Navigation Links
New Transgenic Mushrooms Raise Hope for Mass Production of Human Drugs

Penn State and Agariger, Inc. have patented the technology of making new transgenic mushrooms, which have increased hope of using mushrooms for the mass production of commercially valuable proteins or useful human drugs.

The technology was introduced by a team of researchers including Charles Peter Romaine and Xi Chen at Penn State.

As part of the study, scientists developed a technique to genetically modify Agaricus bisporus, which is the predominant edible species worldwide by attaching a gene that confers resistance to hygromycin, an antibiotic, to circular pieces of bacterial DNA called plasmids, which have the ability to multiply within a bacterium known as Agrobacterium.

The hygromycin resistance gene was a marker gene to help sort out the transgenic mushroom cells from the non-transgenic cells.

Scientists then cut small pieces off the mushroom's gill tissue and added it to a flask containing the altered bacterium. Over the course of several days, as the bacterium went through its lifecycle, it transferred a portion of its plasmid into the mushroom cell, and integrated the introduced gene into the chromosome of the mushroom.

The researchers then exposed the mushroom cells to hygromycin. The antibiotic killed all the normal cells, separating out those that had been genetically altered for resistance.

The study demonstrated that if a second gene, insulin for example, were to be patched in the plasmid, that gene would be expressed as well.

"There is a high probability that if the mushroom cell has the hygromycin resistance gene, it will also have the partner gene," Romaine said.

Researchers noted that the process of producing biopharmaceuticals is potentially faster and cheaper with mushrooms than conventional technologies.

"With mushrooms, we can use commercial technology to convert the vegetative tissue from mushroom strains stored in t
'"/>




Page: 1 2

Related medicine news :

1. Goat’s Milk One of the First Transgenic Food That Benefits Human
2. Mushrooms can help fight chronic disease
3. Novel Vitamin D source in Mushrooms!
4. Mushrooms are Rich Source of Antioxidants
5. Four of Family Died After Consuming Poisonous Mushrooms
6. Magic Mushrooms Treat Obsessive Compulsion Disorder
7. Heavy Drinking Raises Risk of Liver Cancer
8. Swimming in Chlorinated Pools Raises Asthma Risk
9. New Treatment To Raise Good Cholesterol
10. Common Infections Found To Raise An Individuals Risk Of Having A Heart Attack Or Stroke
11. Polycystic Ovary In Women May Raise Liver Disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Transgenic Mushrooms Raise Hope for Mass Production Human Drugs

(Date:10/25/2014)... 26, 2014 Top 10 Best SEO ... the world. The site has recently compared many hosting ... HostMonster are among the most reliable Linux web hosting ... Top 10 Best SEO Hosting says, “The hosting suppliers ... companies who outperform their competitors on hosting features, uptime ...
(Date:10/25/2014)... The global HCIT outsourcing market is ... reach $50.4 billion by 2018 from $35 billion in ... pharmaceutical industry are driving the HCIT outsourcing market. These ... focus on core business, reduce operational and maintenance costs, ... reducing hiring and training costs), share risk, and quickly ...
(Date:10/25/2014)... The Wehrman Collaborative, LLC ... for disabled users by disabled users, has granted ... Mackin Educational Resources of Burnsville, Minnesota, for their ... to the Minnesota Alliance for Patient Safety of ... website. Both organizations have met WeCo’s ...
(Date:10/25/2014)... NC (PRWEB) October 25, 2014 Mesothelioma ... who continued to receive pemetrexed (Alimta), after his combination ... read the full story , just posted on the ... from Uji Tokushukai Medical Center in Japan suggests that ... mesothelioma patients who cannot tolerate higher doses ...
(Date:10/25/2014)... 2014 (HealthDay News) -- Researchers who discovered antibiotics ... are cause for concern. The use of ... for human consumption contribute to the development of ... background information from the study. Each year ... 2 million people and kill about 23,000, according ...
Breaking Medicine News(10 mins):Health News:Top 10 Best SEO Hosting Announces That GreenGeeks.com And HostMonster Are Among The Most Reliable Linux Web Hosting Companies In 2014 2Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 2Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 3Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 4Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 2Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 3Health News:New Report Illustrates Extended Mesothelioma Survival with “Maintenance Therapy”, According to Surviving Mesothelioma 2Health News:Researchers Say Antibiotics in Fish a Health Concern 2
... infected with HIV in the UK rose last year to ... not know they are carrying the disease, a report said ... and nearly three-quarters of those were probably contracted in Africa., ... HIV sufferers had risen last year from an estimated 53,000 ...
... of anti-depressant medication and lifestyle change may be it is ... enjoy a splendid ride with a dolphin to help ease ... of biophilia that illustrates the dependence of human health on ... patients with mild to moderate depression were chosen for the ...
... Scientific Advisory Committee on Nutrition in the UK has said ... born with birth defects if folic acid were to be ... reducing commonly found neural tube defects like the spina bifida. ... be avoided if this simple precaution were to be taken. ...
... A new study reveals that antibiotics if taken limitlessly ... more than 10 times during childhood can increase the ... lymphatic system. , The study, conducted by Ellen ... Centre in Fremont, also found heavy use of non-steroidal ...
... its toll on Hong Kong teachers, with one in three ... ,Shouting at students in the class is affecting the ... said dry throats and husky and harsh voices were among ... developed voices like men., ,Researchers claim the problem ...
... Bacteria have been long regarded as something, only capable ... might soon change.// Thanks to the fervent efforts of ... UCSF who have created the first-ever bacterial photographs. ... at promoting the construction of simple biological machines is ...
Cached Medicine News:Health News:Swimming With Dolphins Can Help Ease Depression 2Health News:Bacterial Photographs Created By Student Scientists! 2
(Date:10/25/2014)...  The National Association of Drug Diversion Investigators ... Kentucky,s real-time, stop-sale pseudoephedrine ... Precursor Log Exchange (NPLEx) system automatically blocks unlawful ... helps flag meth offenders for law enforcement. Police ... "watch lists" that notify them via email when ...
(Date:10/25/2014)... , Oct. 24, 2014   Metanome, Inc. , ... metagenomic services and data analysis, was the genomic sequencing ... ) Phase I/II clinical trial of SER 109, an ... Clostridium difficile infections (CDI). Metanome ... Health,s R&D and clinical programs. Such genomic characterization has ...
(Date:10/25/2014)... October 24, 2014 ... has announced the addition of the  "Global ...  report to their offering.  ... Chinese Acne Medication Industry Report 2014 is ... current state of the global acne medication ...
Breaking Medicine Technology:Kentucky's NPLEx Technology Making Significant Progress 2Metanome Selected as Metagenomics Provider for Seres Health Clinical Trial 2Global and Chinese Acne Medication Industry Report 2014 2Global and Chinese Acne Medication Industry Report 2014 3
... , SAN DIEGO, Sept. 11 Calixa ... development and commercialization of novel antibiotics for the treatment ... in 20 posters at the Interscience Conference on Antimicrobial ... San Francisco on September 12 to 15, 2009. ...
... , , , ... preliminary schedule of events at the Cardiovascular Research Foundation,s (CRF) ... September 21st to Friday, September 25th, in San Francisco, CA. ... the world,s largest events for those performing cardiac diagnostics and ...
Cached Medicine Technology:Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 2Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 3Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 4InfraReDx to Showcase the LipiScan(TM) Coronary Imaging System at the Cardiovascular Research Foundation's (CRF) Annual Transcatheter Cardiovascular Therapeutics (TCT) Scientific Meeting 2
... watt halogen light source with ... ,SOLOS Endoscopy shares your commitment ... the highest quality care available ... development of advanced surgical instruments ...
Linvatecs single CCD camera heads offer high resolution with the convenience of programmable buttons for sterile field control of the printer and VCR. Available in "V and "C mount in NTSC and PAL....
... camera system offers the latest technology ... controller. Equipped with many of the ... expensive camera controllers, including edge enhancement, ... The controller is compatible and interchangeable ...
... Camera Systems provide the advanced functionality ... need for advanced training. Programmable, easy ... the flexibility needed to accommodate the ... Compatible with both autoclavable and non-autoclavable ...
Medicine Products: