Navigation Links
Nicotine Dependence Gene Mapped to Chromosome 5

Genes that appear to increase the risk of nicotine dependence are likely to be found on several locations, including a region of chromosome 5//, according to a Yale School of Medicine study in Biological Psychiatry.

“These data add to the growing evidence for specific locations for genes that influence risk for nicotine dependence,” said Joel Gelernter, professor of psychiatry, genetics and neurobiology and lead author of the study. “The chromosome 5 linkage signal is our most remarkable result statistically.”

He said the finding is significant since any ability to predict nicotine dependence based on genes that influence risk could be useful and might help reduce the number of persons who begin smoking. The World Health Organization estimates that more than one billion people smoke, and the number is continuing to increase.

“Nicotine dependence, like alcohol, cocaine, and opioid dependence, is heritable,” Gelernter said. “It has been estimated that 60 percent or more of tobacco use is associated with heritable factors. We are using genetic linkage analysis can be used to identify genomic risk loci.”

The study population included 634 small nuclear families with multiple individuals affected by cocaine or opioid dependence. Most also provided nicotine dependence information. Study subjects came from two ethnic backgrounds — European-Americans and African-Americans.

The results showed there were a number of loci that appeared to contribute to risk and distinct differences between the two groups. The researchers also found one significant genome-wide linkage on chromosome 5 for the African-Americans and a strong linkage on chromosome 7 for European Americans.

“The overall pattern of results supports the interpretation that at least some genetic determinants of nicotine dependence overlap between different, differently ascertained populations,” Gelernter said, comparing his results to previously publi shed observations. “The chromosome 5 finding in African-Americans might be more specific to this sample, either because of the population or because of the way the sample was ascertained.”



Source: Yale Univesity
SRM
'"/>




Related medicine news :

1. Kick Smoking with Nicotine Drink
2. Teens Misusing Nicotine-Replacement Products
3. Nicotine Vaccine May Help Smokers To Quit Smoking
4. Nicotine patches instead of cigarettes – New Year resolutio
5. Nicotine Patches help to quit smoking
6. Reliable Help For Smokers From Nicotine Patches and Former Smokers
7. So Called Benefits of Nicotine
8. Research Finds That Nicotine Hastens The Growth Of Lung Cancer
9. Is Nicotine Lozenge A Safe Smoking Cessation Product?
10. Nicotine - New Role in Prevention of Parkinson’s Diseas
11. Chantix: Disenchanting Smokers from Nicotine
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... June 23, 2016 Any dentist who has made ... the current process. Many of them do not even offer ... difficulties and high laboratory costs involved. And those who ARE ... at such a high cost that the majority of today,s ... Dr. Parsa Zadeh , founder of Dental Evolutions Inc. ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
Breaking Medicine Technology: