Navigation Links
New Treatment Offers Hope for Systemic Sclerosis

Systemic sclerosis (SSc) is a chronic autoimmune disorder marked by early skin lesions and the progressive tissue fibrosis.// More than skin deep, this thickening and hardening of connective tissue affects the blood capillaries, the gastrointestinal tract, the lungs, and the heart. In SSc patients, fibrosis frequently leads to organ dysfunction, serious illness, and death. Researchers have yet to determine the underlying cause of this disfiguring, debilitating condition or find an effective anti-fibrotic remedy.

Studies of SSc suggest the central role of two cytokines, transforming growth factor ? (TGF?) and platelet-derived growth factor (PDGF), in the development of fibrosis through stimulating the synthesis of extracellular matrix (ECM) proteins. On the strength of these findings, researchers at the University of Erlangen-Nuremberg, Germany and University Hospital Zurich, Switzerland, set out to test the therapeutic potential for SSc patients of a small growth factor inhibiting molecule widely used in the treatment of leukemia.

Through skin biopsies, researchers obtained fibroblast cultures from the lesions of five patients with SSc, and six healthy sex- and age-matched controls. All the specimens were stimulated with TGF? and PDGF and incubated with the inhibitory molecule, imatinib mesylate. Then, applying real-time polymerase chain reaction and various assays, researchers analyzed and compared the expression of EMC proteins in SSc and normal skin fibroblasts. In addition, they assessed the anti-fibrotic effects of imatinib mesylate on laboratory mice with bleomycin-induced dermal fibrosis compared with non-diseased controls.

On the experimental fibroblast cultures from SSc patients, imatinib mesylate strongly reduced the synthesis of EMC proteins, the number of myofibroblasts, and the thickness of skin, almost back to levels observed in the healthy control groups. Similarly, imatinib mesylate effectively suppressed the deve
'"/>




Page: 1 2

Related medicine news :

1. Advances in Treatment of Cataracts
2. Recommendations for Treatment of Blood Pressue
3. Treatment for Menieres disease
4. Treatment for pre-menstrual syndrome is ineffective
5. Better Treatment for obesity
6. Gene Treatment for Heart Disease
7. More People Seeking Treatment for Depression
8. Focused Treatment For Childhood Cancer
9. Inadequate Drug Treatment For Youth
10. FDA Approves New surgery Treatment for Farsightedness
11. Treatment of antibiotics ineffectual in bronchitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Treatment Offers Hope for Systemic Sclerosis

(Date:2/28/2015)... (PRWEB) March 01, 2015 Heart diseases ... that 10 percent of urban adult population and 5 ... of heart diseases and 20-30 percent of them require ... heart ailments and coronary vascular diseases (CVD). , A ... a new market research report titled “Indian Coronary Stent ...
(Date:2/28/2015)... 28, 2015 The Classic Denture ... a new special. Throughout all of March patients ... , This service can help overall mouth ... pain. Patients may notice certain symptoms that suggest the ... These symptoms include: , 1.    Pain, clicking, and popping in ...
(Date:2/28/2015)... February 28, 2015 A study out ... new gene therapy procedure for the treatment of a ... patients. Authored by Dr. Robert MacLaren, professor ... in the Lancet Medical Journal on January 16, 2014 ... a rare genetic disorder that mostly affects men and ...
(Date:2/28/2015)... Dr. Perry Patel , a dentist ... announced a special offer for the Zoom!® Chairside ... new and established patients at his Pismo Beach dentist office. To ... smile, Dr. Patel and his staff are offering Zoom! ... the regular price of $450. , Zoom! whitening is ...
(Date:2/28/2015)... York, NY (PRWEB) February 28, 2015 On ... Phishing Kits Make It Easy For Scammers To Steal Your ... anyone can get their hands on a DIY phishing kit, ... But it also touched on another important point about how ... these kits are often implemented, “like compromising legitimate content management ...
Breaking Medicine News(10 mins):Health News:India Coronary Stent Market 2019 Forecasts Analysis in New Research Report Available at MarketReportsOnline.com 2Health News:India Coronary Stent Market 2019 Forecasts Analysis in New Research Report Available at MarketReportsOnline.com 3Health News:Classic Denture Center in Portland Oregon is Offering March Discount 2Health News:New Gene Therapy Procedure Could Hold Key to Preventing Blindness for Certain Patients 2Health News:Pismo Beach Dentist Announces Special for Zoom! Teeth Whitening 2Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 2Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 3Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 4
... In keeping with the American Institute of Ultrasound ... safe and effective use of ultrasound in medicine ... AIUM recognizes the American College of Emergency Physicians ... the qualifications for performing ultrasound in the emergency ...
... , THURSDAY, Dec. 8 (HealthDay News) -- The brains of ... of streets and places of interest over several years, a ... learning can lead to changes in the adult brain, which ... after brain injury, according to the U.K. researchers. The ...
... are reporting they are burned out and dissatisfied with their ... Nursing,s Center for Health Outcomes and Policy Research in a ... 20 to 60 percent of nurses reported symptoms of burnout ... for Quality in Health Care , which collected data from ...
... Copenhagen have explored the active principles of a Danish mushroom ... particularly toxic towards cancer cells. The goal is to synthesise ... in future drug development. Asia has a long ... products. Many substances found in fungi are today registered as ...
... quarter century in Australia, cancer incidence rates have increased while ... the findings of a recent study published early online in ... with any other disease group, cancer has the greatest overall ... cancer and one in five dying from it before the ...
... -- A stressful early pregnancy could lower a woman,s odds ... delivery, a new study suggests. The findings from an ... affected pregnant women in Chile suggest that pregnancy can be ... that often accompany or cause stress, such as poverty, the ...
Cached Medicine News:Health News:AIUM officially recognizes ACEP Emergency Ultrasound Guidelines 2Health News:Taxi Drivers Show How Learning Changes Adult Brain 2Health News:To keep nurses, improve their work environments 2Health News:Danish mushroom inspires cancer researchers 2Health News:Danish mushroom inspires cancer researchers 3Health News:Study sheds light on cancer burden in Australia 2Health News:Stress Early in Pregnancy Linked to Fewer Baby Boys 2
(Date:2/26/2015)... February 27, 2015 RnRMarketResearch.com ... market research report to its store. This report ... therapeutic pipeline. The report "Corneal Ulcers - Pipeline ... therapeutic development for Corneal Ulcers. Corneal Ulcers are ... bacterial infections, viral infections & fungal infections. The ...
(Date:2/26/2015)... , Feb. 26, 2015  AbbVie (NYSE: ... abstracts of studies in its neuroscience and oncology ... the 67 th American Academy of Neurology ... , from April 18-25. The accepted abstracts feature ... in addition to investigational treatments in AbbVie,s pipeline. ...
(Date:2/26/2015)... VIEW, Calif. , Feb. 26, 2015  IRIDEX Corporation ... release its fourth quarter and full year 2014 financial results ...   In conjunction with the release, the Company will host ... p.m. Eastern Time on Thursday, March 5, 2015 ... business developments. Interested parties may access the live ...
Breaking Medicine Technology:Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 2AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 3AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 4AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 5AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 6AbbVie's Ongoing Research in Neuroscience and Oncology will be Featured at the 2015 American Academy of Neurology Annual Meeting 7IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2
... Nationally-acclaimed researcher and award-winning author Dr. Cynthia C. Chernecky ... on Cancer Nursing Research that silver treated IV connectors ... to prevent. After testing antimicrobial effectiveness ... coated or silver impregnated fluid pathway components, Dr. Chernecky, ...
... 2011 Today, Smith & Nephew, Inc. (LSE: SN; ... with famed sports icon and humanitarian Billie Jean King ... with a Smith & Nephew product. One year ago, ... Nephew,s LEGION knee with the company,s exclusive VERILAST™ Technology, ...
Cached Medicine Technology:Instead of Preventing Infections, Silver Coated Needleless IV Connectors May Actually Cause Them, a Nationally-Recognized Expert Tells National Conference on Cancer Nursing Research 2Sports Icon Billie Jean King Gets Back in the Game with Help from New Knees 2Sports Icon Billie Jean King Gets Back in the Game with Help from New Knees 3Sports Icon Billie Jean King Gets Back in the Game with Help from New Knees 4
Fine pointed grooved jaws with smooth curve from tip to finger grip style handle. Dull finish....
Inner jaw space 2.0 mm - 45 degree tip angulation. 20 gauge (.89 mm) diameter shaft and stationary distal jaw. Lightweight squeeze handle with dull finish. Jaws 1.5 mm serrated....
Straight shafts with 5.5 mm tying platform and 45 degree 0.3 mm teeth. Wide serrated handle with polished finish....
Straight shafts with 1 x 2 teeth. Flat handle with polished finish....
Medicine Products: