Navigation Links
Obesity Drug may Hold Potent Cancer Treatments

Boffins are designing potent cancer treatments using their knowledge about an obesity drug, orlistat (Xenical or Alli) that was found to kill cancer cells in the laboratory .

The drug binds and interacts with a protein found in tumour cells and blocks the protein's function and causes cell death.

The study was conducted by a team of researchers including Steven Kridel and W. Todd Lowther at Wake Forest University School of Medicine.

As part of the study, scientists analysed prostate cancer cells to see which enzymes were expressed at high levels to develop treatments to inhibit those enzymes to stop tumour growth.

Researchers found that a protein known as fatty acid synthase was expressed at high levels in prostate tumour cells, and was fairly absent in normal cells.

Earlier researches have shown that the protein was found in many tumour cells including breast, colon, ovarian, liver, lung and brain.

"High levels of fatty acid synthase correlate with a poor prognosis so it is a great treatment target. This makes an exciting treatment target because theoretically you don't have to worry about harming nearby healthy tissue," Kridel said.

Scientists used X-ray crystallography to get a three-dimensional snapshot of the drug interacting with the protein.

"Understanding this drug-protein interaction is essential for designing new drugs," Lowther said.

Researchers then screened hundreds of thousands of compounds to identify the ones that interacted with cancer cells in the same way as orlistat and narrowed the list of possibilities down to a dozen.

The researchers will now work to create potent cancer treatments by testing the drugs in animals and then in human cancer patients.

The findings of the study were published in Nature Structural and Molecular Biology.


'"/>




Page: 1

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Obesity raises IVF miscarriage risk
3. Obesity a risk for pancreatic cancer
4. Obesity shortens lifespan
5. Is Obesity a risk factor?
6. Obesity a global problem
7. Obesity increases health costs
8. Obesity in children a risk factor for diabetes
9. Decrease of Hunger Hormone after Obesity Surgery
10. Obesity risk for immobilized adults
11. Obesity risk can be reduced by eating breakfast regularly
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/18/2017)... ... August 18, 2017 , ... Radabaugh & Associates, a family ... in North-Central West Virginia, is embarking on a cooperative charity effort with the ... , The Chestnut Mountain Ranch (CMR) is a Christ-centered boarding school for young ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a Texas based insurance ... is spearheading a regional charity campaign organized to provide support to Christina Upchurch and ... this year, Christina and her children returned from out of town to find her ...
(Date:8/18/2017)... IN (PRWEB) , ... August 18, 2017 , ... Inc. ... annual list, the most prestigious ranking of the nation's fastest-growing private companies. This marks ... the exclusive Inc. 5000 ranking . This year’s ranking reflects ASH’s 76 percent ...
(Date:8/18/2017)... ... ... Our Imaginations: The Infinite God”: shows the importance of God in living a happy ... author, Mark Lawrence, born in Michigan, the author has lived in various communities and ... of God is that I have to be more mindful of feminine qualities to ...
(Date:8/18/2017)... ... ... the Snake”: an entertaining and moral-based short story about an unkind snake learning a ... Jr., a husband, father and grandfather who served as a U.S. Marine, U.S. Army ... for children and teens. My goal is to teach kids to use good judgement ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... Aug. 4, 2017 The search for test ... a physician/patient consult has long been the goal of ... notable focus of the largest meeting of lab professionals ... healthcare market research firm Kalorama Information.  The firm said ... offerings or related supplies and software were at the ...
(Date:8/2/2017)... BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital ... services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, ... that uses UVC light energy to kill deadly pathogens such as C. diff , ... Tru-D SmartUVC ... Tru-D in action in a patient ...
(Date:7/31/2017)... Mich. , July 31, 2017  Diplomat Pharmacy, Inc. ... in southeast Michigan by Crain,s ... ranks private and public companies by three-year revenue growth. This ... To view the complete list, visit ... Fast 50 is an incredible triumph," said Phil Hagerman ...
Breaking Medicine Technology: