Navigation Links
Novel Biological Pacemaker Under Construction for Weak Hearts

Johns Hopkins scientists have developed a natural or rather biological pacemaker by fusing connective tissue cells of guinea pigs with heart muscle cells. The newly developed pacemaker can fire on it’s own and regulate the rhythm // of the heart in a more physiological way.

Two sets of tiny electroactive 'pacing cells' (SA node) give rise to the heart’s normal rhythm by stimulating other cells to contract in certain sequences. Potentially fatal arrythmias occur when these pacing cells are damaged or die. Pacemaker implantation is lifesaving in groups of patient tolerant to the device.

The invention of the first external cardiac pacemaker by Canadian Researcher, John Hopps in 1950 is a milestone worth remembering in this regard. From what was known at that time, we have indeed come a long way in the development of the biological pacemaker.

The researchers successfully combined regular heart muscle cells having no pacing abilities with fibroblasts modified by a gene (HCN1) to help in the transmission of electrical signals. The fibroblasts were taken from the animals’ lungs. Following three minutes of cell fusion, the derived cell showed the desired activity of producing it’s own electric current. The cells behaved very similar to the natural cardiac pacemaker cells and were viable for 2 weeks.

Subsequently, the introduction of these cells into the ‘weakened’ animal hearts revealed successful incorporation into the heart muscle cells. Infact, the heart rate quadrupled to nearly half-normal levels. These cells retained the property of firing spontaneously, a hallmark of pacing cells normally found in the heart.

The disadvantages of the currently available electronic pacemaker include the necessity for periodic battery replacement, an implantation of a permanent tube (catheter) in the chest to ensure access to the pacemaker. The risk of infection is also much high due to the need for embedding diodes to carry ele ctric current inside the heart.

Other biopacemaker technologies use adenoviruses as part of gene therapy to carry pacing genes into the heart, or use combinations of gene- and stem cell therapies. This can cause arrythmias as the result of inflammation or uncontrolled cell growth. Moreover, guiding the stem cells into the target tissue is one of technical hurdles to be circumvented.

The biological pacemaker has numerous advantages over the conventional one in the sense it can serve as an ideal alternative in infection-prone patients or who are physically too weak to have a mechanical pacemaker implanted. Moreover, fibroblasts are found throughout the body, even in skin. These construction blocks are much easier to grow and handle in the lb.
'"/>




Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/20/2017)... LOS ANGELES, Calif. (PRWEB) , ... August 20, 2017 , ... A total solar ... to darken for a few minutes as the moon moves between the sun and Earth. ... drivers? , These four tips can help keep you safe on the road during ...
(Date:8/20/2017)... , ... August 20, 2017 , ... Are you an ... household? If so, you may be interested in participating in a research study ... this research is to understand more about the relational aspects of adults who have ...
(Date:8/19/2017)... ... August 18, 2017 , ... ... at creating a transparent, verifiable database to help the cannabis industry move towards ... Paragon hopes to deliver a faster technology with lower fees. Paragon will build ...
(Date:8/19/2017)... ... 2017 , ... Curl Keeper® is excited to announce that the H2O Water ... Award for the second year in a row. The H2O Bottle, a refillable ultra-fine ... Best Moisturizer for Type 2 Wavies and Best Refresher for Type 2 Wavies in ...
(Date:8/19/2017)... Dayton, NJ (PRWEB) , ... August 19, 2017 ... ... Highland Park, NJ, is a diverse community of over 1,000 passionate employees, caregivers, ... the aging. After Parker at Stonegate changed ownership, it was time to refresh ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017 AccuGenomics, Inc., a diagnostic ... today announced that the company has provided an AccuKit ... North Carolina at Chapel Hill and to Qura Therapeutics ... characterize and quantify HIV reservoir and viral expression in ... The HIV Cure Center is a joint initiative between ...
(Date:8/14/2017)... and PETACH TIKVAH, Israel , Aug. ... a leading developer of adult stem cell technologies for ... ending June 30, 2017. ... for our pivotal Phase 3 trial to investigate NurOwn ... President and Chief Executive Officer of BrainStorm. "We have ...
(Date:8/10/2017)... -- Physical Rehabilitation Network (PRN), acquired the long-standing outpatient rehabilitation clinic, ... . The reputable clinic will continue to be co-owned and ... staff of four clinicians. Lipkin received his doctorate in physical ... years of experience with a strong background in manual therapy. ... 10th PRN clinic in and around the Denver ...
Breaking Medicine Technology: