( People who are overweight or obese have...)Obesity could lead to Alzheimer's,Health

People who are overweight or obese have a greater risk of developing Alzheimer’s, the degenerative brain disease, a new study by US and Australian researchers // has claimed.

The research team - from Thomas Jefferson University in Philadelphia and the Edith Cowan University in Western Australia - say that being obese 'almost certainly' increases risk from Alzheimer's.

They have found a link between body mass index (BMI) and high levels of beta-amyloid, the sticky protein that builds up on the brain of Alzheimer's sufferers. The protein is thought to play a major part in the destruction of nerve cells in the brain and is linked to the behavioral and memory problems associated with the disease.

Alzheimer's is a form of dementia which affects the brain's memory function. It causes impaired memory followed by diminished thought and speech. The exact cause of the disease is not yet known.

Dr Sam E Gandy, co-author of the study, which appears in the Journal of Alzheimer's Disease, says they have found a relationship between obesity and circulating amyloid, and that is why the risk of Alzheimer’s is higher for obese people. In fact, heightened levels of amyloid in the blood vessels and the brain indicate the start of the Alzheimer's process.

Dr Gandy and his colleagues measured the body mass index and beta-amyloid levels in the blood. They also looked at several other factors associated with heart disease and diabetes, such as the inflammatory marker C-reactive protein, insulin, and high-density lipoprotein in 18 healthy adults who were either extremely overweight or obese. They found a statistically significant correlation between body mass index and beta-amyloid.

They also looked at several other factors associated with obesity including heart disease and diabetes in 18 healthy -but obese - adults. They found a 'statistically significant correlation' between BMI and beta-amyloid levels.

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