Navigation Links
New Vaccine for CMV Infection

A strategy for developing a human vaccine to prevent against Human Cytomegalovirus (hCMV) infection and disease was developed by researchers at the University of California , San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences.

CMV, a type of herpes virus, is the leading viral cause of birth defects and a serious problem in patients with compromised immune systems. The bodys natural immunity doesnt protect against infection by the virus, estimated to be present in 50 to 75 percent of all adults.

Until now, scientists havent been able to develop a vaccine to protect against CMV, said Deborah H. Spector, Ph.D., UCSD Professor of Cellular and Molecular Medicine and faculty member of the Skaggs School of Pharmacy and Pharmaceutical Sciences. Using a two-pronged approach, we successfully created and tested a vaccine in a mouse model with CMV that shows enormous promise for re-directing the bodys immune system, enabling it to fight the virus.

The mouse vaccine generates an immune response that protects against both infection and development of disease when the virus is present by completely disarming the viruss ability to replicate and establish a persistent infection.

Our approach generates an immune response that is different from the normal response to the virus, and we hope to have found an Achilles heel in the defenses that the virus uses to evade the immune system, said Spector.

The virus has evolved to persist in the host by evading the immune responses either by hiding or by misdirecting the hosts immune responses. We found a way to teach the host immune system to not be tricked by the virus. She added that the next step is to apply this strategy to create a vaccine for use in humans.

CMV is a virus that, while carried by the majority of adults in the United States, can remain dormant for years, if not the lifetime, of a healthy individual. However, two percent of all children are born with the virus passed on by the mother in utero, and 15 percent of those children will show symptoms such as hearing loss, mental retardation, motor or learning disabilities.

Because the hosts natural immune system can protect from the disease but cant rid the body of the virus, people remain infected and can become re-infected or infect others through saliva.

Children in day care settings, for example, or adults who are sexually active, can pass along the virus, explained Spector. It becomes a serious problem in developing infants during the pregnancy or in those whose immune system is compromised, such as AIDS or transplant patients.

When a persistent virus such as CMV infects an individual, it disarms the host immune system in two ways by hiding or masking the proteins that would normally provoke an immune response, or by fooling the immune system into mounting a response that doesnt work to eradicate the virus. We needed a way to make the host defense system sit up and take notice, said Christopher S. Morello, Ph.D., first author of the study.

To do this, the researchers devised a vaccine with a one-two punch that combines a DNA immunization that targets T-cells to essential genes required for CMV replication, with a killed virus that prompts the bodys B-cells to generate an antibody response.

The vaccine contains the DNA of two essential genes that are essential for replication of the virus. These genes which are also found in other herpes viruses such as chicken pox or herpes simplex have the same or very similar sequence, structure and function whether in human or mouse viruses, and present a novel target for the hosts T-cells to muster forces and attack the virus.

Secondly, the vaccine also contains a boost from an inactivated virus, which generates an antibody response. Neither approach alone would give complete protection.In mice, the vaccine not only fought the disease, b ut prevented the infection from being established in the first place, Morello said.

Researchers at UCSD hope to begin pre-clinical work on development of a human vaccine. If successful, an FDA-approved, commercially licensed hCMV vaccine could be administered to specific at-risk populations, such as females prior to child-bearing years, day care providers, organ transplant recipients, or as part of regular childhood immunizations.

This approach may also be valid for a number of diseases associated with persistent or latent infections, including all types of herpes-associated diseases, AIDS, or hepatitis, said Spector. These viruses persist because immune responses generated by the viral infection are not able to eradicate the virus.


Related medicine news :

1. Vaccine to quit smoking?
2. First Vaccine Designed for Africa Cleared for Testing in Humans
3. Vaccine for Alzheimer’s diseas
4. Health Officials Recommend Flu Vaccine
5. Smallpox Vaccine May Help Fight Cervical Cancer
6. Panacea Biotech To Market Anthrax Vaccine
7. New Prostate Cancer Vaccine Shows Promise
8. Drug Firm Offers to Donate Smallpox Vaccine
9. Vaccine guards against shingles
10. Vaccine for septic conditions
11. A new Vaccine for Pneumonia
Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important to ... Fortunately, an inventor from Austin, Texas, has identified a solution. , She developed a ... or restricted lighting. As such, it eliminates the need to turn on a light ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today announced that it will release third-quarter 2017 ... 26, 2017, and will follow with a conference call ... a.m. Eastern Time. To participate on the call, please ... is 94093362. A ...
(Date:10/11/2017)...  Caris Life Sciences ® , a leading innovator ... precision medicine, today announced that St. Jude Medical Center,s ... (POA) as its 17 th member. Through participation ... Cancer Institute will help develop standards of care and ... making cancer treatment more precise and effective. ...
(Date:10/11/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an update ... Puerto Rico , where the company manufactures ... Following a comprehensive onsite assessment, the ... temporary loss of power and minimal water damage due ... have resumed, and the company expects to return to ...
Breaking Medicine Technology: