Navigation Links
Opioids And Abnormal Pain Perception

A growing number of animal and human studies show that under certain circumstances, opioids can elicit unexpected changes in pain sensitivity, resulting in hyperalgesia (abnormally intense pain in response to painful// stimulation) and allodynia (abnormally intense pain in response to non-painful stimulation).

Interestingly, previous studies have found evidence for hyperalgesia only subsequent to brief exposure to opioid treatment. No reports of hyperalgesia following the prolonged administration of opioids for the treatment of chronic or cancer pain have yet been published. However, using the cold pressor test (CPT), several studies have suggested that opioid addicts (OAs) may exhibit hyperalgesia as shown by their ability to maintain their hand in ice-cold water for a significantly shorter duration than were healthy controls.

Recent evidence reported on increased pain sensitivity in animals following parenteral opioid administration and in humans subsequent to intravenously of short-acting opioids and possibly in drug addicts.

A new study, to be published in Drug and Alcohol Dependence (available online 17 October 2005) was designed with the objectives to test if drug addicts, while actively consuming opioids, differ from normal subjects in their latency of pain onset, pain intensity, or time required for hand withdrawal in response to the CPT; and, if indeed so, to determine whether the discontinuation of opioid consumption will reset their altered pain responses.

For the study, 60 heroin or methadone OAs who attended a 4-week inpatient detoxification program were exposed to the cold pressor test (CPT) upon entrance to the program, at 7 and 28 days subsequent to the cessation of opioid consumption (verified by repeated urine toxicology tests). Latency of pain onset (s), pain intensity (0–100 VAS), and tolerance (time for hand withdrawal) in response to the CPT were measured. The main findings of this study were t hat in response to the CPT, OAs had a longer mean latency for pain and a lower mean pain intensity rating, in comparison with healthy controls, whereas their mean time for hand withdrawal (tolerance) was shorter than that of the controls. In addition, their altered pain perception did not reset 4 weeks subsequent to the cessation of opioid use. The present study provides further evidence that OAs exhibit short tolerance to the CPT, as manifested by their quicker hand withdrawal, which can be interpreted as hyperalgesia.

Related medicine news :

1. Back pain treated with Opioids
2. Opioids Linked to Worse Outcomes After Back Injury
3. Prescription Opioids Abused More Than Heroin - A Report Says
4. Early Detection Of Facial Abnormalities in a Fetus
5. Abnormal Brain Structure One Of The Reasons For Depression in Adolescents
6. Antidepressants Could Lead To Abnormal Bleeding
7. Abnormal heart rate and depression may increase death risk
8. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
9. Neglect In Childhood Could Cause Abnormal Behaviour In Adults
10. Detecting Brain Abnormalities in Babies Using New Brain Scanners.
11. New Abnormal Karyotypes Discovered in China
Post Your Comments:

(Date:11/29/2015)... ... , ... Khanna Vision Institute based in Los Angeles, announced that Dr. Khanna ... Peer Certification by the Board is done so the public knows that the Doctor ... after the completion of three years of training or Residency in Ophthalmology. This is ...
(Date:11/29/2015)... Aliso Viejo, CA (PRWEB) , ... November 29, ... ... is an all new and unique analog distortion effect tool designed specially for ... to their footage, and create limiltess looks with the easy-to-use modification controls. Destoying ...
(Date:11/28/2015)... ... November 28, 2015 , ... ... services, has added Chris Hafey and Claude Hooton to its board of directors. ... of North America (RSNA) 2015 Annual Meeting and continues to strategically transform its ...
(Date:11/28/2015)... ... ... 30th at 6:00 a.m. EST until 11:59 p.m. EST, customers will be ... 20% off orders $80 or more to free gifts with purchases, there will be a ... competitive e-commerce website for skin care and cosmetic needs, customers will save on already discounted ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... According to ... the recent 2015 American Dental Association meeting in Washington D.C. revolved around the fact ... a patient’s overall health. The talk stressed the link between periodontal disease (more commonly ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Nov. 26, 2015 ... of the "2016 Global Tumor Marker ... Volume and Sales Segment Forecasts, Innovative Technologies, ... report to their offering. --> ... the "2016 Global Tumor Marker Testing ...
(Date:11/26/2015)... November 26, 2015 --> ... combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced ... approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... has found that immunotherapy can be efficiently combined with ...
(Date:11/26/2015)... 3D bioprinting market is expected to reach ... by Grand View Research Inc. Rising prevalence of chronic diseases ... is expected to boost the market growth, as 3D bioprinting ... --> 3D bioprinting market is expected to reach ... by Grand View Research Inc. Rising prevalence of chronic diseases ...
Breaking Medicine Technology: