Navigation Links
Not Parkinson’s Disease Alon

Scientists claim that sequence variation in a gene linked to dopamine regulation, can lead not only to Parkinson’s disease but also to a craving for alcohol.//

The protein alpha synuclein (SNCA) plays an important role in the regulation of dopamine function. SNCA mutations can lead to significant problems, such as the neurodegenerative disorder Parkinson's disease, which is caused by a substantially reduced production of dopamine.

New findings show that sequence variation in the SNCA gene also contributes to whether or not an individual craves or does not crave alcohol.

Results are published in the April issue of Alcoholism: Clinical & Experimental Research.

"Several years ago," explained Tatiana M. Foroud, director of the division of Alcoholism: Clinical & Experimental Research, "animal researchers identified a gene called SNCA, which appeared to contribute to the alcohol-drinking patterns of specially bred rats. Further studies have shown that different levels of SNCA exist in the brains of rodents that prefer alcohol versus those who do not like alcohol."

Since then, added corresponding-author Foroud, human research has suggested that SNCA might be important in determining an individual's craving for alcohol. "Using previous research as a building base," she said, "we utilized a large sample, a different type of analysis technique, and genotyped more sequence variants in the gene to provide a more comprehensive survey of the role of this gene in the craving for alcohol and alcoholism."

Foroud and her colleagues examined a sample of 219 alcoholic families of European American descent. Thirty single nucleotide polymorphisms (SNPs) were genotyped across the SNCA gene, and two phenotypes – alcohol dependence and alcohol craving – were also analyzed.

Although findings indicate no association between any of the SNCA SNPs and alcohol dependence, eight SNPs did have an association with alcohol c raving.

"This strongly suggests that sequence variation in SNCA contributes to whether an individual craves or does not crave alcohol," said Foroud. "Interestingly, we found that this association cannot be expanded to everyone who has alcohol dependence. Rather, it seems to be limited to that subset of alcoholics who also indicate that they crave alcohol when they do not have the ability to obtain it."

"The strongest evidence for association was observed in a region encompassing one particular end of the gene," said Alison Goate, professor of psychiatry, genetics and neurology, at Washington University. "This is interesting because it appears to confirm a previous association between SNPs in the same region of the rat SNCA gene that differ between alcohol-preferring and non-preferring rats. It is this subgroup of alcoholics who have cravings that seem to be influenced by variation in the SNCA gene."

Foroud said that this study supports the emerging belief in the alcohol-research field that there are "subtypes" of alcoholics, in this case, a subset of individuals in whom variation in SNCA is an important contributor to the risk of developing alcoholism.

"Understanding the role of SNCA in sensitivity to craving may enable the future development of drugs to help alleviate the symptoms of craving," added Goate, "improving the chances that an individual might be able to stop drinking."

"Alcoholism is a complex disorder and we are identifying pieces of the puzzle that help us to understand why some individuals develop alcohol dependence and others do not," said Foroud. "The role of SNCA is only one of these pieces."

Source-Eurekalert
AN
'"/>




Related medicine news :

1. NPIL withdraws Parkinson’s dru
2. Parkinson’s Drug Linked to Gamblin
3. Delaying Parkinson’s Diseas
4. New Drug For Parkinson’s Disease With Less Side Effect
5. Embryonic Cells Might Prevent Parkinson’s Disease From Worsenin
6. Magnetic Stimulation For Parkinson’s Diseas
7. Exercising regularly can reduce the risk of Parkinson’s diseas
8. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
9. New Medicine For Parkinson’s disease
10. A New Addition Could Help Patients With Parkinson’s Disease
11. Milk intake increases the risk of Parkinson’s disease in midlife
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... ... , ... The Global Wellness Summit (GWS), an annual conference for ... wellness, travel, spa and beauty in Europe. The organization asked its partner experts in ... and researchers - to forecast where wellness is headed in Europe. Predictions range from ...
(Date:5/31/2016)... ... May 31, 2016 , ... Interest is on the ... tool and as an orthogonal tool for RNAi hit validation. A key reason may ... guide RNAs—allows rapid generation of CRISPR RNA (crRNA) collections in arrayed formats. , ...
(Date:5/31/2016)... ... , ... Dr. Charles A. Ditta attained his Doctor of Medical Dentistry Degree ... 1986, where he graduated in the top ten percentile of his class. Dr. Ditta ... He has been a member in good standing for thirty years in the American ...
(Date:5/30/2016)... ... May 30, 2016 , ... As the CDC relaxes its stance on traditional ... to keep their households lice free. , According to a May 26 article ... keep kids in the classroom despite the fact that they may be harboring an ...
(Date:5/29/2016)... ... ... Whole Health Supply is happy to announce the favorable reception of its ... new style of nail clipper has a wider jaw opening that is useful for ... actual handle is 2.5mm thick to accommodate the cutting force. This is the maximum ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... , May 30, 2016 ... H1 2016" market research report with comprehensive information ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:5/27/2016)... 2016 Hutchison China MediTech ... on the highly lucrative global oncology and immunology ... potential first-in-class or best-in-class tyrosine kinase inhibitor (TKI) ... strategic partners. HCM,s profitable Chinese healthcare business continues ... expect progress of the mid-to-late-stage pipeline during 2016-17 ...
(Date:5/26/2016)... 2016 A key trend that ... emergence of new treatments. Cardax, a development stage life ... The therapy is expected to fulfil large unmet medical ... conducting studies to develop new treatments for osteoarthritis. One ... involved in osteoarthritis are being investigated, and early trials ...
Breaking Medicine Technology: