Navigation Links
Novartis Gleevec Found Effective in Treating Gastro-intestinal Tumors

The US-based National Cancer Institute (NCI) has commended Novartis' anti-cancer tablet, Gleevec, as an// effective therapy for patients suffering from GISTs, metastatic gastro-intestinal tumors.

These tumours do have a rather complicated name. They are found in the digestive system - the gastrointestinal tract. They develop from cells of connective tissues that control the movements of the gut.

The tissues that support body organs are called the 'stroma', so that's where the stromal bit comes from. Cancers of connective tissues are 'sarcomas'. So the full name is gastrointestinal stromal sarcoma.

Some GISTS are benign (not cancerous) but they can become cancerous if not treated. Generally speaking, the larger the GIST, the more likely it is to be cancerous. It is estimated that approximately 5,000 to 6,000 new patients are diagnosed with GIST each year in the United States.

The NCI said that preliminary results from a large, randomized, placebo-controlled clinical trial for patients with primary GIST, showed that patients who received imatinib mesylate (Gleevec) after complete removal of their tumor were significantly less likely to have a recurrence of their cancer compared to those who did not receive imatinib. There was no recurrence of cancer in approximately 97 per cent of patients given Gleevec for a year after surgery to remove tumors, compared to approximately 83 per cent of those who underwent surgery but received a placebo.

The Novartis has lately come under a lot of fire over its continuing battle in Indian courts to patent Gleevec. In such a backdrop, the NCI's preliminary findings should be welcome for it.

Novartis supplied Gleevec for use in the study involving 600 patients, and also provided partial funding under a cooperative research and development agreement with NCI to support the clinical development of Gleevec.

"These results have major implica tions for patients with primary GIST," noted the principal investigator of the study, Ronald DeMatteo, Memorial Sloan-Kettering Cancer Center at New York.

"Conventional chemotherapy agents have been notoriously ineffective in GIST. This study for the first time demonstrated that targeted molecular therapy reduces the rate of recurrence after complete removal of a primary GIST."

Diane Young, Head of Global Medical Affairs at Novartis Oncology, said, "With these new data, we see that Gleevec may help patients with early GIST. We will now work with the investigators on a submission to gain regulatory approval for Gleevec as adjuvant treatment for GIST."

Adjuvant therapy is treatment given in addition to the primary therapy to kill any cancer cells that may have spread, even if the spread cannot be detected by radiologic or laboratory tests.
GPL/V
'"/>




Related medicine news :

1. Novartis files application with FDA for Zometa
2. Canine Painkiller unveiled by Novartis
3. Glivec the hot cancer drug from Novartis
4. Zometa [Novartis Drug] For Treatment Of Paget’s Diseas
5. Novartis MS Drug Shows Promising Results
6. Bird-flu Vaccine Adjuvant Contract Goes to Novartis
7. Drop Patent Petition, Activists Ask Novartis
8. E.U. Panel Backs Novartis Mock-up Pandemic Flu Vaccine
9. Indian Court Refers Novartis Plea for Patent on Anti-cancer Drug to a Separate Board
10. Novartis Drug Diovan Shows Superior Benefits
11. Gleevec gets hopeful results
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
Breaking Medicine Technology: