Navigation Links
Novel Biological Pacemaker Under Construction for Weak Hearts

Johns Hopkins scientists have developed a natural or rather biological pacemaker by fusing connective tissue cells of guinea pigs with heart muscle cells. The newly developed pacemaker can fire on it’s own and regulate the rhythm // of the heart in a more physiological way.

Two sets of tiny electroactive 'pacing cells' (SA node) give rise to the heart’s normal rhythm by stimulating other cells to contract in certain sequences. Potentially fatal arrythmias occur when these pacing cells are damaged or die. Pacemaker implantation is lifesaving in groups of patient tolerant to the device.

The invention of the first external cardiac pacemaker by Canadian Researcher, John Hopps in 1950 is a milestone worth remembering in this regard. From what was known at that time, we have indeed come a long way in the development of the biological pacemaker.

The researchers successfully combined regular heart muscle cells having no pacing abilities with fibroblasts modified by a gene (HCN1) to help in the transmission of electrical signals. The fibroblasts were taken from the animals’ lungs. Following three minutes of cell fusion, the derived cell showed the desired activity of producing it’s own electric current. The cells behaved very similar to the natural cardiac pacemaker cells and were viable for 2 weeks.

Subsequently, the introduction of these cells into the ‘weakened’ animal hearts revealed successful incorporation into the heart muscle cells. Infact, the heart rate quadrupled to nearly half-normal levels. These cells retained the property of firing spontaneously, a hallmark of pacing cells normally found in the heart.

The disadvantages of the currently available electronic pacemaker include the necessity for periodic battery replacement, an implantation of a permanent tube (catheter) in the chest to ensure access to the pacemaker. The risk of infection is also much high due to the need for embedding diodes to carry ele ctric current inside the heart.

Other biopacemaker technologies use adenoviruses as part of gene therapy to carry pacing genes into the heart, or use combinations of gene- and stem cell therapies. This can cause arrythmias as the result of inflammation or uncontrolled cell growth. Moreover, guiding the stem cells into the target tissue is one of technical hurdles to be circumvented.

The biological pacemaker has numerous advantages over the conventional one in the sense it can serve as an ideal alternative in infection-prone patients or who are physically too weak to have a mechanical pacemaker implanted. Moreover, fibroblasts are found throughout the body, even in skin. These construction blocks are much easier to grow and handle in the lb.
'"/>




Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... City, Missouri (PRWEB) , ... April 29, 2016 , ... ... traditional crutches which put pressure on the armpits, the M+D Crutch evenly distributes body ... strain on their wrists and hands when using the crutches than with other crutches. ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... Canadian Celiac Association (CCA), is pleased to announce the launch of the ... nutritional articles, recipes, and more. The purpose of the GFCP Scoop ...
(Date:4/29/2016)... ... 29, 2016 , ... Dr. Robert Mondavi, one of the dentists in ... is a fast-growing field as more patients are discovering the many different ways they ... the options currently available to them and which ones might work for their smiles. ...
(Date:4/29/2016)... ... April 29, 2016 , ... Reltok Nasal Products proudly announces ... the head and neck/ear, nose and throat specialty, has added the KOTLER NASAL AIRWAY™ ... NASAL AIRWAY™ is a newly patented safety device secured by nasal surgeons onto ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... of a growth round of funding led by Eastside Partners, with participation from ... company’s rapidly growing customer base and accelerate its technology and product roadmap. ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... Glycotope GmbH, a clinical-stage immuno-oncology ... appointment of Dr. Alfredo Zurlo as Chief ... with many years clinical experience and a proven track ... role was at Mologen AG where he was Chief ... Dr. Zurlo held various positions at F Hoffmann La ...
(Date:4/28/2016)... NEW YORK , April 28, 2016 /PRNewswire/ ... will notably complement the company,s valve repair and ... the move also places Abbott more firmly into ... one of the fastest growing device areas, with ... to its recent report,  Advanced Remote Patient ...
(Date:4/28/2016)... 28, 2016 ... Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter Softwarelösungen ... bekannt, dass neue Führungskräfte zum Team Sicherheit ... die vielfältige Erfahrungen mitbringen.  Dies wird die ...
Breaking Medicine Technology: