Navigation Links
No explanation on schizophrenia gene

Many scientists have drawn another blank in their search for a universally applicable genetic explanation for schizophrenia, binding the case for new approaches to researching the illness. A paper by Douglas F. Levison and colleagues report that despite earlier findings to the contrary, there is no close link between schizophrenia and genes on the long arm of chromosome 1.//

The researchers scoured the chromosome in more than 1,900 patients before reaching this conclusion."Schizophrenia is a complex psychiatric disorder," said co-author Dr Ann Pulver of Hopkins University. "It can't be explained by either a single altered gene or a single environmental cause. There are clearly genetic components, but they are likely to be varied and to interact in many ways with non-genetic factors."

She added that it was still possible that genes on chromosome 1 may contribute to schizophrenia, but they would influence only a small proportion of patients. Dr Philip Ward of the US National Institute of Schizophrenia and Allied Disorders said the findings underscored the need for a new method to "get a handle" on the condition.

"A previous study in Science showed that there was a highly significant link to this gene," he said. "However this multicentre study shows that this does not hold across a range of populations." Dr Ward said that since the discovery of the first genetic linkage with schizophrenia, which made the cover of Nature in 1995, genes on chromosomes 6, 8, 13, 22 had been linked to schizophrenia.

"The trouble has been to get the link to replicate across different populations," he said. According to Dr Ward, such findings raise questions about the approach that needs to be taken in research. Schizophrenia is known to involve genetic factors, since people who have relatives with the condition are more likely to have it, with 40 to 60 per cent concordance between identical twins.

"This tells us there's something geneti c but that it's not that simple — otherwise there'd be 100 per cent concordance in identical twins," said Dr Ward. "We need to stop hoping to luck upon a single genetic magic bullet and start thinking about what makes people susceptible." He said it was not schizophrenia itself that was inherited, but rather risk factors that predisposed people to the condition.

There were various clues that suggested these risk factors include problems with attention and reading, problems with fine motor co-ordination, obstetric complications, and older fathers, he said. The risk factor approach is already common in research on cancer, heart disease and diabetes, but schizophrenia researchers do not yet have the large database of evidence gathered by researchers in other fields.

One limitation had been that diagnosing schizophrenia is based on self-assessed symptoms, said Dr Ward. There's no lab test for hallucinations, you just rely on the patient saying they are having them." More holistic studies, looking at the brain structure, function, and genetics of closely-related people with schizophrenia would help the field go forward, he said. We need to go beyond diagnosis to find biophysical markers." This would enable more targeted, individualised, and evidence-based treatments.


'"/>




Related medicine news :

1. Research finds new explanations for dyslexia
2. Brain changes in schizophrenia to be analyzed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
Breaking Medicine Technology: