Navigation Links
Nexavar Significantly Extends Survival of Liver Cancer Patients

CHICAGO, Bayer HealthCare Pharmaceuticals Inc. and Onyx Pharmaceuticals, Inc. today announced that Nexavar(R) (sorafenib) tablets significantly extended overall survival in patients with hepatocellular carcinoma (HCC), or primary liver cancer versus those taking placebo by 44%. Results were presented at the 43rd annual meeting of the American Society of Clinical Oncology (ASCO).

The international, Phase 3, placebo-controlled Sorafenib HCC Assessment Randomized Protocol (SHARP) Trial randomized and evaluated 602 liver cancer patients who had no prior systemic therapy at sites in the Americas, Europe, and Australia/New Zealand. The primary objective of the study was to compare overall survival in patients administered Nexavar versus those administered placebo.

Median overall survival was 10.7 months in Nexavar-treated patients compared to 7.9 months in those taking placebo."Because there are no therapies that significantly improve survival for the thousands of patients with liver cancer, these findings demonstrate the compelling study results of Nexavar as the new reference standard of care for the first-line treatment of HCC," said Dr. Josep M. Llovet, co-principal investigator and Professor of Research, Barcelona Clinic Liver Cancer (BCLC) Group, IDIBAPS, Liver Unit, Hospital Clinic Barcelona; Director of Research, HCC Program, Associate Professor of Medicine, Mount Sinai School of Medicine, New York.Bayer and Onyx halted the SHARP trial in February 2007 when an independent data monitoring committee determined in a pre-scheduled analysis that the overall survival endpoint had been met.

There were no significant differences in serious adverse event rates between the Nexavar and placebo-treated groups, with the most commonly observed serious adverse events in patients receiving Nexavar being diarrhea and hand-foot-skin reaction. Based on the strength of the data, the companies are now in the process of preparing applications
'"/>




Page: 1 2

Related medicine news :

1. Violence at Work Significantly Boosts Clinical Depression Risk
2. Computer-Driven System Reduces Patient Mechanical Ventilation Time Significantly
3. New Study: Pine Bark Significantly Reduces Endometriosis
4. STIs Significantly Increase Risk of Drug-resistant HIV Transmission
5. Masimo SET Pulse Oximetry Technology Significantly Reduce the Risk of ROP
6. Intensity of Rheumatoid Arthritis Significantly Reduced by Pregnancy
7. Irish Medicines Board Extends Paracetamol Recall To All Batches
8. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
9. Caloric Restriction in Non-obese People Extends Life Span
10. Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find
11. Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nexavar Significantly Extends Survival Liver Cancer Patients

(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... may put themselves at risk by talking on cell phones ... The researchers found that adults aged 59 to 81 took ... while talking on a mobile phone, and their heightened cautiousness ... adults on cell phones also were more likely to fail ...
... way to present risk statistics is key to helping ... found that health professionals and consumers may change their ... presented using alternative statistical formats. Risk statistics can ... lights. The different ways of expressing risk can prove ...
... , TUESDAY, March 15 (HealthDay News) -- Nearly 15 million ... of dementia, and the number is rising, according to a ... healthy may live as long as 20 or 25 years," ... the Alzheimer,s Association, which is publishing the report in the ...
... 2011 A UC Irvine infectious disease specialist will ... and Prevention research program to develop and test innovative ... Susan Huang medical director of epidemiology & infection ... Health Policy Research Institute affiliate and researchers from ...
... of a key biological receptor. The finding has the ... arthritis to respiratory disorders to wound healing, because it ... use in experimental drugs. The researchers are ... at The Scripps Research Institute and the University of ...
... experimental vaccine against the human norovirus the bug behind ... diarrhea and vomiting can generate a strong immune response ... Using a novel viral vector-based method to grow and ... designed to fight such infections as HIV and hepatitis C, ...
Cached Medicine News:Health News:Poorly presented risk statistics could misinform health decisions 2Health News:Almost 15 Million Americans Now Caring for Loved One With Alzheimer's 2Health News:Almost 15 Million Americans Now Caring for Loved One With Alzheimer's 3Health News:UCI jointly receives CDC grant to combat health care-associated staph infections 2Health News:Finding of long-sought drug target structure may expedite drug discovery 2Health News:New vaccine candidate shows strong potential to prevent highly contagious norovirus 2Health News:New vaccine candidate shows strong potential to prevent highly contagious norovirus 3Health News:New vaccine candidate shows strong potential to prevent highly contagious norovirus 4
(Date:1/15/2014)... DALLAS , Jan. 15, 2014 /PRNewswire-iReach/ -- ... research report to its store . ... from aging of population, consumption upgrade and policy ... industry has seen rapid development over the years, ... yuan in 2006 to 9.85 billion yuan in ...
(Date:1/15/2014)... AARP Foundation today announced it has established a ... the severe cold weather that has gripped much of ... helping those in need; so to support these emergency ... contributions up to $250,000, which could mean up to ... through AARP Foundation. (Logo: http://photos.prnewswire.com/prnh/20070209/NYF043LOGO ...
(Date:1/15/2014)... 2014 Shire plc (LSE: SHP, NASDAQ: ... Office of Fair Trading (OFT) approval condition to the announced ... Incorporated (NASDAQ: VPHM).   As a result of ... approval, and Shire expects to complete the tender offer on ... to the satisfaction of all of the remaining conditions to ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... onboard rail clamps mount ... tables and stretchers. The ... need for lifting. Easy ... stable surface combined with ...
The DHS Basic Set is available with either self-tapping or non-self-tapping screws. Either instrument set provides complete instrumentation in one graphic case for use with the Universal Implant Set,...
... is a versatile, fully powered orthopaedic and ... traction facilities, a powered centre break and ... versatile too. ,<br.,In fact the RX600 is ... it is for traction procedures. The RX600 ...
... orthopedic trauma procedures. Part of the ... trauma table top provides a complete, ... positioning and provides for skin or ... hip pinnings; femur, supine or lateral ...
Medicine Products: