Navigation Links
New target for antidiabetic agents identified

U.S. researchers have identified a protein that could serve as a new target for drugs designed to treat type II diabetes. The protein, known as TRB3, is actually a homolog of a protein found in the fruit fly Drosophila tribbles, senior author Dr. Marc Montminy, from the Salk Institute for Biological Studies in La Jolla, California, and colleagues note.
The focus on TRB3 was the result of a search to identify proteins that modulate the activity of Akt, a main target of insulin that blocks hepatic glucose output when glucose is available from food. //Mice lacking the Akt gene demonstrate insulin resistance similar to that seen in humans with type II diabetes.

Dr. Montminy's team found that TRB3 acts as a negative modulator of Akt and that its expression is increased under fasting conditions. By binding to Akt, TRB3 prevents the enzyme from being activated by insulin, leading to increased glucose output from the liver.

Elevated hepatic levels of TRB3 RNA and protein were identified in diabetic mice compared with wild-type mice, the authors report. Hepatic overexpression of TRB3 was associated with hyperglycemia and glucose intolerance.

Based on these findings, the researchers suggest that TRB3 may be an "attractive drug target in the treatment of type II diabetes."

Page: 1

Related medicine news :

1. Feeding channel created by malaria parasite - a new target for malaria treatments
2. Enzyme may be target for obesity drugs
3. Scios Inc. targets drug giants in arthritis war
4. Pharmaceutical companies are targeting patients
5. Ceramide can target and kill cancer cells
6. Multi targeted approach required for suicide prevention in adolescents
7. GPs discontented with 48-hour target
8. Maori diabetes project way off target
9. Microcapsules target cancer cells
10. Indian American Scientist at Work on Multi-targeted Drug
11. Special proteins to fight TB identified
Post Your Comments:

(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
(Date:6/23/2016)... VIEW, Calif. , June 23, 2016 ... a.m. CST on Thursday, July 7, 2016 , , , ... ) , , , , EXPERT PANELISTS:  , ... Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa ... The global pharmaceutical industry is witnessing an ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: