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Nobel Prize for Gene ‘Silencing

se’ RNAs paired and formed double stranded RNA that activated the RNA interference machinery and silenced the gene whose codes matched that of the injected RNA, resulting in the corresponding protein not being produced.

Fire and Mello have published their work in the February edition of Nature, 1998.These scientists, who have a PhD in biology, have simplified the understanding of the mechanism involved in the flow of genetic information besides clarifying several complicated experimental observations. The scientists have proposed that very little double stranded RNA is required to produce RNAi, which can spread from cell to cell and may be inherited.

RNA interference is an exciting research tool which has opened up new vistas in the field of gene technology and if used in clinical medicine, like cardiology and oncology, promotes exciting possibilities of a healthier tomorrow.

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