Navigation Links
Novel Technology to Locate and Treat Tumors

Research teams at Yale University and the University of Rhode Island have demonstrated a new way to target and potentially treat tumors using a short piece of protein that acts like a nanosyringe to deliver tags or therapy to cells, according to a report in the Proceedings of the National Academy of Sciences.

The researchers show that, the protein fragment, called pHLIP (pH (Low) Insertion Peptide) can be injected into the abdomen of a mouse, find its way into the blood and then specifically accumulate in tumors. Within 20 hours after injection of labeled pHLIP, the molecules had passed through the bloodstream and accumulated in mouse breast tumors grown to different stages on the leg of a mouse.

The researchers demonstrated that by attaching fluorescent probes to a pHLIP peptide, tumors could be detected. They expect that by attaching and delivering active agents with pHLIP, that tumors may be able to be treated. Targeting is based on the fact that most tumors, even very small ones, are acidic as a result of the way they grow.

Since the mechanism is general, and since even very small tumors can be targeted, there is an exciting array of possible applications for pHLIP, said Donald Engelman, Eugene Higgins Professor of Molecular Biophysics & Biochemistry at Yale and a co-author of the paper.

Andreev and Reshetnyak [co-authors of the paper] have taken a recent discovery from our lab and we are pushing hard as a team to test possible applications, said Engelman. We are very excited by the possibilities for both imaging and treating tumors.

The pHLIP molecule has three states: soluble in water, bound to the surface of a membrane, and inserted across the membrane as an alpha-helix. Under normal tissue conditions of neutral pH, the water-soluble form is favored. At acidic pH, the transmembrane alpha-helix predominates.

An earlier paper from the same groups shows that at low pH, pHLIP
'"/>




Page: 1 2

Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel Technology Locate and Treat Tumors

(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... wheat that boosts up the protein, zinc and iron ... that affect millions of children worldwide. Researchers at the ... the U.S. Department of Agriculture; and the University of ... the Nov. 24 issue of the journal Science. ...
... there is one more impact of a job burn out. ... also stir up a host of ailments, say Scientists. //This ... stress at work can contribute to high blood pressure, metabolic ... 677 workers in Israel revealed that risk of Type 2 ...
... School of Medicine have reported that genetics has a ... preemies//, a disease known to hamper the development of ... This report is published in the November issue of ... show that genetic factors are a significant component of ...
... Scientists at San Francisco, in the US, have announced ... positive results. // ,This treatment referred to as ... of brain cancer, termed glioma.Scientists at the University of ... mode of treatment involves isolating a protein gp96 from ...
... Vietnam, The Nha Trang Institute of Vaccines and Biological ... 5,000 doses of a H5N1 vaccine for// humans from ... on white mice, guinea-pigs and cockerels and similar reactions ... Institute of Verification of Vaccines and Biological Products. Its ...
... Michelle Hasni of Cutler Ridge, Miami, delivered a male child ... very rare congenital heart disorder called Ectopia// cordis. Seven or ... defect. ,The baby named Naseem, was born with ... and the protective cover for the heart called pericardium had ...
Cached Medicine News:Health News:Newly Cloned Wheat Gene May Boosts Foods' Nutrient Contents – Says A Researc 2Health News:Genetics Plays A Crucial Role In Preemies' Destructive Eye Disease 2Health News:Naseem’s Heart Put In Its Plac 2
(Date:12/24/2014)... HILL, N.C. , Dec. 23, 2014  Medical ... success. As the key link between the medical device ... grow even more in the coming years as the ... According to research by benchmarking firm, ... MSLs can gain an important edge is by harnessing ...
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014 ... into expanded corporate offices in Aliso Viejo ... announced that due to the tremendous growth and worldwide ... needed. Sales of patented SnoreRx, the anti snore cure ... offices. He said, "We are now in 23 ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and ... the addition of the "Investment Analysis of ... to their offering. ... in the US medical device sector identifies the ... and venture capital investments, and mergers and acquisitions. ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2Investment Analysis of the US Medical Device Sector 2
... Safety Concerns Raised ... NEW YORK, Dec. 5 Keryx Biopharmaceuticals,(Nasdaq: KERX ... (DSMC) responsible for monitoring Sulonex(TM) (sulodexide oral,gelcaps), the Company,s ... nephropathy, recently met to evaluate the data from,the ongoing ...
... N.J., Dec. 5 Senesco,Technologies, Inc. ("Senesco" or ... it has initiated preclinical lab studies at Mayo ... test the ability of,Senesco,s Factor 5A gene technology ... will evaluate delivery molecules for,encapsulation of Factor 5A ...
Cached Medicine Technology:Sulodexide Data Safety Monitoring Committee Completes Additional Review of Phase 3 Study Data 2Sulodexide Data Safety Monitoring Committee Completes Additional Review of Phase 3 Study Data 3Sulodexide Data Safety Monitoring Committee Completes Additional Review of Phase 3 Study Data 4Sulodexide Data Safety Monitoring Committee Completes Additional Review of Phase 3 Study Data 5Sulodexide Data Safety Monitoring Committee Completes Additional Review of Phase 3 Study Data 6Senesco Technologies Initiates Preclinical Studies for Cancer Target 2
... Size: 5.0 x 2.5 x 80 mm. Half ... by Harvey A. Lincoff, M.D. has been modified ... design. The material is a closed cell sponge ... with rounded edges to minimize scleral intrusion. These ...
... mm. Storz offers the original Scleral ... A. Lincoff, M.D. The material is ... non-toxic and non-antigenic. Implants are soft ... intrusion. These implants are packaged sterile ...
For use under curved implants. Indications: When additional buckling is required in the meridional direction. Overall length: 15.0 mm....
For use under silicone strips E5381 610, E5381 611 and E5381 710. Indications: When higher buckle is required. Overall length: 6.1 mm....
Medicine Products: