Navigation Links
No Evidence Older Women Generate New Eggs

It is highly unlikely that older women generate new eggs, report researchers at the University of South Florida in collaboration with a center in China.

The USF study, published in the issue of the journal Developmental Biology, counters the controversial findings of reproductive endocrinologist Jonathan Tilly, PhD, and his team of Harvard scientists. Tillys work, published in 2004 in Nature with a follow-up study a year later in Cell, challenged the biological dogma that mammals, including women, are born with a limited lifetime supply of eggs. Tilly reported the discovery of stem cells capable of migrating from bone marrow to mouse ovaries and generating new eggs there. The research fueled hopes that a new treatment such as bone marrow transplantation might one day help older women regain their fertility.

Since then, other papers have refuted Tillys surprising finding that mice can produce eggs throughout their lives. Now, David Keefe, MD, professor and chair of Obstetrics and Gynecology at USF, and colleague Lin Liu, who also holds a post at Sun Yat-Sen University in Guangzhou, China, say they can find no evidence to support his hypothesis that women may generate new eggs after birth.

The USF researchers searched for markers of stem cells or of meiotic cell division in ovarian cells biopsied from 12 women between the ages of 28 and 53.

Despite using the most sensitive methods available, we found no evidence of any egg stem cells in human ovaries, demonstrating that Dr. Tillys findings in mice do not apply to women, Dr. Keefe said. Dr. Tilly likely was seeing non-egg cells which resemble eggs. Another reason his findings do not apply to women could be because mice eggs are more resilient than womens eggs. The bottom line is that women should not expect stem cell therapy to treat egg infertility or menopause in the foreseeable future.

This is a very important finding by a distinguished group o f researchers and clinician-scientists at USF Health which affirms the traditional dogma of a finite period of fertility in women, said Abdul S. Rao, MD, MA, DPhil, senior associate vice president for USF Health and vice dean for research and graduate affairs at the College of Medicine.

The traditional view of fertility holds that women are born with all their eggs and they are released one by one (occasionally two) at each ovulation. At menopause, few to no mature eggs are believed to remain in the ovaries.


'"/>




Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Evidence supporting H.pylori eradication
3. Evidence against use of Beta blockers as first choice in the treatment of primary hypertension
4. Evidences that Better Health Care Facility is Offered By Public Hospitals.
5. First Conclusive Evidence Linking Oral Bacteria To Premature Babies
6. Study Provides Evidence That Obesity Leads To A More Aggressive Ovarian Cancer
7. No Clear Evidence for Ultra-Low Cholesterol Targets?
8. Lack of Evidence on Treatment for Narrowed Kidney Arteries
9. Some Evidence Shows Chinese Herbal Medicine Helps Angina Patients
10. Strong Evidence Suggests Incidence Of Mating Of Ancestors With Neanderthals
11. Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2016)... ... February 06, 2016 , ... ... 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , WHAT: ... world with an estimated 5000 perioperative nurses in attendance to study the ...
(Date:2/5/2016)... ... ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran the Miami Marathon on January ... year, he ran all 26.2 miles with a green 25-pound ShelterBox strapped to his ... This Sunday, while many are watching the Superbowl, Steven Tonkinson will strap on the ...
(Date:2/5/2016)... , ... February 05, 2016 , ... The event is ... Day Block Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 ... owner of Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this ...
(Date:2/5/2016)... Toronto, Ontario (PRWEB) , ... February 05, 2016 , ... ... the Scarborough General Hospital Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned ... the Scarborough Hospital. He successfully completed his first three-year term as chief and began ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each January, ... to access the treadmills. It’s a predictable trend. After the excesses of November and ... in shape by joining gyms, starting new walking or running routines, or signing up ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... -- The Senior Care Pharmacy Coalition (SCPC) today commended ... Jason Chaffetz (R-UT) and Ranking Member Elijah ... "Developments in the Prescription Drug Market," to examine ... abusive pharmacy benefit manager (PBM) pricing practices. ... Elijah Cummings (D-MD) are diligent, serious lawmakers committed ...
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... filed in the United States District Court for the District ... class (the "Class") consisting of all persons or entities who ... "Company") (NASDAQ: INSY ) from March 3, 2015 through ... and certain of its officers with violations of the Securities ...
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
Breaking Medicine Technology: