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Oral use of ZYVOX (Linezolid) is better to Intravenous Vancomycin use for Skin Infections

, Transplant Infectious Diseases/Clinical Research at the Barnes-Jewish Hospital in St. Louis, Mo. and lead investigator. “Using an oral agent eliminates the risk of IV complications, such as line infections, as well as the cost of IV administration. This study offers further evidence of the cost savings of oral linezolid to the health care system.”

USE of ZYVOX:

ZYVOX was initially approved in the United States in April 2000 for the treatment of complicated skin and skin structure infections (cSSSIs) and nosocomial pneumonia, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). ZYVOX is also used for infections caused by other bacteria and fungi.

SIDE EFFECTS of ZYVOX:

ZYVOX formulations are contraindicated in patients with hypersensitivity. Myelosuppression which causes anemia, leucopenia, pancytopenia, and thrombocytopenia has been reported in patients receiving Linezolid. Treatment involving ZYVOX should be discontinued if patients develop or have worsening myelosuppression. Lactic acidosis has been reported with the use of ZYVOX.

Peripheral and optic neuropathy has been reported in patients treated with ZYVOX, primarily those patients treated for longer than the maximum recommended duration of 28 days. In cases of optic neuropathy that progressed to loss of vision, patients were treated for extended periods beyond the maximum recommended duration. Visual blurring has been reported in some patients treated with ZYVOX for less than 28 days. The most commonly reported adverse events in adults across clinical trials were nausea, headache, and diarrhea.

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