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New drug to treat Heart Attack and damaged tissue

If a blood vessel in blocked the related tissue experiences ischemia, a state of low oxygen supply that slowly kills the tissue. They are referred as Ichemia / Reperfusion (IR) injury occurs during heart attacks.

Understanding Ischemia / Reperfusion leads to the development of new drugs to save the damaged tissue and treat heart attack. During Ischemia / Reperfusion, Early growth response gene (Egr –1) level increases and acts like a common link between the pathways lead to tissue injury, such as the stimulation of chemokines, adhesion receptor molecules, procoagulants and permeability – related genes.

By deleting Egr-1 gene, the tissue injury level decreases and it enhances oxygen function and survival of the subject

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