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Older Mothers Pass on Infertility Risk to their Daughters

he gives birth, the higher the chance her daughter will have impaired fertility.

Dr Nagy said, "A mother's reproductive age is important not only for herself, but it will determine to a certain extent the chances of her daughter or daughters being infertile. When we are treating patients close to the age of 40, we are helping them get babies but, at the same time, these children will have a higher risk of becoming infertility patients."

Fertility in women usually declines with age because damage accumulates in a woman's eggs and some of this genetic damage that builds up in older eggs is passed on to daughters, reducing the quality of their own eggs according to researchers.

Dr Nagy said, "In previous generations, parents were pretty young, but society is changing and a lot of women are delaying birth, so what we will see in 20 to 30 years' time will be very different. We might see a lot more infertility problems in the future."

Two years ago, it was found that the number of babies born to women aged 30 to 34 overtook the number born to women aged 25 to 29, according to the Office for National Statistics.

Bill Ledger, professor of reproductive medicine at Sheffield University, said: "This is fascinating. We know the best quality eggs are ovulated early in life, so there's been a lot of anxiety in the community about women waiting until they are close to menopause before ovulating the egg that becomes their son or daughter. What does that do to the child? They're saying that poor egg quality in mum links to poor egg quality in the daughter. The problem has been that until this generation, there haven't been enough children born to older mothers to study."

Another study reported at the meeting showed an increased risk of diabetes and heart disease in women who take the contraceptive pill for long periods in later life.
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