Navigation Links
Novel Biological Pacemaker Under Construction for Weak Hearts

Johns Hopkins scientists have developed a natural or rather biological pacemaker by fusing connective tissue cells of guinea pigs with heart muscle cells. The newly developed pacemaker can fire on it’s own and regulate the rhythm // of the heart in a more physiological way.

Two sets of tiny electroactive 'pacing cells' (SA node) give rise to the heart’s normal rhythm by stimulating other cells to contract in certain sequences. Potentially fatal arrythmias occur when these pacing cells are damaged or die. Pacemaker implantation is lifesaving in groups of patient tolerant to the device.

The invention of the first external cardiac pacemaker by Canadian Researcher, John Hopps in 1950 is a milestone worth remembering in this regard. From what was known at that time, we have indeed come a long way in the development of the biological pacemaker.

The researchers successfully combined regular heart muscle cells having no pacing abilities with fibroblasts modified by a gene (HCN1) to help in the transmission of electrical signals. The fibroblasts were taken from the animals’ lungs. Following three minutes of cell fusion, the derived cell showed the desired activity of producing it’s own electric current. The cells behaved very similar to the natural cardiac pacemaker cells and were viable for 2 weeks.

Subsequently, the introduction of these cells into the ‘weakened’ animal hearts revealed successful incorporation into the heart muscle cells. Infact, the heart rate quadrupled to nearly half-normal levels. These cells retained the property of firing spontaneously, a hallmark of pacing cells normally found in the heart.

The disadvantages of the currently available electronic pacemaker include the necessity for periodic battery replacement, an implantation of a permanent tube (catheter) in the chest to ensure access to the pacemaker. The risk of infection is also much high due to the need for embedding diodes to carry ele ctric current inside the heart.

Other biopacemaker technologies use adenoviruses as part of gene therapy to carry pacing genes into the heart, or use combinations of gene- and stem cell therapies. This can cause arrythmias as the result of inflammation or uncontrolled cell growth. Moreover, guiding the stem cells into the target tissue is one of technical hurdles to be circumvented.

The biological pacemaker has numerous advantages over the conventional one in the sense it can serve as an ideal alternative in infection-prone patients or who are physically too weak to have a mechanical pacemaker implanted. Moreover, fibroblasts are found throughout the body, even in skin. These construction blocks are much easier to grow and handle in the lb.
'"/>




Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
Breaking Medicine Technology: