One-time melanoma screening of adults age 50 or older appears to be as cost-effective as other nationally recommended cancer screening programs, according to an article in the January issue of Archives of Dermatology.//
Melanoma is the only cancer for which incidence and death rates continue to increase in the United States, while screening continues to be underused, according to background information in the article. Treating melanoma costs more than $740 million each year in the United States. Older patients and those who have immediate relatives with melanoma are at higher risk. Knowledge regarding risk factors and the availability of treatment has spurred greater interest in screening; however, the lack of a large randomized trial proving screening efficacy has been cited as an obstacle preventing its widespread implementation.
Elena Losina, Ph.D., Boston University School of Public Health, and colleagues constructed a mathematical model to simulate the melanoma events that occur in a population, including disease occurrence, progression, detection with and without a screening program, treatment and death. The authors projected the additional costs of screening and the additional survival attributable to earlier detection. They then assessed the cost in dollars for every extra year of life gained (the cost-effectiveness) from melanoma screening by a dermatologist.
'We considered the following four screening strategies: background screening only; that is, skin examination at a routine non-dermatologist physician visit, followed by referral to a dermatologist, on average, once every five years; and one-time, every two years and annual screening by a dermatologist, all beginning at age 50 years,' the authors write.
In the model analysis, the cost-effectiveness of screening was about $10,100 per quality-adjusted life year gained for one-time screening compared with current practice. In other words, for every $10,100 in
costs associated with one-time screening, one individual would have one additional year of life because of the screening. In addition, costs totaled $80,700 per quality-adjusted life year gained for screening every two years compared with one-time screening, and $586,800 per quality-adjusted life year gained for annual screening compared with screening every two years. Among siblings of patients with melanoma, one-time screening cost $4,000 per quality-adjusted life year gained compared with current practice, screening every two years cost an additional $35,500 per quality-adjusted life year gained, and annual screening cost an additional $257,800 per quality-adjusted life year gained.
Cost-effectiveness analyses are typically used when large randomized trials of screening procedures cannot be done for either logistical or ethical reasons, the authors write. "Using this method, interventions in the United States are generally considered cost-effective at less than $50,000 per quality-adjusted life year gained or less than $100,000 per quality-adjusted life year gained," they continue.
'This study suggests that one-time screening of the general U.S. population at age 50 years for malignant melanoma is very cost-effective and that screening every two years of siblings of patients with melanoma may also be cost-effective, depending on disease progression rates,' according to the authors. 'Either screening programs should be expanded or efforts to perform a definitive efficacy trial should be initiated.'
Source-EurekalertRelated medicine news :1
. UV Radiation induces Melanoma2
. Latest device for identifying Melanomas3
. Melanoma caused by low DNA repair capacity4
. Hope for First New Melanoma Treatment in Decades 5
. Turmeric Found To Slow Down Melanoma Growth 6
. Gene in Melanomas7
. Antigenics Pharmaceuticals plans for Phase III trial of its Melanoma vaccine8
. Skin Cancer History Puts Post-menopausal White Women At Risk For Melanoma9
. Experimental Therapy Effective Against Malignant Melanoma in Horses10
. New Technique Could Revolutionize Melanoma Diagnosis and Treatment11
. Twin Treatment Could Be Used Increase Survival Rates In Advanced Melanoma