Navigation Links
Opioids And Abnormal Pain Perception

A growing number of animal and human studies show that under certain circumstances, opioids can elicit unexpected changes in pain sensitivity, resulting in hyperalgesia (abnormally intense pain in response to painful// stimulation) and allodynia (abnormally intense pain in response to non-painful stimulation).

Interestingly, previous studies have found evidence for hyperalgesia only subsequent to brief exposure to opioid treatment. No reports of hyperalgesia following the prolonged administration of opioids for the treatment of chronic or cancer pain have yet been published. However, using the cold pressor test (CPT), several studies have suggested that opioid addicts (OAs) may exhibit hyperalgesia as shown by their ability to maintain their hand in ice-cold water for a significantly shorter duration than were healthy controls.

Recent evidence reported on increased pain sensitivity in animals following parenteral opioid administration and in humans subsequent to intravenously of short-acting opioids and possibly in drug addicts.

A new study, to be published in Drug and Alcohol Dependence (available online 17 October 2005) was designed with the objectives to test if drug addicts, while actively consuming opioids, differ from normal subjects in their latency of pain onset, pain intensity, or time required for hand withdrawal in response to the CPT; and, if indeed so, to determine whether the discontinuation of opioid consumption will reset their altered pain responses.

For the study, 60 heroin or methadone OAs who attended a 4-week inpatient detoxification program were exposed to the cold pressor test (CPT) upon entrance to the program, at 7 and 28 days subsequent to the cessation of opioid consumption (verified by repeated urine toxicology tests). Latency of pain onset (s), pain intensity (0–100 VAS), and tolerance (time for hand withdrawal) in response to the CPT were measured. The main findings of this study were t hat in response to the CPT, OAs had a longer mean latency for pain and a lower mean pain intensity rating, in comparison with healthy controls, whereas their mean time for hand withdrawal (tolerance) was shorter than that of the controls. In addition, their altered pain perception did not reset 4 weeks subsequent to the cessation of opioid use. The present study provides further evidence that OAs exhibit short tolerance to the CPT, as manifested by their quicker hand withdrawal, which can be interpreted as hyperalgesia.
'"/>




Related medicine news :

1. Back pain treated with Opioids
2. Opioids Linked to Worse Outcomes After Back Injury
3. Prescription Opioids Abused More Than Heroin - A Report Says
4. Early Detection Of Facial Abnormalities in a Fetus
5. Abnormal Brain Structure One Of The Reasons For Depression in Adolescents
6. Antidepressants Could Lead To Abnormal Bleeding
7. Abnormal heart rate and depression may increase death risk
8. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
9. Neglect In Childhood Could Cause Abnormal Behaviour In Adults
10. Detecting Brain Abnormalities in Babies Using New Brain Scanners.
11. New Abnormal Karyotypes Discovered in China
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2016)... (PRWEB) , ... February 06, 2016 , ... Shark ... to announce the launch of a new DRTV campaign with Belly Bands. , Having ... tried everything from sprays to puppy pads and find nothing works, get Belly ...
(Date:2/5/2016)... ... 2016 , ... Love is in the air at King Kullen! The local ... packaging. This staple for Valentine’s Day is a must-have, and can be picked up ... not only are long-stem roses available, but also other flower bouquets, elegantly wrapped and ...
(Date:2/5/2016)... ... February 05, 2016 , ... Successful recruitment and ... clinical and scientific initiatives have all marked the last 12 months at Roswell ... CEO of the nation’s oldest cancer center, Candace S. Johnson, PhD, outlined the ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... addition of micro-needling services in their Napa Valley office. The technique utilizes the ... Surgery Associates, Dr. Canales and Dr. Furnas, are part of only a select ...
(Date:2/5/2016)... ... ... After years as an active staff surgeon and having served as the director ... transitioned to chief of the Division of Plastic Surgery at what is now known ... began a second three-year term in January of 2016. , The original selection was ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)...  ivWatch, a medical devices company, is one of five ... Governor Terry McAuliffe,s office. ivWatch will be receiving ... an event to be held at the Science Museum of ... and business that have made significant contributions to science. ... http://photos.prnewswire.com/prnh/20160205/330117LOGO ...
(Date:2/5/2016)... Ala. , Feb. 5, 2016  Patients in ... high intensity focused ultrasound (HIFU) therapy no longer have to ... to announce its partnership with Urology Centers of Alabama ... the newly FDA-cleared procedure for qualifying patients. ... their expertise in the treatment of prostate cancer using many ...
(Date:2/5/2016)... Feb. 5, 2016 ... of the "Global Musculoskeletal Partnering 2010-2016: ... profile to their offering. --> ... of the "Global Musculoskeletal Partnering 2010-2016: ... profile to their offering. --> ...
Breaking Medicine Technology: