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Novel Delivery Method of Insulin Gene to Combat Juvenile Diabetes Developed

an integrase to insert the insulin gene into the patients gut cells.

Gene delivery by these nanoparticles is expected to be safer and less immunogenic than more commonly used virus-based agents. In the preclinical testing reported in this conference, a single administration of the nanoparticles induced the production of insulin in the recipients for over 130 days. Moreover, the insulin production was responsive to meals.

Work is currently underway to support an Investigational New Drug filing with the FDA, anticipated by late 2008 or early 2009, after which the team plans to test these nanoparticles in individuals suffering from diabetes.


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