Navigation Links
Non Hormonal Therapies for Menopause Not Proved to be Effective

Previously published studies which examined the use of nonhormonal therapies for the treatment of menopausal hot flashes, have been subjected to a meta analysis. // This has revealed the efficacy of a few therapies but not as effective as estrogen. In addition they might have possible adverse effects which could restrict their use.

The results of the analysis have been published in the May 3 issue of JAMA.

Hot flashes are the most common symptom related to menopausal transition. They are experienced by more than 50 percent of menopausal women, can persist for several years after menopause, and for some women can interfere with activities or sleep to such a degree that treatment is requested, according to background information in the article. Estrogen has been used as a hormone supplement for nearly 60 years to treat menopausal symptoms. However, recent studies reporting adverse effects such as cardiovascular events and breast cancer have raised important concerns about its use and have led to increased interest in other therapies for improving menopausal symptoms. Evidence of the efficacy and adverse effects of nonhormonal therapies is generally lacking or unclear.

Heidi D. Nelson, M.D., M.P.H., of the Oregon Health and Science University and Providence Health System, Portland, Ore., and colleagues conducted a meta-analysis of randomized controlled trials to compare the efficacy and adverse effects of nonhormonal therapies for menopausal hot flashes. The researchers identified 43 relevant trials, including 10 trials of antidepressants, 10 trials of clonidine, 6 trials of other prescribed medications, and 17 trials of isoflavone extracts.

The researchers found: “This systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials of nonhormonal therapies provides supportive evidence for the efficacy of selective serotonin reuptake inhibitors (SSRIs) or serotonin noradrenergic reuptake inhibitor s (SNRIs) [such as paroxetine, venlafaxine, fluoxetine and citalopram], clonidine, and gabapentin in reducing the frequency and severity of menopausal hot flashes based on a small number of fair and good [quality] trials (SSRIs or SNRIs and gabapentin) or poor and fair [quality] trials (clonidine). The trials do not support the efficacy of red clover isoflavone extracts and present mixed results for soy isoflavone extracts. Evidence for other therapies is limited due to the small number of trials and their deficiencies. Few trials compare different therapies head-to-head and relative efficacy cannot be determined.”

“Despite increasing interest in therapies for menopausal hot flashes that avoid use of estrogen, the efficacy and safety of other options currently are not well supported. The SSRIs or SNRIs, clonidine, and gabapentin provide some evidence of efficacy. However, effects are less than those for estrogen therapy, few trials have been published and most have methodological deficiencies, and generalizability beyond the small clinical populations studied could be limited. Adverse effects and cost may prohibit use for many women. Although these therapies may be most useful for highly symptomatic women who cannot take estrogen, they are not optimal choices for most women,” the authors conclude.

'"/>




Related medicine news :

1. Viagra Halves Effect Of Hormonal Stress On Heart
2. Hormonal Changes in Girls Increase Their Risk of Insomnia
3. Hormonal Changes Causes Older Women To Have Twins
4. Non-Hormonal Male Contraceptive Based on Sperm Block Underway
5. Medication Abuse In Chronic Migraine May Cause Hormonal Abnormalities
6. Herceptin + Hormonal Therapy Pack Reduces Breast Cancer Progression
7. Stress – Buster : Hormonal Nasal Spra
8. Males too Undergoes Hormonal Changes During Parenting: Study
9. Combination of Herceptin and Hormonal therapy to Fight Cancer
10. Male Contraceptive Drug - Non Hormonal Alternative
11. NIMH Studies Woman’s Hormonal Cycl
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... Angeles, CA (PRWEB) , ... February 23, 2017 , ... ... her Smiling Patriot program today with a new Indiegogo campaign . ... care to homeless veterans in the Los Angeles area, either as a participating patient ...
(Date:2/23/2017)... CHURCH, Va. (PRWEB) , ... February 23, 2017 , ... ... worries, or problems. He has also continued to spiritually evolve, which is the purpose ... published book “ Our Spiritual Truths ” (published by Balboa Press) attempts to guide ...
(Date:2/22/2017)... Tampa, Fla. (PRWEB) , ... February 22, 2017 ... ... the field of regenerative medicine in recent years. The technology is so cutting ... sanction regulations on the protocol for stem cell procedures. However, successful patient outcomes ...
(Date:2/22/2017)... ... February 22, 2017 , ... South Bend’s Lunkerville, the ... once again feature Heroes On The Water (HOW), a non-profit organization dedicated to helping ... episode has series host ‘Mike D’ traveling to Lake Denmark, New Jersey, to fish ...
(Date:2/22/2017)... ... February 22, 2017 , ... A cylindrical “pipeline” used for ... to reach ones, according to the results of a clinical trial announced Wednesday. ... by Ricardo A. Hanel, MD, PhD, neurovascular surgeon with Baptist Health and Lyerly ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Corp. (NYSE: NVRO), a global medical device company that is ... today reported financial results for the three months and full ... & Highlights: Achieved revenue of $228.5 million ... reported, over the prior year U.S. revenue of ... prior year International revenue of $55.2 million ...
(Date:2/23/2017)... DUBLIN , Feb 23, 2017 Research ... Drugs Price Analysis and Strategies - 2016" report to their ... The ... provides drug pricing data and benchmarks in the global Oesophageal Cancer ... What are the key drugs marketed for Oesophageal ...
(Date:2/23/2017)... Regulus Therapeutics Inc . (Nasdaq: RGLS), ... innovative medicines targeting microRNAs, today announced it will release ... Thursday, March 2, 2017 after the market closes. ... on March 2, 2017 at 5:00 p.m. Eastern Time ... results and provide a general business update.  A live ...
Breaking Medicine Technology: