Navigation Links
Now, Silica Nanobubbles for Targeted Drug Delivery

Indian researchers at the Indian Institute of Technology (IIT), Chennai, have succeeded in entrapping antibiotics within silica nanobubbles and delivering them into cells, a// major step towards drug efficacy.

The researchers have used the 'Core-shell system' that comprises a core of one material and a shell of another (inert) material.

The possibility of delivering therapeutic molecules into cells and monitoring it through fluorescence imaging has opened up new possibilities, claims Thalappil Pradeep, who led the team at IIT.

They incorporated ciprofloxacin (a known antibiotic) molecules on the gold nanoparticle surface with subsequent growth of a silica shell over that. This was followed by removal of the gold core -- using a method they have patented -- leaving behind a "nanobubble" inside which the antibiotic was trapped.

"A hollow nanobubble or nanoshell of silica (10-20 nm in diameter, 1-2 nm shell thickness) contains about 65 molecules of ciprofloxacin," Pradeep told IANS. (Human hair by comparison is 100,000 nanometres thick).

He said that they used sophisticated techniques like "fluorescence anisotropy" to show that the molecules are confined within the cage.

The advantage of such nanoscopic containers is they provide a rigid environment for the trapped molecules protecting them from unwanted chemical reactions, said Pradeep.

Though core-shell systems are known, "what is new in our work is the entrapment of antibiotics within nanoceramic shells and their delivery into cells", he said. The drug-loaded nanobubbles are stable and can be stored for extended periods.

In actual experiments, Pradeep and his colleagues incubated the shells containing the antibiotic (or a fluorescence label) with E. coli bacteria and observed the distribution of the drug inside the bacterium by fluorescence imaging technique.

In this work, the shells were not made specific to the cells, Pradeep explained. But that is possible by attaching appropriate antibodies to the nanobubbles that would allow them to 'home in' on target cells.

The work of Pradeep and fellow researchers is to appear in the prestigious journal 'Langmuir'.

"As the porosity of the shells is controllable, controlled release of drugs can be achieved," they said. "Furthermore, stability, ease of synthesis and bio-compatibility of silica shells make this system a better choice in comparison to other chemical analogues."

Source-IANS
'"/>




Related medicine news :

1. Gel Offers A More Targeted Approach
2. New Vaccine Targeted At Effective Treatment Against Tuberculosis
3. Doctors, Pharma Companies Targeted By CBI Raids
4. Treatment Resistant Tumors Can Be Targeted Better Using Botox
5. KFC Targeted in Lawsuit
6. Targeted Anesthesia Can Minimize Pain During Prostate Biopsy
7. Targeted Compound Helps Recurrent Prostate Cancer Patients
8. Tumors Targeted Naturally
9. New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs
10. Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
11. Link between C-section Delivery and Stillbirth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... A local study examining asthma ... 40 percent of participating fifth-grade students already have or are at risk for ... Research in the Division of Pulmonary, Allergy and Critical Care Medicine at ...
(Date:5/5/2016)... ... May 05, 2016 , ... Sun Health registered ... the organization’s successful Care Transitions program at the 9th Annual Orthopedic ... “Minimizing Costs in the Post-Acute Environment Through Effective Transitions of Care.” , Major ...
(Date:5/5/2016)... ... May 05, 2016 , ... Talent Tech Labs (TTL) is pleased ... of National Nurses Week (May 6-12). Currently, HireNurses is a job listing ... into the Talent Tech Lab Virtual Incubation program, they will dramatically expand the functionality ...
(Date:5/5/2016)... ... , ... The Lung Institute will celebrate its three-year anniversary on May 14 by ... throughout the month of May. To date, the Lung Institute has treated over 2,000 people ... is a testament to the success of this treatment and to the patients who refuse ...
(Date:5/5/2016)... ... ... summer is just around the corner. Summer means a lot of different things to people. ... play all day and night. Parents often lament the coming of summer as they will ... means trips to the beach, backyard cookouts, fireworks on the Fourth of July, and even ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Diversified Holdings (NYSE: CODI ) ("CODI," "we," ... market businesses, announced today its consolidated operating results for ... First Quarter 2016 Highlights , Generated Cash Flow ... of $13.6 million for the first quarter of 2016; ... the first quarter of 2016; , Paid a ...
(Date:5/4/2016)... YORK , May 4, 2016 ... Share, Development, Growth and Demand Forecast to 2022 - Industry ... User (Hospital, Diagnostic Center and Others)" by P&S Market Research, ... $4,894.3 million in 2015, and it is expected to grow ... type, the high slice type segment is expected to witness ...
(Date:5/4/2016)... 4, 2016 Research ... "Global Multiple Myeloma Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Competitive Landscape Highlights 2016, provides comprehensive insights ... epidemiology, Multiple Myeloma market valuations and forecast, ...
Breaking Medicine Technology: