Navigation Links
New target for antidiabetic agents identified

U.S. researchers have identified a protein that could serve as a new target for drugs designed to treat type II diabetes. The protein, known as TRB3, is actually a homolog of a protein found in the fruit fly Drosophila tribbles, senior author Dr. Marc Montminy, from the Salk Institute for Biological Studies in La Jolla, California, and colleagues note.
The focus on TRB3 was the result of a search to identify proteins that modulate the activity of Akt, a main target of insulin that blocks hepatic glucose output when glucose is available from food. //Mice lacking the Akt gene demonstrate insulin resistance similar to that seen in humans with type II diabetes.

Dr. Montminy's team found that TRB3 acts as a negative modulator of Akt and that its expression is increased under fasting conditions. By binding to Akt, TRB3 prevents the enzyme from being activated by insulin, leading to increased glucose output from the liver.

Elevated hepatic levels of TRB3 RNA and protein were identified in diabetic mice compared with wild-type mice, the authors report. Hepatic overexpression of TRB3 was associated with hyperglycemia and glucose intolerance.

Based on these findings, the researchers suggest that TRB3 may be an "attractive drug target in the treatment of type II diabetes."
'"/>




Page: 1

Related medicine news :

1. Feeding channel created by malaria parasite - a new target for malaria treatments
2. Enzyme may be target for obesity drugs
3. Scios Inc. targets drug giants in arthritis war
4. Pharmaceutical companies are targeting patients
5. Ceramide can target and kill cancer cells
6. Multi targeted approach required for suicide prevention in adolescents
7. GPs discontented with 48-hour target
8. Maori diabetes project way off target
9. Microcapsules target cancer cells
10. Indian American Scientist at Work on Multi-targeted Drug
11. Special proteins to fight TB identified
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/9/2016)... ... December 09, 2016 , ... Groth Family Insurance, a ... Richland, is initiating a charity drive to support the family of Cindy Hendrickson, ... collision. , On October 29th of this year, Cindy Hendrickson swerved to ...
(Date:12/9/2016)... ... December 09, 2016 , ... Sober College, the ... the grand opening of the Sober College Robert Pfeifer Memorial Learning Center at ... 2-3, and was attended by an overwhelming amount of alumni, family, colleagues and ...
(Date:12/9/2016)... ... ... "I had a terrible time trying to get my grandson to use his ... had a more child-friendly design, then children would be more likely to look forward ... avoid the need to deliver medication via a nebulizer mask. The design will not ...
(Date:12/8/2016)... ... December 08, 2016 , ... Russ ... announced the first national #QuackGivesBack campaign which supported local breast cancer organizations during ... franchise-wide Quack Gives Back initiative, and we’re very pleased with the ...
(Date:12/8/2016)... ... December 08, 2016 , ... With the increasing demand for ... In Your Mouth?” (WIYM) campaign to inform dentists and patients about the safety issues ... implant and prosthetic market in the U.S. is projected to reach $6.4 billion in ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO) has been recognized by ... Workplaces National Standard. To learn more about Diplomat,s ... ... ... administered by WorkplaceDynamics, LLC, a research firm specializing in organizational health ...
(Date:12/8/2016)... Connecticut , 8 de dezembro de 2016  A Mederi Therapeutics ... terapia Stretta, um tratamento não cirúrgico para a doença do refluxo gastroesofágico (DRGE). ... ... Live Stretta procedure performed and ... of Endoscopy at Wuhan Union Hospital ...
(Date:12/8/2016)... Pa. , Dec. 8, 2016  A new ... reports that the use of opioid therapy to treat ... increase the likelihood of more harmful consequences, including death. ... , M.D., and Zankhana Mehta , M.D., authored ... research on chronic opioid therapy. The study was published ...
Breaking Medicine Technology: