Navigation Links
Novel Techniques to Tackle Colon Cancer

A molecule that is implicated in 85 percent of colon cancer (carcinoma) cases has been discovered by the Researchers at University //of Utah's Huntsman Cancer Institute, which could be the possible target for treatment against colon cancers in the future.

Researchers were able to rescue zebra fish from the effects of a mutation in the adenomatous polyposis coli (APC) gene, by genetically disabling (undoing) a molecule called C-Terminal Binding Protein These findings appeared online published in the Journal of Biological Chemistry on October 6th 2006.

Mutations in this gene have been known to trigger a series of reactions, which eventually give rise to colon polyps, which ultimately become cancerous. APC mutations play a role in 85% colon cancers. The new findings mean CTBP also is involved in that proportion of colon cancers.

In zebra fish, APC mutations keep the intestine from developing properly. "In essence, knocking out CTPB promotes normal development of the intestine in zebra fish carrying an APC mutation," says David A. Jones, a University of Utah associate professor of oncological sciences and leader of the study.

In normal cells of both humans and zebra fish, the APC gene controls the amount of CTBP present by marking it for destruction. In tumor cells with mutated APC, CTPB is not destroyed; instead it accumulates in the cell.

One function of CTBP is to turn off the process that converts vitamin A into retinoic acid in the cell. Retinoic acid is essential in cell differentiation – the function that determines what type of cell forms and how long it lives. This study observed that in both zebra fish and human tissues with APC mutations, there are high CTBP levels and low capability to produce retinoic acid. In APC-mutated tissues in which CTBP had been "knocked out," retinoic acid production was restored.

Earlier studies in Jones' lab showed that lack of retinoic acid caused zebra fish
'"/>




Page: 1 2

Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel Techniques Tackle Colon Cancer

(Date:7/10/2014)... Up to 70% of Parkinson,s disease (PD) patients ... of life. Some patients have disturbed sleep/wake patterns ... while other patients may be subject to sudden ... PD patients may exhibit REM-sleep behavior disorder (RBD), ... even before motor symptoms appear. A review in ...
(Date:7/10/2014)... the human brain operates much the same whether active ... a better understanding of schizophrenia, bipolar disorder and other ... million Americans. , In newly published research in the ... at the Center for Molecular and Behavioral Neuroscience, determined ... rest is basically the same as that of a ...
(Date:7/10/2014)... Manchester scientists have shown that a new drug could prove ... aggressive form of lung cancer. , Scientists from the Cancer ... and part of the Manchester Cancer Research Centre, teamed up ... in 2010, to test a drug known as AZD3965 ... published in the journal Clinical Cancer Research , also ...
(Date:7/9/2014)... July 10, 2014 For the first time, researchers ... Aboriginal population in Canada uses health care. A new ... to clearly demonstrate the unique challenges faced by urban ... St. Michael,s Hospital. , The findings, published today ... urban First Nations individuals and the general population. , ...
(Date:7/9/2014)... hidden ways that cells are regulated, scientists at Rockefeller ... cells more likely to metastasize. , What,s more, the ... blocking two other proteins that are normally linked to ... could have unexpected ties. , The study, which ... , points to the possibility of new cancer therapies ...
Breaking Medicine News(10 mins):Health News:Sleep disturbances, common in Parkinson's disease, can be early indicator of disease onset 2Health News:Working to loosen the grip of severe mental illness 2Health News:New drug active against most aggressive type of lung cancer cells 2Health News:Urban Aboriginal people face unique health challenges 2Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3
... Alzheimer's disease and is connected to the same brain pathology. There ... cognitive decline the loss of memory and certain other aspects of ... a normal part of aging, others that it is an early ... it's a disease in its own right. ,A new ...
... the combination of just two genes, according to a new study ... of Clinical Endocrinology and Metabolism this week,// identifies one gene on ... height in men. These genes may also help explain why men ... of both of these genes you will be taller than a ...
... serum concentrations of estrogen and testosterone have about twice ... relatively low serum concentrations of these sex hormones. Associations ... breast cancer were not different in women who donated ... levels in these women were not a preclinical finding. ...
... A new US research has found that young women are ... young men.The study, which contradicts the stereotype that men// are ... The Annals of Internal Medicine this week. ,Researchers from ... years after they were discharged from hospital after a heart ...
... the liver from damage, according to new research from ... laboratory rats. //The rats were then given D-galactosamine, a ... synthesis and results in cell death. The rats fed ... ,The Researchers discovered three new compounds that might ...
... drugs called statins may reduce their risk of developing ... to offer// powerful protection against heart disease for people ... evidence to date that statin drugs may also help ... smaller study had suggested these drugs might offer some ...
Cached Medicine News:
(Date:1/15/2014)... Jan. 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, ... the Journal of Drugs in Dermatology (JDD) ... (ODAC). The event is January 17-20, 2014, at the Omni Orlando ... The ODAC is a distinguished event ...
(Date:1/15/2014)... Tegra Medical is very pleased to announce the appointment ... Chief Executive Officer.  Mark was promoted from his current role ... company,s four facilities in Massachusetts , ... Tegra Medical in 2012 with 20+ years of broad-based operations, ...
(Date:1/15/2014)... 15, 2014  According to Millennium Research Group (MRG), ... the United States and ... will expand moderately through 2022, with embolization particles ... increasing interest in drug-eluting beads (DEBs) and radioembolization ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... St. Jude scientists, findings in ataxia telangiectasia-like ... into the links between brain disease and ... Tenn., Jan. 14 Scientists ... teased apart the biological details distinguishing two ...
... first quarterKENILWORTH, N.J., Jan. 14 Schering-Plough Corporation (NYSE: ... Food and Drug Administration (FDA) has issued a complete ... acute treatment of schizophrenia in adults and in the ... bipolar I disorder in adults as monotherapy. The ...
Cached Medicine Technology:Study Shows How Defective DNA Repair Triggers Two Neurological Diseases 2Study Shows How Defective DNA Repair Triggers Two Neurological Diseases 3U.S. FDA Issues Complete Response Letter for SAPHRIS(TM) (ASENAPINE) in the Acute Treatment of Both Schizophrenia and Bipolar I Disorder 2
A system for the removal and filtration of laser and surgical smoke....
The FreedomAire Surgical Helmet System is a lightweight, comfortable helmut system with superior air flow, and a removable motor module that lifts off for easy cleaning....
...
... contains these disposable, silver/silver chloride ... separated into eight tabs), two ... patient use only. Starter kit ... red and black, one green ...
Medicine Products: