Navigation Links
No Carrier Necessary: This Drug Delivers Itself

ndra Pandey, Ph.D., Distinguished Professor of Biophysical Sciences at RPCI and a co-author on the paper.

"This is a case where the easiest formulation works the best," added Indrajit Roy, Ph.D., UB research assistant professor of chemistry and another co-author.

The researchers found that because HPPH is amphiphillic, i.e., partially soluble in water and oil, nanocrystals of it will self-assemble, that is, in solution the molecules aggregate, but not into such big clusters that they settle to the bottom.

"It's a controlled formation of a colloidally stable suspension of nanosized crystals," explained Tymish Ohulchanskyy, Ph.D., UB senior research scientist and a co-author.

The researchers originally were investigating nanocrystals as a delivery method for hydrophobic dyes in bioimaging applications, another promising use for nanocrystals that they continue to pursue.

Further in vivo studies with HPPH nanocrystals are being conducted by scientists at UB and RPCI, including Pandey and Allan R. Oseroff, M.D., Ph.D., chair of the department of dermatology at RPCI and in UB's School of Medicine and Biomedical Sciences.

The UB/RPCI team is exploring the use of the same technique for delivering other hydrophobic drugs, including those used in chemotherapy.

Additional co-authors on the paper are Koichi Baba, Ph.D., former postdoctoral research associate in the UB Department of Chemistry, and Yihui Chen, Ph.D., postdoctoral research associate at RPCI.

The nanocrystal research was supported by the National Institutes of Health, the John R. Oishei Foundation and UB's New York State Center of Excellence in Bioinformatics and Life Sciences with additional support from RPCI.

In related work, the UB researchers have achieved improved depth penetration of HPPH using two-photon photodynamic therapy, research that recently was published in the Journal of the American Chemical
'"/>




Page: 1 2 3

Related medicine news :

1. Alzheimer Gene Carriers Found To Have Memory Problems
2. Fruit Bats Act As Carriers of Ebola Virus
3. Financial Allowances Being Offered To Poor Vietnamese HIV Carriers
4. Coffee Reduces Risk of Breast Cancer in BRCA1 Mutation Carriers
5. A Carrier Protein Associates With Human Insulin Resistance
6. Genital Herpes - No Symptoms But A Potent Carrier
7. New Carrier Developed To Deliver Drugs to Gliomas
8. HIV Carriers Join Hands to Fight for their Rights
9. HIV Carriers Form an Association to Fight Social Stigma in Jharkhand
10. Carriers With Alzheimers High Risk Gene Type Age Normally Until the Disease Strikes
11. Woman Delivers Identical Quadruplets
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Carrier Necessary This Drug Delivers Itself

(Date:7/24/2014)... 2014 (HealthDay News) -- Even though its use is often ... Tylenol -- does not help treat lower back pain, according ... the drug was no more effective than a dummy pill ... pain. Besides showing no effect in easing discomfort, the ... sleep woes tied to back pain, nor did it improve ...
(Date:7/24/2014)... Attendances at emergency departments can be reduced by enabling ... visit their doctor,s surgery. This is just one of ... by researchers at the University of Bristol. , Called ... of systematic reviews, the report has been compiled by ... who looked at evidence from studies around the world. ...
(Date:7/24/2014)... have identified two previously undescribed radiological signs ... gastric bands. Adding widespread knowledge of the ... margin by more than 2.4 cm from ... air-fluid,level above the band on a frontal ... in diagnosing affected bariatric patients. These signs ...
(Date:7/24/2014)... Insecticides similar to nicotine, known as neonicotinoids, were ... to a new USGS study. This is the ... Midwestern United States and one of the first ... killing a broad range of insect pests, use ... last decade across the United States, particularly in ...
(Date:7/24/2014)... The National Resident Matching Program (NRMP) ... version of its smartphone app, The MATCH Program Rating ... in NRMP’s Main Residency Match® and Specialties Matching Service®. ... information during the interview process and develop program ratings ... lists. Rank order lists are used by the ...
Breaking Medicine News(10 mins):Health News:Acetaminophen May Not Help Against Back Pain, Study Contends 2Health News:Acetaminophen May Not Help Against Back Pain, Study Contends 3Health News:Seeing the same GP at every visit will reduce emergency department attendance 2Health News:Corn & soy insecticides similar to nicotine found widespread in Midwest rivers -- USGS news 2Health News:National Resident Matching Program® (NRMP®) Releases New, Enhanced Version of its Smartphone App 2Health News:National Resident Matching Program® (NRMP®) Releases New, Enhanced Version of its Smartphone App 3
... (NAFLD) have suboptimal levels of cardiovascular fitness, muscle strength, ... study. The findings appear in the April issue of ... Study of Liver Diseases (AASLD). The article is also ... , About one-in-four U.S. adults suffers from NAFLD, which ...
... Attributes encouraged in the trials process may improve overall ... -- Patients with heart attacks or other acute heart ... rates in hospitals that take part in clinical trials, ... than 174,000 patients with two types of heart conditions ...
... offering the best for its gifted students and staff members,Stanford ... machines, which are geared towards natural and ... of Solana Beach, Ca,YoNaturals Inc. was launched in August of ... have been committed, from the start, to providing,its customers with ...
... for Healthcare ... Professionals, HADDON ... malignant type of glioma. Healthcare professionals,face many challenges in the treatment ... in patients is less than,one year., Recent clinical trials have ...
... Mass., March 24 Andover,Medical, Inc. (OTC Bulletin Board: ... ("DME"), announced today that the,Company anticipates closing a $2.0 ... of the financing can be,found in the Company,s Form ... and,available at http://www.sec.gov ., On March 13, ...
... -- Heart damage due to blocked arteries remains the leading ... a Florida State University College of Medicine researcher is helping ... Blaber, a professor in the department of biomedical sciences, is ... shown to help the human body grow new blood vessels ...
Cached Medicine News:Health News:Study finds certain liver disease related to cardiovascular fitness 2Health News:Patients Do Better at Hospitals With Clinical Trials 2Health News:YoNaturals to Install Healthy Vending Machines at Stanford University 2Health News:Adult Glioblastoma: Strategies, Challenges, and Opportunities 2Health News:Andover Medical, Inc. Anticipates Closing $2.0 Million Private Financing 2Health News:Andover Medical, Inc. Anticipates Closing $2.0 Million Private Financing 3Health News:FSU researcher's 'mutant' proteins could lead to new treatment for heart disease 2
(Date:7/24/2014)...  Bruin Biometrics (BBI), a pioneer in biometric-sensor ... weeks of clinical briefings to over 200 pressure ... substantial concurrence on both the clinical validity of ... BBI,s SEM Scanner. "From our ... drawn from the European Wound Management Association (EWMA) ...
(Date:7/24/2014)... -- As part of its ongoing effort to help women pharmacists ... Ownership Boot Camp on July 26 as part of the ... D.C. The Boot Camp is designed ... own their own pharmacies.  Now in its third year, the ... women pharmacists who dream of owning a pharmacy.   ...
(Date:7/24/2014)... 2014 Lpath, Inc. (NASDAQ: ... therapeutics, reported interim results in a Phase 2a ... as a treatment for metastatic renal cell carcinoma ... one therapy involving a VEGF inhibitor (e.g., Sutent®/ ... inhibitor (e.g., Afinitor®/everolimus), with a maximum of three ...
Breaking Medicine Technology:Bruin Biometrics Secures Support of EU Scientific Community for its SEM Scanner Technology 2'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 2'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 3'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 4Lpath Reports Interim Data From Phase 2a Study for Anti-Cancer Drug, ASONEP 2Lpath Reports Interim Data From Phase 2a Study for Anti-Cancer Drug, ASONEP 3Lpath Reports Interim Data From Phase 2a Study for Anti-Cancer Drug, ASONEP 4
... SHANGHAI, Feb. 21, 2012 /PRNewswire-Asia/ -- ShangPharma Corporation (NYSE: ... leading China-based pharmaceutical and biotechnology research and development outsourcing ... Annual Health Care Conference, to be held in Boston, ... Xie, Vice President of Finance and Investor Relations of ...
... 2012  NewCrop LLC has selected Verizon Enterprise ... NewCrop,s new electronic system for prescribing controlled ... tailored digital identity solution, Verizon Universal ... submit electronic prescriptions for controlled substances via ...
Cached Medicine Technology:NewCrop Chooses Verizon to Help Provide Secure Electronic Prescriptions for Controlled Substances 2NewCrop Chooses Verizon to Help Provide Secure Electronic Prescriptions for Controlled Substances 3
Gently curved shaft with blunt angled tip is ideal for chopping the lens during anterior chamber phacoemulsification....
Nucleus divider with 1.25 mm tip and blade offset at a 60 degree angle is ideal for performing the "Phaco Chop" technique to be used in left hand. Round knurled handle....
Flat 7 mm wide hook. Flat serrated handle with polished finish. Overall length: 5.1 inches....
#2 10 mm hook. Flat serrated handle with polished finish. Overall length: 5.5 inches....
Medicine Products: