Navigation Links
Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients

A recent three-way crossover study over six weeks by clinicians at the National Heart and Lung Institute, Royal Brompton Hospital, London has shown that Salmeterol produced a novel anti-neutrophilic effect among patients with mild asthma. The study was prompted by the long standing argument about the effects of long-acting beta2-adrenergic receptor agonists, such as salmeterol, on inflammation. The clinicians enrolled 20 patients, between the ages// of 18 and 55, with mild stable asthma who were randomized to receive salmeterol (50 micrograms b.d), fluticasone propionate (250 micrograms b.d), or placebo. They investigated the effect of salmeterol on the numbers of inflammatory cells in biopsy samples of distinct immuno-phenotype and those expressing the genes for interleukin-4 and -5, regulatory cytokines which are particularly relevant to asthma.

The numbers of neutrophils in bronchial biopsy samples and the concentrations of myeloperoxidase and soluble E-selectin in serum, each of which reflect neutrophil involvement, was found to be significantly reduced in subjects who were given salmeterol compared to those who were given the placebo. Salmeterol, compared with fluticasone propionate, reduced neutrophil number and human neutrophil lipocalin level in bronchial lavage fluid, and intercellular adhesion molecule-1 level in bronchoalveolar lavage fluid. It was also observed that the numbers of (CD3+) T-lymphocytes, (CD4+) T-helper cells, (CD45RO+) activated T-helper cells and eosinophils in the biopsy samples were significantly reduced with fluticasone propionate, compared with placebo. Fluticasone propionate also reduced the percentage of eosinophils and soluble intercellular adhesion molecule-1 in serum.

The clinicians also found that after the use of salmeterol, as compared with both fluticasone propionate and placebo, the airways hyper-responsiveness and the percentage of symptom-free days and nights improved significantly.


'"/>




Page: 1

Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Therapy for Chronic Problem
8. Blood Sugar Kept In Control By Novel Protein
9. Novel antibiotic dressing developed for improved wound healing
10. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
11. Novel drug holds promise for treatment of Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
Breaking Medicine Technology: