Navigation Links
Once-daily Nevirapine Has More Side-effects Than Twice-daily Dose

Once-daily nevirapine (Viramune) is associated with a higher risk of rash, leading to treatment discontinuation or interruption//, than twice-daily dosing of the drug, according to Canadian research published in the January edition of HIV Medicine. The investigators also found that individuals who took nevirapine once daily were more likely to experience liver complications than patients who took the drug twice a day. For these reasons, the authors conclude that once-daily nevirapine cannot be recommended.

Once-daily dose of antiretroviral therapy is becoming increasingly available, and may be a way of improving patient adherence to treatment. Nevirapine has a long plasma half-life and high steady state plasma concentrations meaning that it may be a suitable candidate for once-daily use.

To determine how suitable the drug is for use on a once-daily basis, investigators from Ottawa conducted a literature review to establish the pharmacokinetics, efficacy and safety of once-daily nevirapine (400mg once a day) versus twice-daily (200mg twice a day) dose of the drug.

A Medline search was performed to identify published, peer-reviewed studies examining this question. Abstracts from major international HIV meetings were also reviewed.

The pharmacokinetic data suggested that once-daily nevirapine dosing resulted in lower minimum nevirapine plasma concentrations compared with twice-daily treatment. However these studies theoretically support once-daily dosing assuming that optimal adherence was maintained.

Several clinical trials have evaluated the safety and efficacy of nevirapine in a once-daily dosing regimen. The 2NN study is the largest and best known of these. The Canadian reviewers therefore focused on once-daily and twice-daily nevirapine recipients enrolled in the 2NN study.

The investigators found that the proportion of treatment failures by, or before, week 48 of the 2NN study were comp
'"/>




Page: 1 2 3

Related medicine news :

1. New Dietary Approach To Manage Kidney Stones
2. Approaching through Telemedicine benefits patients
3. Gel Offers A More Targeted Approach
4. New Cost Effective Approach To Promote Sun Protection
5. Treatment Of Brain Aneurysms By A New Non-Surgical Approach
6. A New Approach In Treatment Neurogenic Detrusor Overactivity In Children
7. A New Diagnostic Approach To Pediatric Interstitial Lung Disease
8. Lazy Eye Can Be Effectively Treated By New Approach
9. Novel Approach to Identify Protein Links with Genetic Disorder
10. NHS To Be Reformed By Using A Hybrid Approach
11. Two-In One Approach To Prevent Incontinence After Prolapse Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Once daily Nevirapine Has More Side effects Than Twice daily Dose

(Date:3/1/2015)... The number of transvaginal mesh lawsuits ( ... weeks in two New Jersey litigations where attorneys at ... announces. , A Case List updated on February ... proceeding established for products manufactured by Johnson & Johnson's ... when 90 fewer cases had been centralized. Additionally, 1,700 ...
(Date:3/1/2015)... “ The Barrel Mill ” was featured ... takes a look at the latest and coolest technology products ... NewsWatch and a technology expert, conducted the review and shared ... drinks. , According to Home Distillation of Alcohol, it's understood ... there’s a pretty cool product that’ll help anyone achieve a ...
(Date:2/28/2015)... The MCA Youth Empowerment Conference aims to bridge ... gears towards the goal for a better future for ... in smaller groups will be held after the conference ... Entrepreneurship, Healthcare, Social and Volunteerism, Women and Youth Empowerment, ... , Young adults aged between 18-30 years that ...
(Date:2/28/2015)... Portland, OR (PRWEB) February 28, 2015 ... Duncan Fletcher of Game Change ... and Shannon Leinert about the benefits of athlete development ... underscores some of the unique challenges that athletes face ... on-field and future success. , Fletcher became involved in ...
(Date:2/28/2015)... The Heart Fit Clinic started doing External Counterpulsation ... The Heart Fit Clinic is also selling the machines ... The goal is to scale the business to help ... buy External Counterpulsation machines can be difficult process. ... process and achieve the desired results. , The ...
Breaking Medicine News(10 mins):Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 2Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 3Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 4Health News:An Oak Infusion Spiral was Featured on NewsWatch Television on January 30, 2015 2Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 2Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 3Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 4Health News:SCI TV Covers Athlete Development with Duncan Fletcher 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 3Health News:Clinicians Can Now Purchase External Counterpulsation with Heart Fit Clinic 2
... sugars to proteins a process called glycosylation ... Palter, researcher of Temple University, believes she ... in humans. Currently, her lab is involved in ... that could eventually play important roles in producing ...
... may actually contribute to learning the supposed "tonal languages", such ... Edinburgh University, UK, have exposed the first obvious connection between ... tonal languages can fundamentally alter the meaning of words, which ... so tough to learn for speakers of non-tonal languages such ...
... Times recently examined how researchers in Tanzania are training ... The researchers' efforts "capitalize" on the rats' strong sense ... ,Bart Weetjens, a former industrial designer, developed the ... as land mines, after he visited minefields and saw ...
... The Mexico Supreme Court on Friday announced that it ... Right's Commission, to review the constitutionality of a ... an abortion during the first three months' gestation, the ... Party of the Democratic Revolution in March in the ...
... epidemic in Canada, researchers warn.,"People are starting to lose their ... Heather Ferguson, president of the Hearing Foundation of Canada in ... hearing loss becoming a public health crisis." ,Due ... of people with hearing loss is expected to grow faster ...
... depression is a risk factor for osteoporosis, reports the ... A recent study found that people ages 50 and ... inhibitors (SSRIs) had double the rate of fractures as ... depression itself as a source of endocrine changes that ...
Cached Medicine News:Health News:Nervous Systems of Insects may Offer Clues on Neurodegenerative Diseases 2Health News:Nervous Systems of Insects may Offer Clues on Neurodegenerative Diseases 3Health News:Genes may Have a Role in Learning "tonal Languages" 2Health News:Researchers Training Rats To Diagnose TB 2Health News:Mexico Supreme Court Accepts Petition To Review Mexico City Law Legalizing Abortion During First Three Months' Gestation 2Health News:Hearing Loss Becoming an Epidemic in Canada 2Health News:Hearing Loss Becoming an Epidemic in Canada 3
(Date:3/2/2015)... , Boston Scientific to acquire leading male urology ... $1.65 billion, with $1.6 billion in upfront cash ... Health business , Divestiture furthers Endo,s strategic ... Endo International plc (NASDAQ: ENDP ) (TSX: ... with Boston Scientific (NYSE: BSX ), under which ...
(Date:3/2/2015)... , March 2, 2015  BioMed Realty Trust, Inc. ... recaptured approximately 313,000 square feet of space in the ... in the world through the termination of Vertex Pharmaceuticals, ... effective February 28, 2015. BioMed Realty will ... will immediately begin to reposition the properties to meet ...
(Date:3/1/2015)... -- An innovative interventional radiology treatment has been found ... their headaches, according to research being presented at ... Annual Scientific Meeting . Clinicians at Albany Medical ... State College in Saratoga Springs used a treatment ... give patients enough ongoing relief that they required ...
Breaking Medicine Technology:Endo Announces Divestiture of American Medical Systems' Men's and Prostate Health Businesses to Boston Scientific 2Endo Announces Divestiture of American Medical Systems' Men's and Prostate Health Businesses to Boston Scientific 3BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 2BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 3Image-guided treatment shown to break the migraine cycle 2Image-guided treatment shown to break the migraine cycle 3Image-guided treatment shown to break the migraine cycle 4
... ConvaTec Healthcare, a world-leading developer, manufacturer and marketer ... today announced that in connection with a refinancing of ... facilities and in combination with new senior secured credit ... Notes and Senior Notes. The offering of the new ...
... -- China Medical Technologies, Inc. (the "Company") (Nasdaq: ... in-vitro diagnostic ("IVD") company, today announced that its ... ("GP Medical") and Beijing Yuande Bio-Medical Engineering Co., ... 415th, respectively, in the Deloitte Technology Fast 500 ...
Cached Medicine Technology:ConvaTec Healthcare Announces Senior Secured Notes Offering & Senior Notes Offering 2ConvaTec Healthcare Announces Senior Secured Notes Offering & Senior Notes Offering 3China Medical Technologies Announces its Subsidiaries, GP Medical and Beijing Yuande, Ranked 12th and 415th, respectively, in Deloitte Technology Fast 500 Asia Pacific 2010 Program 2
DMSO-resistant microplate sealing film...
Amplification Tape 96 featuring 3M adhesive technology. Good optical quality. Minimal autofluorescence. Certified RNase and DNase free....
Empore Sealing Tape Pads are ideal for covering a 96 well plate during storage or transfer to another work station. Not intended for use with auto-injectors....
... Microseal 'B' seals provide an adhesive-based ... microplates. The aggressive adhesive layer ensures secure ... cycling, and tight sealing during thermal cycling ... heated lid. The perforated end-tabs can be ...
Medicine Products: