manufacturers in the world, launched the Octapharma ...
... 14 /PRNewswire-Asia-FirstCall/ -- Dehaier Medical Systems Ltd. (Nasdaq: ... an emerging leader in the development, assembly, marketing ... products in China, today announced that on October ... at the China International Medical Equipment Fair ("CMEF") ...
Cached Medicine Technology:Octapharma Accepting Applications for Research Grants Focused on Human Protein Therapies 2Dehaier Medical Shows New Products at 2010 China International Medical Equipment Fair 2Dehaier Medical Shows New Products at 2010 China International Medical Equipment Fair 3
For the qualitative detection of human Chorionic Gonadotrophin (hCG) in urine or serum specimens...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: