( According the study done by Roseborough...)New Way To Combat Spinal Cord Injury during Aortic Surgery,Health

According the study done by Roseborough et al., mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. //Spinal injuries are the common problems that occur during aortic surgery but surgery done to repair aortic aneurysms often results in neurological deficits. But the works of Roseborough et al has given new hopes to treat spinal cord injuries.

The results of his work are published in the journal of the American Journal of Pathology. Weakness and/or paralysis of lower limbs following thoracoabdominal aortic aneurysm surgery result mainly from loss of blood flow (ischemia) to the spinal cord, a consequence of clamping the aorta to prevent bleeding. While severe deficits can be controlled through reduced ischemia time, the mere act of reintroducing blood and oxygen (reperfusion) also causes cellular damage.

Ischemia-reperfusion injury exerts its effects on the spinal cord via release of reactive oxygen species, damage to cellular components such as mitochondria, and initiation of cell death. Dr. Chiming Wei and colleagues from the Department of Surgery at The Johns Hopkins University School of Medicine have specifically targeted ischemia-reperfusion-mediated mitochondrial damage, which directly contributes to cell death. They hypothesized that they could prevent spinal cord injury if they blocked mitochondrial damage with the drug diazoxide, which prevents mitochondrial failure and subsequent cell death.

Using a rabbit model of ischemia-reperfusion injury, Dr. Wei's team demonstrated that administration of diazoxide prevented hind limb paralysis. All animals treated with diazoxide prior to clamping of the aorta retained mobility in their hind limbs, though hopping was impaired, in sharp contrast to complete hind limb paralysis in all untreated animals. Further, mitochondria from spinal cords of diazoxide-treated rabbits displayed considerably less structural damage compared to tho
'"/>




Page: 1 2
Related medicine news :

1. Virus Combats Brain Tumour
2. Combating insomnia with warm feet
3. Oral Medication Effective In Combating Eye Infection
4. Vitamin- B 12 Supplements Found To Be Effective In Combating Depression
5. Chocolate To Combat Cancer: So Indulge!
6. Increase Cereal Fibre To Combat Atherosclerosis
7. China To Distribute Free Condoms To Combat AIDS/HIV
8. Novel Strategy To Combat Alzheimer’s Disease
9. Mizoram Prepares To Combat Bird Flu
10. A Joint Venture by Golfers And Military Forces To Combat AIDS
11. Supercomputer Grid Enlists PCs To Combat AIDS