Navigation Links
Not Parkinson’s Disease Alon

Scientists claim that sequence variation in a gene linked to dopamine regulation, can lead not only to Parkinson’s disease but also to a craving for alcohol.//

The protein alpha synuclein (SNCA) plays an important role in the regulation of dopamine function. SNCA mutations can lead to significant problems, such as the neurodegenerative disorder Parkinson's disease, which is caused by a substantially reduced production of dopamine.

New findings show that sequence variation in the SNCA gene also contributes to whether or not an individual craves or does not crave alcohol.

Results are published in the April issue of Alcoholism: Clinical & Experimental Research.

"Several years ago," explained Tatiana M. Foroud, director of the division of Alcoholism: Clinical & Experimental Research, "animal researchers identified a gene called SNCA, which appeared to contribute to the alcohol-drinking patterns of specially bred rats. Further studies have shown that different levels of SNCA exist in the brains of rodents that prefer alcohol versus those who do not like alcohol."

Since then, added corresponding-author Foroud, human research has suggested that SNCA might be important in determining an individual's craving for alcohol. "Using previous research as a building base," she said, "we utilized a large sample, a different type of analysis technique, and genotyped more sequence variants in the gene to provide a more comprehensive survey of the role of this gene in the craving for alcohol and alcoholism."

Foroud and her colleagues examined a sample of 219 alcoholic families of European American descent. Thirty single nucleotide polymorphisms (SNPs) were genotyped across the SNCA gene, and two phenotypes – alcohol dependence and alcohol craving – were also analyzed.

Although findings indicate no association between any of the SNCA SNPs and alcohol dependence, eight SNPs did have an association with alcohol c raving.

"This strongly suggests that sequence variation in SNCA contributes to whether an individual craves or does not crave alcohol," said Foroud. "Interestingly, we found that this association cannot be expanded to everyone who has alcohol dependence. Rather, it seems to be limited to that subset of alcoholics who also indicate that they crave alcohol when they do not have the ability to obtain it."

"The strongest evidence for association was observed in a region encompassing one particular end of the gene," said Alison Goate, professor of psychiatry, genetics and neurology, at Washington University. "This is interesting because it appears to confirm a previous association between SNPs in the same region of the rat SNCA gene that differ between alcohol-preferring and non-preferring rats. It is this subgroup of alcoholics who have cravings that seem to be influenced by variation in the SNCA gene."

Foroud said that this study supports the emerging belief in the alcohol-research field that there are "subtypes" of alcoholics, in this case, a subset of individuals in whom variation in SNCA is an important contributor to the risk of developing alcoholism.

"Understanding the role of SNCA in sensitivity to craving may enable the future development of drugs to help alleviate the symptoms of craving," added Goate, "improving the chances that an individual might be able to stop drinking."

"Alcoholism is a complex disorder and we are identifying pieces of the puzzle that help us to understand why some individuals develop alcohol dependence and others do not," said Foroud. "The role of SNCA is only one of these pieces."


Related medicine news :

1. NPIL withdraws Parkinson’s dru
2. Parkinson’s Drug Linked to Gamblin
3. Delaying Parkinson’s Diseas
4. New Drug For Parkinson’s Disease With Less Side Effect
5. Embryonic Cells Might Prevent Parkinson’s Disease From Worsenin
6. Magnetic Stimulation For Parkinson’s Diseas
7. Exercising regularly can reduce the risk of Parkinson’s diseas
8. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
9. New Medicine For Parkinson’s disease
10. A New Addition Could Help Patients With Parkinson’s Disease
11. Milk intake increases the risk of Parkinson’s disease in midlife
Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
(Date:9/27/2017)... Israel and NEW YORK , Sept. 27, ... with mobile health and big data solutions, today announced that its MyDario ... Please check your local TV listings for when The Dr. Oz Show ... ... season this month. ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
Breaking Medicine Technology: