Navigation Links
Novel Technique For Targeting Small-Cell Lung Cancer

Small-cell lung cancer (SCLC), accounting for about 20% of all lung cancers, is a particularly aggressive form of malignancy// with about 80% of cases presenting in advanced stages. Early, accurate detection of SCLC, before it becomes systemic, is essential for successful treatment.

Tumor targeting with specific carriers is a promising approach that can significantly enhance the diagnostic power of imaging techniques by increasing contrast between malignant and normal tissues.

Fluorescence-based imaging provides safe, sensitive detection of malignancies. Targeted delivery of fluorophores increases sensitivity of endoscopic imaging. Conjugation of somatostatin analogs with fluorescent agents enables tumor detection by optical imaging techniques including endoscopy. The main advantages of this method are high sensitivity and outstanding spatial resolution.

In a recent work, researchers from Israel used novel backbone cyclic peptides, which function as Somatostatin receptor (SSTR) binding, tumor-targeting vectors. They synthesized novel somatostatin analogs, based on backbone cyclic peptides, and conjugated them with fluorescent agents. Nineteen conjugates differing in core peptide, length of alkyl linker and fluorescence moiety (rhodamine and fluorescein) were tested in vitro, using a receptor binding assay, and nine of the more promising conjugates were tested in vivo by fiber-optic spectrofluorimetry and quantitative spectral imaging, on an H69 human SCLC tumor mouse xenograft model.

The lead compound showed exceptional tumor/normal tissue ratios, ranging from 9 to 90, and had potential for targeting SCLC overexpressing somatostatin receptors.

The results of the study, presented in the journal Lung Cancer (available online 12 September 2005) demonstrate, for the first time, that human SCLC can be specifically targeted with high selectivity by a fluorescent bioconjugate of somatostatin analog, providing unmatched T/NT r atios.

Medindia on Lung cancer:

Lung cancer is the uncontrolled growth of abnormal cells in the lung. Majority of people who get lung cancer have been cigarette smokers, but not all people who smoke get lung cancer. And, some people who have never smoked get lung cancer. Normal lung tissue is made up of cells that are programmed by nature to create lungs of a certain shape and function.

Related medicine news :

2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:

(Date:10/13/2015)... Angeles, CA (PRWEB) , ... October 13, 2015 , ... ... To incentivize would-be customers, eMarketing Concepts began a $1 promotion – effectively offering all ... a resounding success, and within weeks the company was flooded with phone calls from ...
(Date:10/13/2015)... ... , ... The Bill Howe Family of Companies is an award winning HVAC ... remediation services. Family-owned and operated for 35 years, they have maintained value, ethics and ... two years in a row from the Union Tribune Reader’s Poll, a Healthiest Company ...
(Date:10/12/2015)... ... 2015 , ... Heroes in Recovery (HIR) is proud to ... Network’s Moments of Change conference in West Palm Beach, Florida. Rob Waggener, CEO ... Dauphinais who exemplify the ideals of the Heroes in Recovery movement. , Noah ...
(Date:10/12/2015)... , ... October 12, 2015 , ... Kevin Costello, winner of the “Check-In and Win ... embarks today for his dream vacation to Hawaii. , “I didn’t believe I could win ... says. “This contest encouraged me to get to the gym and invest in my own ...
(Date:10/12/2015)... ... 12, 2015 , ... The American Society of Clinical Hypnosis ... education and clinical training in a health care discipline. , Many practitioners ... as: losing weight, managing pain, or stopping smoking, etc. Frequently, extravagant statements and ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), ... Therapy Catapult to advance development of large scale ... immunotherapy. Under the agreement, the Cell Therapy Catapult ... to support advanced clinical trials and eventual commercialization ... --> The Cell Therapy Catapult is a ...
(Date:10/12/2015)... WASHINGTON , Oct. 12, 2015  Former White House ... Press Secretary for the House Narcotics Committee, Robert Weiner ... "Rewriting Drug Policy." The two emphasize that this is now ... Clinton to Jeb Bush , Carly Fiorina ... Sordello cite the newest federal statistics, which they call "a ...
(Date:10/12/2015)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), the leading ... processes to develop and market advanced products and therapies ... Ophthalmic, and the Dental sectors of healthcare, announced today ... 2015, its guidance for the fourth quarter of 2015, ... Senior Secured Credit Facility. --> ...
Breaking Medicine Technology: