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Obesity is Related to Lower Tuberculosis Risk

According to a study in the Archives of Internal Medicine journal, Obese or overweight Chinese individuals age 65 and older have a lower risk of developing tuberculosis than those at a normal weight.

Tuberculosis is commonly associated with poverty and undernutrition in both developed and developing countries. In addition, obesity is an increasing problem that is associated with a wide range of chronic degenerative conditions, notably, diabetes mellitus, a well-reported predisposing factor for active tuberculosis, according to background information in the article.

Few studies have systematically examined the effect of obesity and overweight on tuberculosis, especially in Asian populations.

Chi C. Leung, M.B.B.S., Tuberculosis and Chest Service, Hong Kong, and colleagues, studied 42,116 individuals 65 years or older enrolled in 18 health centers for elderly patients in Hong Kong. The patients were followed up from three months after enrollment in 2000 until December 31, 2005.

The body mass index (BMI) of each patient was measured at the beginning of the study. Those with a BMI of less than 18.5 were grouped as underweight, 18.5 to less than 23 as normal, 23 to less than 25 as at risk (for obesity), 25 to less than 30 as overweight, and 30 or higher as obese.

During the follow-up period, 477 cases of active tuberculosis were reported, 326 (68.3 percent) of which were confirmed using cultures of the bacteria involved. The average time between enrollment and notification of tuberculosis was 881 days.

There were 395 new cases (82.8 percent) and 82 retreatment cases (17.2 percent). Pulmonary [lung] involvement was found in 426 cases (89.3 percent) and extrapulmonary [outside the lung] involvement in 87 (18.2 percent), including 36 cases (7.5 percent) with both, the authors write.

Individuals who developed active tuberculosis were taller on average, but had a lower body weight and BM
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