Navigation Links
New blood test to detect prostate cancer

A team of researchers at the John Hopkins Hospital in the US say that they have come up with a better alternative to the PSA to detect prostate cancer.//

The new test is called EPCA-2 (early prostate cancer antigen-2) and it works in a simple blood test.

Prostate cancer, the most common malignancy in men, is one of the more perplexing areas of medicine. Physicians are unsure how to find it and when to treat it.

Current standards of screening and testing for prostate cancer focus on the blood protein prostate-specific antigen (PSA) along with a digital rectal examination. Men who have more than 2.5 nanograms per milliliter of PSA are considered at risk for prostate cancer.

However, PSA testing often erroneously highlights noncancerous conditions (false positives) and can miss some cases of cancer (false negatives).

It is in such a backdrop the new test could prove to be a more useful option. EPCA-2 is a protein that is part of the 'nuclear matrix,' the scaffolding inside a cell's nucleus that helps it copy its genes.

A team led by Robert H. Getzenberg, professor of urology and director of research at the James Buchanan Brady Urological Institute at The Johns Hopkins University School of Medicine tried the new test on 30 men with PSA readings above 2.5 and in whom biopsies found no cancer.

All had normal EPCA-2 readings (below 30 ng per ml.). This suggested that the test may eliminate many of the 'false-positive' PSA results -- readings that are abnormal but apparently do not denote cancer.

On the other hand, the EPCA-2 test appears able to detect cancer even when the tumor is small. It identified 36 out of 40 men who had cancer confined to the prostate gland, and 39 out of 40 men in whom the tumor had spread. It also identified many men -- 14 out of 18 -- who had cancer but whose PSAs were normal.

Due to elevated PSA levels, approximately 1.6 million men undergo prostatic biopsies in the United States annually, and roughly 80 percent of these men have negative results, according to Getzenberg.

He says that of the entire population of men in the United States who have been tested for PSA, an estimated 25 million have elevated PSA levels and a biopsy of the prostate that did not reveal any prostate cancer. Conversely, roughly 15 percent of men with prostate cancer go undetected because their PSA levels are below the cutoff level.

In a study published in the April issue of the journal Urology, Getzenberg and his team note, 'A blood test based on EPCA-2 may greatly improve our ability to accurately detect prostate cancer early and minimize the number of false positives, therefore lowering the number of unnecessary biopsies.'

Getzenberg also points out, 'In addition, this is the first time we have a test that effectively distinguishes between men with cancer confined to the prostate and those whose disease has spread outside of the gland.'

'We hope this will minimize the number of unnecessary biopsies,' he adds.

EPCA-2 is the second prostate-cancer marker identified by Getzenberg and his team that has outperformed PSA. Last year, they discovered an unrelated, tissue-based test, EPCA-1, that also proved effective at identifying prostate cancer. The only commonality between these markers is that they were discovered using the same approach. Getzenberg says the efficacy of EPCA-1 as a test of biopsy samples is currently being evaluated.

Larger clinical trials for EPCA-2 are planned that could make this test available to the public in approximately 18 months.

Prostate cancer is diagnosed in about 230,000 American men each year, and about 30,000 die of it. The death rate is 2.5 times higher among blacks than among whites.


GPL/V
'"/>




Related medicine news :

1. Infant receives first bloodless liver transplant
2. Spouses and other partners lower blood pressure says new research
3. H2O - a cure for low blood pressure
4. Uncontrolled blood pressure
5. Nitric oxide involved in high blood pressure
6. Recouping blood flow after a stroke
7. Way to monitor blood pressure
8. Drugs disrupt formation of blood vessels
9. Gene therapy - Aim to improve blood flow
10. New Drug ALT-711 decreases blood vessel stiffness
11. Aggressive blood pressure treatment needed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... N.J. (PRWEB) , ... October 13, 2017 , ... The ... Holly Day Market. Featuring a collection of specialty vendors and unique items from across ... personalized and quality-focused health and wellness services offered by the VNA. The boutique ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans Bioscience ... the use of wearable and home sensors for real-time ... Early Signal Foundation, a nonprofit organization focused on disruptive ... provide an affordable analytical system to record and integrate ... ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
Breaking Medicine Technology: