( ells with the CF mutation which means ...)Newly Discovered Immune Defense May Be Impaired In CF Airways,Health

ells with the CF mutation, which means that hypothiocyanite is not produced. In other words, without thiocyanate the oxidative antibacterial system breaks down.

These results suggest that thiocyanate may not be present in the airway surface liquid of individuals with CF. Banfi and his colleagues intend to test that hypothesis by comparing thiocyanate levels in airway surface liquid from CF patients and from healthy individuals.

Thiocyanate is naturally present in body fluids like blood and saliva. Despite its name and its chemical relationship to cyanide, thiocyanate is not toxic. Hypothiocyanite is also harmless to human cells and tissues, but the UI team found that it is extremely efficient at killing bacteria including those most commonly associated with fatal lung infections in CF patients – Staphylococcus aureus and Pseudomonas aeruginosa.

"If we could reconstitute thiocyanate concentrations in the airway surface liquid, perhaps using a nebulizer, it might boost host defenses in CF patients and help prevent bacterial lung infections," Banfi said.

Source-Newswise
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