Navigation Links
New Tool to Watch Real-Time Chemical Activity in Cells

y is turned on or off. The sensor is made from a protein that glows, originally isolated from jellyfish. When PKA is turned off, the biosensor glows blue. When PKA is turned on and is physically close to a biosensor, PKA itself changes the shape of the biosensor, causing it to glow green instead.

Manipulating the sensor allows the researchers to direct it to specific locales within cells. That allows the researchers to see where in the cell the active enzyme is located. So this PKA sensor not only indicates whether the enzyme is on or off, but also locates where PKA is being turned on or off within the cell. “Proteins aren’t spread out evenly in cells,” says Zhang, “but tend to cluster together in order to do specific jobs, and we now can see how different clusters are regulated differently.”

When the researchers put their new sensor into living mammalian cells growing in the lab, they were able to test the effects of 160 different chemicals at once and see if any of these chemicals could turn on or off the PKA enzyme by looking for green or blue glowing cells.

Of the 160 chemicals tested, three caused cells to turn on the switch and two others caused cells to turn off the switch.

The 160 chemicals tested are from the Johns Hopkins Clinical Compound Library, a collection of about 3,300 chemicals. Most of them are drugs already approved by the U.S. Food and Drug Administration, while others are drugs approved by regulatory agencies in other countries or are other clinically relevant chemicals.

“If we can find a new activity for a known drug, this may lead to a new use or a new way of thinking about that drug,” says Zhang, who hopes to test the rest of the chemicals in the collection soon for their ability to interfere with the enzyme tested in this study. Finding a drug that can tame this enzyme could lead to new treatments for heart disease, diabetes, memory disorders and certain cancers, for example.
<
'"/>




Page: 1 2 3

Related medicine news :

1. Watch your weight when pregnant
2. Watching television for long hours could lead to agressiveness
3. Watch what you eat during summer
4. Watch your weight when pregnant
5. Watching television linked to smoking
6. Watching TV in the bedroom can lower children’s school performanc
7. Stop Watching TV: Toddler Development Affected
8. Watch Out! Pollution hazard from E-waste recycling in India & China
9. Watch out those of you planning for a predetermined Cesarean Section
10. For West Nile Virus: Prevention Is The Watchword
11. Watching Violent, Churning Movie Scenes Affect Problem-Solving Ability
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Tool Watch Real Time Chemical Activity Cells

(Date:7/31/2015)... ... July 31, 2015 , ... As part of their company mission, ... of animal welfare organizations is essential to the longevity of their business. It ... National Association of Professional Pet Sitters (NAPPS) annual Presents 4 Pets supply drive. ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... “HARMONY 2015”, one of the industry’s premier thought leadership symposiums, hosted by ... and 6. The event attracts over 250 “C”-level executives, administrators, directors of ...
(Date:7/31/2015)... IL (PRWEB) , ... July 31, 2015 , ... The ... Boston, when Major League Baseball and the Boston Red Sox honor Ice Bucket co-founders ... the challenge. MLB is donating $100,000 to further collaborative efforts among the ALS organizations ...
(Date:7/31/2015)... ... July 31, 2015 , ... Successful Import/Export ... http://www.fdanews.com/importexportprogram , Having FDA-regulated products held at ports costs time, money ... risking containment — or even destruction — of products, an FDA insider shows ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... a blog post that encourages the understanding and treatment of ankle sprains. A ... for in-home remedies. This can be dangerous if the condition augments and causes ...
Breaking Medicine News(10 mins):Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 2Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 3Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 2Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 3Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 4Health News:FDAnews Announces — Successful Import/Export Programs: Former FDA Expert Shows the Way, Oct. 20-21, 2015 2Health News:FDAnews Announces — Successful Import/Export Programs: Former FDA Expert Shows the Way, Oct. 20-21, 2015 3Health News:FDAnews Announces — Successful Import/Export Programs: Former FDA Expert Shows the Way, Oct. 20-21, 2015 4Health News:Absolute PhysioCare & Sports Rehab Promotes Understanding & Treatment of Ankle Sprains 2
... SPRING HARBOR, N.Y. - In a variety ... stem cells have the potential to differentiate into a ... to a complete new organism. Stem cell research, ... biologists--reproductive biologists, cancer biologists, cell and developmental biologists, and ...
... Dermatologists emphasize treatment should be tailored to meet ... Ill., June 4 Based on an extensive review ... recognized psoriasis experts, the American Academy of Dermatology (Academy) ... and treatment of psoriasis with traditional systemic therapies. Recommendations, ...
... 4 Custom Spine announced today that Randal Clarke is ... Randy has been in the orthopedic medical device market ... for new products and building successful start-up organizations. ... representative for Zimmer, which was followed by a sales career ...
... PAUL, Minn., June 4 The Minneapolis-St. Paul office ... Marrow Donor Program to head the organization,s largest annual ... runs June 8-22, will work to reach a diverse ... advocates. For thousands of people with leukemia and other ...
... Pharmacy Management Technology, Will Offer Patients Any-Store Refills , ... LLC has selected PDX and affiliates Rx.com and NHIN as ... , , Albertson,s, LLC is replacing its current ... (EPS), unparalleled in efficiency, safety, and tools for ...
... before the current economic downturn, an American family filed for ... of them were insured. Over 60% of all bankruptcies in ... In an article published in the August 2009 issue of ... the first-ever national random-sample survey of bankruptcy filers shows that ...
Cached Medicine News:Health News:New interdisciplinary volume focuses on advances in stem cell research 2Health News:American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications 2Health News:American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications 3Health News:American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications 4Health News:American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications 5Health News:American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications 6Health News:Custom Spine Welcomes Randal Clarke as Vice President of Sales 2Health News:Weber Shandwick Chosen By National Marrow Donor Program(R) To Head Awareness Campaign 2Health News:Weber Shandwick Chosen By National Marrow Donor Program(R) To Head Awareness Campaign 3Health News:Albertson's, LLC Selects PDX-NHIN-Rx.com to Provide Complete Pharmacy Management Solution 2Health News:Over 60 percent of all US bankruptcies attributable to medical problems 2
(Date:7/30/2015)... 30, 2015  EP Global Communications, Inc. (Public OTC: ... contacted the Company about discussing EPGL,s electronic contact ... Monday, August 3, 2015.  Novartis CEO Joe ... the coming electronic contact lens market could be ... next several years.  Novartis partnered with Google in ...
(Date:7/30/2015)... OAKS, Calif., July 30, 2015  Amgen (NASDAQ: ... the second quarter of 2015. Key results include: ... the second quarter of 2014 to $5,370 million, ... by Enbrel ® (etanercept), Prolia ® ... (carfilzomib) and XGEVA ® (denosumab). Unfavorable changes ...
(Date:7/30/2015)... July 30, 2015  Cleveland Clinic President Wael ... address last month that industry is compelled to adopt ... gain the efficiencies—and develop the transformational innovations -- required ... comments were preceded by Doug Kohrs , past ... moderator, who stressed that industry must add "episode of ...
Breaking Medicine Technology:Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 20Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 21Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 22Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 23Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2
... SAN CARLOS, Calif., June 23, 2011 PharmacoFore, ... abuse-resistant prescription drugs, today announced positive results from ... its hydromorphone (HM) Bio-Activated Molecular Delivery™ (Bio-MD™) product ... will present at the 2011 BIO Business Forum ...
... Today,s U.S. Supreme Court decision in ... safety, giving generic drug companies legal immunity when they ignore ...  This decision eliminates any incentive for generic manufacturers to ensure ... drugs, potential dangers. This decision also means that ...
Cached Medicine Technology:PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 2PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 3PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 4Generic Drug Decision Disastrous to Patient Safety 2
Used for common bile duct exploration. Supplied sterile in peel-open packages. Intended for one-time use....
... with the MAMMOTOME® HH (Hand ... invasive procedure using ultrasound imaging ... images to locate breast abnormalities, ... and map the area you ...
... Provides reliable strength for temporary wound ... which compliant and stretchable support material ... transudate is not required. Predictable absorption. ... be inert, nonantigenic, and nonpyrogenic. ,VICRYL ...
... Mesh plugs perform best when the ... contact with a smooth wall of highly ... means less tissue remodeling to help stabilize ... fills more of the defect with gentle ...
Medicine Products: