Navigation Links
New Tumor Markers for Pancreatic Cancer

Pancreatic cancer(PC) has the poorest prognosis of all cancers: the survival rate after five years with the disease is less than 5% and on average , patients who have been diagnosed with it do not live longer than six months.

The modus operandi of cells is well known: the genes (DNA) are the masterminds of the system and their role is to give orders. Those orders are transmitted in the form of messages (RNA), which ultimately become molecules that do the work (proteins). Since all cells have similar genes, they are all able to give the same range of orders.

However, depending on their role and the signs and information they receive from their surroundings, each cell type sends only specific messages at any one time. While in normal cells this process is carried out following an organized pattern, this pattern of messages changes completely in cancer cells. When pancreatic cells transform into cancer cells, they abandon their usual functions and start sending abnormal messages, which encourage them to quickly divide and invade nearby tissues.

The aim of this PhD was to intercept messages sent by cancerous pancreatic cells and compare them with those sent by healthy pancreatic cells. This comparison would indicate which orders (messages) are the ones that make the cancer grow and invade and which weapons (proteins) it uses to do so.

In order to carry out this work we used microarrays or DNA-chips, a technique used for multiple analyses. It allows the detection and quantification of messages sent by thousands of genes. We analysed biopsies of PC as well as samples of healthy pancreas. The RNA (thousands of messages sent by cells) from each sample was extracted and fluorescently labelled.

The RNA has the ability to join complementary DNA. The organized DNA fragments contained on a microarray can detect all possible messages sent by the nearly 30,000 genes that exist in the human genome. When RNA is expose d to the microarray, each message binds to its matching DNA, producing fluorescent signal.

These findings reveal some of the orders that allow pancreatic tumours to grow quickly, feed and invade other tissues. Additionally, these messages and the proteins for which they code are potential diagnostic markers and targets to tackle when developing new anti-cancer treatments.

Finally, we generated antibodies that detect the proteins coded by some of the messages. Using a microscope and colour-labelled antibodies, we managed to dye PC cells and to distinguish them from cells of a healthy pancreas or a pancreas with chronic pancreatitis. These results indicate the usefulness of this marker and establish the basis for the development of a differential diagnostic system for PC.


'"/>




Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Radiofrequency Energy Cooks Tumors Without Surgery
3. New Liver Tumor Treatment
4. Latest Tumor Classification More Informative
5. New Technique For Benign Breast Tumors
6. Another Treatment Option for Benign Tumors
7. Understanding The Origin Of Tumors
8. Outpatient Treatment Possible For Patients with Uterine Fibroid Tumors
9. Stem Cells, Tumor Cells Share Similar Properties: Scope For Treatment and Prevention?
10. Lipoma Arborescens: A Rare Tumor Of The Knee
11. Researchers Develop Mouse Model Of Brain Tumor
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... LaserShip, a ... water to the Food Bank of Eastern Michigan last Friday in order to aid ... footprint into the Midwest to include a facility located in Clio, only 15 miles ...
(Date:2/10/2016)... Walton Beach, Florida (PRWEB) , ... February 10, ... ... the innovative weather-forecasting company is unveiling its revolutionary new 2.0 version at the ... platform, MetLoop has “put the power of the world's most advanced weather technology ...
(Date:2/10/2016)... ... February 10, 2016 , ... Intermedix announced on ... Medicine , an emergency medicine professional association, to support the organization's newly established ... American Academy of Emergency Medicine, or AAEM, seeks to empower emergency physicians to ...
(Date:2/10/2016)... ... , ... Emergency rooms provide emergency care to stabilize critical health issues, but ... dental emergencies at risk of losing a tooth or their smiles. Dr. Marine Martirosyan, ... dental emergencies include:, , Avulsed or knocked-out teeth , ...
(Date:2/10/2016)... ... February 10, 2016 , ... Dr. Jessica Barron, of Barron Family ... new dental patients and families in the North Metro Denver area. The new dental ... to cosmetic dentistry, and all in the most relaxing environment. , While some dental ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Mylan N.V. (NASDAQ, TASE: MYL) today announced its financial ... --> --> Financial ... $9.45 billion, up 28% on a constant currency basis ... billion. Excluding the impact of the acquisition of Abbott ... (the "EPD Business"), full year adjusted total revenues increased ...
(Date:2/10/2016)... February 10, 2016 A new report from business intelligence ... states that the Alzheimer,s disease market will more than double from just under ... Compound Annual Growth Rate (CAGR) of 11%. Canada , ... , Spain , the UK, and Japan ... forecast period. --> Canada , France ...
(Date:2/10/2016)... SAN DIEGO , Feb. 10, 2016 ... viral gene therapy manufacturing, and Renova™ Therapeutics, a biopharmaceutical ... and other chronic diseases, have entered into a Manufacturing ... produce cGMP-grade RT-100 (Ad5.hAC6) Drug Product for use in ... --> This relationship will leverage Lonza,s ...
Breaking Medicine Technology: