Navigation Links
New target for antidiabetic agents identified

U.S. researchers have identified a protein that could serve as a new target for drugs designed to treat type II diabetes. The protein, known as TRB3, is actually a homolog of a protein found in the fruit fly Drosophila tribbles, senior author Dr. Marc Montminy, from the Salk Institute for Biological Studies in La Jolla, California, and colleagues note.
The focus on TRB3 was the result of a search to identify proteins that modulate the activity of Akt, a main target of insulin that blocks hepatic glucose output when glucose is available from food. //Mice lacking the Akt gene demonstrate insulin resistance similar to that seen in humans with type II diabetes.

Dr. Montminy's team found that TRB3 acts as a negative modulator of Akt and that its expression is increased under fasting conditions. By binding to Akt, TRB3 prevents the enzyme from being activated by insulin, leading to increased glucose output from the liver.

Elevated hepatic levels of TRB3 RNA and protein were identified in diabetic mice compared with wild-type mice, the authors report. Hepatic overexpression of TRB3 was associated with hyperglycemia and glucose intolerance.

Based on these findings, the researchers suggest that TRB3 may be an "attractive drug target in the treatment of type II diabetes."
'"/>




Page: 1

Related medicine news :

1. Feeding channel created by malaria parasite - a new target for malaria treatments
2. Enzyme may be target for obesity drugs
3. Scios Inc. targets drug giants in arthritis war
4. Pharmaceutical companies are targeting patients
5. Ceramide can target and kill cancer cells
6. Multi targeted approach required for suicide prevention in adolescents
7. GPs discontented with 48-hour target
8. Maori diabetes project way off target
9. Microcapsules target cancer cells
10. Indian American Scientist at Work on Multi-targeted Drug
11. Special proteins to fight TB identified
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
Breaking Medicine Technology: