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Novel Technique Can Enhance Stem Cell Multiplication By 30 Fold

population was observed when the hematopoietic cells were mixed with purified IGF-2.

Abundant expression of two other factors called Angiopoietin-like 2 (angpt12) and Angiopoietin-like –3 (angpt13) were also found. When these components were mixed with IGF-2, a 30-fold increase in the stem cell multiplication could be seen.

Stem cell therapy in the form of bone marrow transplantation remains a viable, life-saving option for patients with hematological malignancies. The stem cells can either be obtained from the bone marrow or even cord blood, though the latter is most commonly used. If this finding can be applied to the isolate, then perhaps, we could have adequate stem cells to treat a particular patient.

Gene therapy is yet another area, where the above finding can be useful. Issues related to the possibility of carcinogenesis as a consequence of gene therapy has to a large extent restricted the approval of any gene-therapy clinical trials.

The study has led to an improved understanding of the stem cell biology, stem cell therapy and research. The researchers are further interested in knowing whether similar results can be obtained for human cord blood as well.
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