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Omega-3 Again Linked to Lower Colorectal Cancer Risk

Increased intake of omega-3 fatty acids may cut the risk of colorectal cancer in men by a whopping 66 per cent, but only in men not taking// aspirin, suggests new research.

Omega-3 has been identified as one of the super-nutrients taking the food and supplements industry by storm. Much of its healthy reputation that is seeping into consumer consciousness is based largely on evidence that it can aid cognitive function and may help protect the heart against cardiovascular disease.

But one area in which the evidence is controversial is the fatty acid's role in reducing the risk of cancer. It has been proposed that omega-3 fatty acids may inhibit the omega-6 arachidonic acid (AA) cascade that has been linked to cancer formation and cell proliferation.

Metabolism of fatty acids produces compounds called prostaglandins, which can be either pro- or anti-inflammatory. The prostaglandins derived from omega-3 fatty acids are said to be anti-inflammatory and may protect against the development of cancer, while prostaglandins derived from omega-6 fatty acids, like AA, are proposed to be pro-inflammatory.

Writing in the journal Cancer Epidemiology Biomarkers & Prevention, lead author Megan Hall from Harvard School of Public Health states that aspirin has also been linked to a reduction in colorectal cancer via a similar mechanism.

The new research investigated the link between the fatty acid concentrations in the blood of 178 men with colorectal cancer (cases) and 282 healthy controls free from cancer. The controls were matched by age and smoking habits. Dietary assessment was obtained by using food frequency questionnaires.

After adjusting the results for potential confounding factors, Hall and her co-workers from Harvard Medical School and Brigham and Women's Hospital, report that amongst the entire population the highest versus lowest blood levels for total long-chain omega-3 fatty acids were associated
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