Navigation Links
Novel methods to view how a drug attaches to a cell

Researchers John Shelnutt and Yujiang Song from Sandia National Laboratories have discovered an innovative method to see how a drug attaches //to a cell which involves a new process that creates hollow platinum nanostructures. Sandia is a National Nuclear Security Administration laboratory.

An upcoming issue of the German chemical journal will publish the research as a paper in Angewandte Chemie Int. Ed which has currently published the same as an advance publication featured as a short article on its website. Shelnutt and Song in their paper explain a new way of producing porous, nanoscopic, hollow platinum spheres by using liposomes as blueprints. (Liposomes are microscopic, fluid-filled pouches that delivers vaccines, enzymes, or drugs to the body.) In earlier work, Shelnutt's group grew large continuous nanosheets of platinum on liposome templates, forming foam-like platinum nanostructures. This method provided no way to control shape and size.

The innovative method reported in the paper uses a different technique to produce porous platinum nanocages with diameters up to 200 nm. Instead of large sheets, they consist of many small flat-branched platinum structures - called dendrites - which join together in a network or cage in the shape of the spherical liposome.

The liposome that Shelnutt and his team used as a blueprint consists of a double layer of lipid (detergent) molecules. The liposomes are placed in a solution containing a platinum salt. When these liposomes are irradiated with light, photocatalysts located in the narrow space between the two layers of the lipid transfer electrons to the platinum ions. The uncharged platinum atoms gather into tiny metal clumps. Once they reach a certain size, they also become active and catalyze the dendrite growth by adding more platinum atoms from the platinum salt.

Little by little, small, flat, platinum dendrites form within the double lipid layer.

"The importan t thing is to make sure that the number of photocatalyst molecules - and thus the number of platinum clumps - within the liposome double layer is very high," Shelnutt says. "The resulting dendrites are then close enough to join and take the shape of the liposome. When the liposomes are broken up, the platinum spheres remain intact.

The thickness of the platinum shell around the sphere can be controlled by reducing or increasing the amount of the platinum salt placed into the solution. Shelnutt sees many potential applications for this process, including "nanotagging" biological structures such as drug molecules.

"This would involve labeling the drug by attaching a porphyrin molecule and, after allowing the drug to bind to a cell, using light to grow a nanometer-sized particle. The nanoparticles can then be imaged with electron microscopy to reveal the location of the drug receptor molecules on the cell," Shelnutt says. "This type of nanotagging technique might be used in non-biological applications as well - such as finding flaws in semiconductor surfaces."

Source-Eurekalert
MST
'"/>




Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/24/2017)... ... July 24, 2017 , ... A Southern California-based author has released a ... and how she has overcome them. “Forbidden Memories: A Memoir,” by author Michelle V. ... she has risen above. , In “Memories,” readers get a firsthand look at what ...
(Date:7/24/2017)... ... July 24, 2017 , ... Summer storms are inevitable as weather ... communities and often result in massive tree damage requiring emergency tree service. ... including tree trimming, tree cabling and hazardous tree removal. , “A summer ...
(Date:7/24/2017)... Province (PRWEB) , ... July 24, 2017 , ... ... Medicine's "Chinese Medicine Clinical Vitiligo Hospital" was set up, and the awarding ceremony ... of traditional Chinese medicine, the head of the army's health system, and national ...
(Date:7/24/2017)... ... ... “Nana Nana Boo Boo”: a delightful tale of a young girl who ... Boo” is the creation of published author Michael Rush, a Deputy Sheriff, former world ... Rush’s new book presents the importance of manners in a way easily understood by ...
(Date:7/24/2017)... ... , ... The Center for Addiction Recovery Training (CART), the ... second Multiple Pathways of Recovery Conference on October 23-26, 2017. This year, the ... foundational principle – a belief in multiple pathways of recovery, aims to bring ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides full-spectrum ... San Jose for hi-tech, pharmaceutical and biomedical devices ... its Fremont Innovation District, is excited to strategically partner with ... the hundreds of biotech, pharma and biomed companies throughout the ...
(Date:7/11/2017)... Research Corp., also known as ,The Epigenetics Company, announced today the release ... manner using the myDNAge ™ test. Based on Horvath,s Clock, so ... and biostatistics at the David Geffen School of Medicine at UCLA ... DNAge ™ technology is used to analyze DNA methylation patterns of ... ...
(Date:7/11/2017)... Fla. , July 11, 2017  Dr. Echenberg, founder of Echenberg ... therapy program to patients who suffer from painful intercourse and other painful ... and vaginal atrophy due to menopause. ... VuVatech LLC ... , created by Sarasota, Florida -based start-up company, VuVatech ...
Breaking Medicine Technology: