Navigation Links
Obesity Drug may Hold Potent Cancer Treatments

Boffins are designing potent cancer treatments using their knowledge about an obesity drug, orlistat (Xenical or Alli) that was found to kill cancer cells in the laboratory .

The drug binds and interacts with a protein found in tumour cells and blocks the protein's function and causes cell death.

The study was conducted by a team of researchers including Steven Kridel and W. Todd Lowther at Wake Forest University School of Medicine.

As part of the study, scientists analysed prostate cancer cells to see which enzymes were expressed at high levels to develop treatments to inhibit those enzymes to stop tumour growth.

Researchers found that a protein known as fatty acid synthase was expressed at high levels in prostate tumour cells, and was fairly absent in normal cells.

Earlier researches have shown that the protein was found in many tumour cells including breast, colon, ovarian, liver, lung and brain.

"High levels of fatty acid synthase correlate with a poor prognosis so it is a great treatment target. This makes an exciting treatment target because theoretically you don't have to worry about harming nearby healthy tissue," Kridel said.

Scientists used X-ray crystallography to get a three-dimensional snapshot of the drug interacting with the protein.

"Understanding this drug-protein interaction is essential for designing new drugs," Lowther said.

Researchers then screened hundreds of thousands of compounds to identify the ones that interacted with cancer cells in the same way as orlistat and narrowed the list of possibilities down to a dozen.

The researchers will now work to create potent cancer treatments by testing the drugs in animals and then in human cancer patients.

The findings of the study were published in Nature Structural and Molecular Biology.


'"/>




Page: 1

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Obesity raises IVF miscarriage risk
3. Obesity a risk for pancreatic cancer
4. Obesity shortens lifespan
5. Is Obesity a risk factor?
6. Obesity a global problem
7. Obesity increases health costs
8. Obesity in children a risk factor for diabetes
9. Decrease of Hunger Hormone after Obesity Surgery
10. Obesity risk for immobilized adults
11. Obesity risk can be reduced by eating breakfast regularly
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/29/2016)... (PRWEB) , ... May 29, 2016 , ... Whole Health ... jaw clipper that has been available via Amazon.com. This new style of nail ... nails. , The jaw opening is approximately 4mm and the actual handle is 2.5mm ...
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In search of the K. ... theme event of “K Warriors” on June 4, 2016 at Ashbury Hotel and Suites ... is sponsored and hosted by Shaolin Institute and sanctioned by KSF (Kungfu Sanda Federation), ...
(Date:5/27/2016)... ... May 27, 2016 , ... Two director-level employees of ... Tribute to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen who ... this year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) Program ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities and thought leaders. ... from leading advocates, associations and industry leaders such as Bioness. , As ...
(Date:5/27/2016)... PALMYRA, Wis. (PRWEB) , ... May 27, 2016 ... ... over $90,000 in scholarships to students studying complementary medicine. Allison Outerbridge is this ... She accepted her award on May 18 at the university’s Student Leadership Awards ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... --   , ... Endpunkte und demonstriert Ebenbürtigkeit bei der Gesamtreinigung des ... guter , Reinigung des ... (Logo: http://photos.prnewswire.com/prnh/20130829/633895-a ) , ... der MORA-Studie der Phase III für NER1006 (1 ...
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
(Date:5/24/2016)... May 24, 2016  NxStage Medical, Inc. (Nasdaq: ... on advancing renal care, today announced that Jeffrey ... in the following schedule of investor conferences. Where applicable, ... at http://ir.nxstage.com/ .   ... Conference NY, NY           Friday, June 10, 2016 1:30 ...
Breaking Medicine Technology: