( A safer method to deliver the insulin g...)Novel Delivery Method of Insulin Gene to Combat Juvenile Diabetes Developed,Health

A safer method to deliver the insulin gene to diabetes patients using nanoparticles, was presented today at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle.

Type 1 or juvenile diabetes is caused by autoimmune destruction of the insulin producing pancreatic -cells. As a result of the loss of insulin, blood sugar levels rise too high, causing damage to fine blood vessels and nerve endings leading to debilitating symptoms. As a result patients become dependent upon daily insulin injections to survive. However, it is virtually impossible to match the sugar content of each meal with the optimal dose of insulin the cumulative mistakes severely reduce both the quality and length of life.

Recreating appropriately regulated internal insulin secretion in surrogate cells (i.e. non--cells) in individuals with diabetes is an attractive approach to cure this disease. A major hurdle with this approach has been replicating automatic insulin secretion that is tuned to the bodys requirements.

Dr. Anthony Cheung and his colleagues at enGene, Inc., Vancouver, aim to develop an approach to restore the meal-responsive insulin production and release capability in individuals with diabetes, thereby eliminating the need for insulin injections while also improving control of blood sugar levels.

They intend to achieve this by inducing specific cells of the gut to take over production of insulin. The team previously reported that gut K-cells can be induced with the insulin gene to produce insulin in response to meal ingestion in a pattern comparable to normal insulin production from the pancreas.

In order to translate this technology to clinical use, the team developed a novel method to deliver the insulin gene to the target K-cells in the gut using nanoparticles. The nanoparticles contain a component called chitosan that provides protection to the insulin gene while in the gut as well as
'"/>




Page: 1 2
Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals