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New compounds Help Sustain relief For Patients With Symptoms of Bowel Disorders

In the latest studies that was presented yesterday at Digestive Disease Week? 2006 (DDW) are finding that long-term therapy with new compounds can sustain relief for these patients with symptoms ranging// from constipation to inflammation. These studies are conducted to review the therapeutic benefits for irritable bowel syndrome (IBS) and Crohn’s disease. They claim that the symptoms of the bowel disorders like IBS and Crohn's disease may vary in function and their severity. DDW is the largest international meeting of physicians and researchers in the fields of Gastroentrologist, Hepatology, Endoscopy and gastrointestinal surgery.

A Dose-Ranging, Double-Blind, Placebo-Controlled Study of Lubiprostone in Subjects with Irritable Bowel Syndrome and Constipation (c-IBS) [Abstract 131] Irritable bowel syndrome (IBS) affects millions of people in America and is difficult to diagnose and treat effectively due to its variability of symptoms. Current therapies work on select patient populations, but are limited in efficacy and have significant side effects. In this study, researchers examine the use of a novel therapy as an effective and safe new option for IBS patients.

Lubiprostone, a novel type-2 chloride channel (ClC-2) activator, has shown positive results and good tolerability in previous trials of patients with chronic constipation. The therapy increases fluid secretion, which works to improve function in the gastrointestinal system. This study tested different doses of lubiprostone over 12 weeks in subjects with constipation-specific IBS (c-IBS), as defined by the Rome II Criteria, which outlines symptoms and applies parameters such as frequency and duration to more accurately diagnose IBS.

Approximately 50 patients were randomized to each of four treatment groups: placebo or 16, 32 or 48 μg lubiprostone daily. Patients were asked to keep a log of their progress, including dose, abdominal symptoms like bloating and discomfort
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