Navigation Links
New Tumor Markers for Pancreatic Cancer

Pancreatic cancer(PC) has the poorest prognosis of all cancers: the survival rate after five years with the disease is less than 5% and on average , patients who have been diagnosed with it do not live longer than six months.

The modus operandi of cells is well known: the genes (DNA) are the masterminds of the system and their role is to give orders. Those orders are transmitted in the form of messages (RNA), which ultimately become molecules that do the work (proteins). Since all cells have similar genes, they are all able to give the same range of orders.

However, depending on their role and the signs and information they receive from their surroundings, each cell type sends only specific messages at any one time. While in normal cells this process is carried out following an organized pattern, this pattern of messages changes completely in cancer cells. When pancreatic cells transform into cancer cells, they abandon their usual functions and start sending abnormal messages, which encourage them to quickly divide and invade nearby tissues.

The aim of this PhD was to intercept messages sent by cancerous pancreatic cells and compare them with those sent by healthy pancreatic cells. This comparison would indicate which orders (messages) are the ones that make the cancer grow and invade and which weapons (proteins) it uses to do so.

In order to carry out this work we used microarrays or DNA-chips, a technique used for multiple analyses. It allows the detection and quantification of messages sent by thousands of genes. We analysed biopsies of PC as well as samples of healthy pancreas. The RNA (thousands of messages sent by cells) from each sample was extracted and fluorescently labelled.

The RNA has the ability to join complementary DNA. The organized DNA fragments contained on a microarray can detect all possible messages sent by the nearly 30,000 genes that exist in the human genome. When RNA is expose d to the microarray, each message binds to its matching DNA, producing fluorescent signal.

These findings reveal some of the orders that allow pancreatic tumours to grow quickly, feed and invade other tissues. Additionally, these messages and the proteins for which they code are potential diagnostic markers and targets to tackle when developing new anti-cancer treatments.

Finally, we generated antibodies that detect the proteins coded by some of the messages. Using a microscope and colour-labelled antibodies, we managed to dye PC cells and to distinguish them from cells of a healthy pancreas or a pancreas with chronic pancreatitis. These results indicate the usefulness of this marker and establish the basis for the development of a differential diagnostic system for PC.


'"/>




Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Radiofrequency Energy Cooks Tumors Without Surgery
3. New Liver Tumor Treatment
4. Latest Tumor Classification More Informative
5. New Technique For Benign Breast Tumors
6. Another Treatment Option for Benign Tumors
7. Understanding The Origin Of Tumors
8. Outpatient Treatment Possible For Patients with Uterine Fibroid Tumors
9. Stem Cells, Tumor Cells Share Similar Properties: Scope For Treatment and Prevention?
10. Lipoma Arborescens: A Rare Tumor Of The Knee
11. Researchers Develop Mouse Model Of Brain Tumor
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2016)... ... February 13, 2016 , ... ... Society (INS) states that vein visualization technology should be used to ensure patient ... around the world, the INS Standards mandate the use of vein visualization technology ...
(Date:2/13/2016)... ... 13, 2016 , ... When an Au Pair comes all the way around the ... in for and they are often worried things won’t go well. More often than not, ... year’s Au Pair of the Year winner’s all commented how their Au Pairs have become ...
(Date:2/13/2016)... ... February 13, 2016 , ... DDi ... Management Solution Providers list for its expertise in eClinical Solutions. DDi has built ... serve the technology needs of global clients. DDi provides smarter technology for Clinical ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Mystic Buddha Publishing ... in Blue SKies Buddha, the biography of Rama - Dr. Frederick Lenz. ... story, the love of a Buddhist teacher for teaching and helping others. Valentine’s ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the advanced skills needed to introduce ... from U.S. universities who will draw from Siemens’ deep knowledge of product ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Maharashtra, February 12, 2016 ... Market research report titled Chronic Inflammation Global Clinical ... a snapshot of the global clinical trials landscape ... clinical trials by Region, Country (G7 & E7), ... point status and reviews top companies involved and ...
(Date:2/11/2016)... Feb. 11, 2016 Stem cells are primitive ... by self-renewal and the capacity to differentiate into mature ... discovery, as the first mouse embryonic stem cells were ... until 1995 that the first culturing of embryonic stem ... were not produced until 2006 As a result of ...
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016  Kindred ... focused on saving and improving the lives of pets, ... Technical Section of the New Animal Drug Application (NADA) ... the pivotal field study (KB0120) of Zimeta for the ... by the Company. --> ...
Breaking Medicine Technology: