Navigation Links
New Therapy for Lipid Disorder Demonstrates Varied Results

Preliminary research suggests that use of a novel, potent drug to treat cholesterol disorders decreases triglycerides and increases// HDL-C, the 'good' cholesterol, but also raises some safety concerns, according to a study.

Several different classes of drugs are used to treat lipid disorders. Fibrates reduce the liver's production of a triglyceride-carrying particle and speed up removal of triglycerides from the blood. Statins reduce cholesterol levels by inhibiting an enzyme that produces cholesterol in the liver. New, more potent and selective medications are being developed to treat lipid disorders within the class of drugs known as peroxisome proliferator-activated receptor (PPAR)-alpha agonists - drugs that turn on one of several cellular switches, according to background information in the article. None of the new PPAR-alpha agonists has achieved regulatory

Steven E. Nissen, M.D., of the Cleveland Clinic Lerner School of Medicine, Cleveland, and colleagues conducted two multi-center, randomized trials to examine the safety and efficacy of a PPAR-alpha agonist known as LY518674. In one study, 309 patients with atherogenic dyslipidemia (elevated triglycerides and low HDL-C) received LY518674 (in one of 4 doses, 10, 25, 50 or 100 micrograms), placebo, or the fibrate drug fenofibrate. In the other study, 304 patients with hypercholesterolemia (elevated LDL-C, the 'bad' cholesterol) received placebo or the statin drug atorvastatin for four weeks, then placebo or LY518674 (in one of 2 doses, 10 or 50 micrograms) for 12 more weeks. The patients were randomized between August 2005 and August 2006.

'Efficacy in an atherogenic dyslipidemia population was generally similar to that of fenofibrate, producing a 35 percent to 42 percent decrease in triglyceride levels and a two percent to 16 percent increase in HDL-C levels,' the authors report.

'In those with hypercholesterolemia, LY518674 reduced triglycerides a nd increased HDL-C, but did not further reduce LDL-C in combination with atorvastatin,' they continue.

In general, both LY518674 and fenofibrate were well tolerated, but the authors report both drugs raised some safety concerns. LY518674 and fenofibrate increased serum creatinine levels among patients with dyslipidemia. In some patients, serum creatinine increased above the upper limit of normal. (Abnormally high levels of creatinine may signal impaired function or failure of the kidneys). Also, LY518674 increased LDL-C in patients with dyslipidemia.

'These drugs modulate activity of a large number of genes, some of which produce unknown effects,' the authors write. 'Accordingly, the beneficial effects of PPAR activation appear to be associated with a variety of untoward effects, which may include oncogenesis [the progression of genetic and cellular changes that culminate in a malignant tumor], renal [kidney] dysfunction, rhabdomyolysis [a condition in which skeletal muscle cells break down] and cardiovascular toxicity.'

The authors believe their findings underscore the importance of prompt and thorough reporting of clinical trials of new pharmaceutical agents.

'Such studies advance the understanding of risks and benefits of new approaches and enable subsequent development programs to refine future study designs. Prompt publication also allows better protection of patient safety by providing study sponsors, investigators, and data and safety monitoring committees with a better appreciation of any potential risks that may require close monitoring,' they conclude.


Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Consensus on "Combination Therapy" for Breast Cancer
3. Gene Therapy shows promise in treating Hemophilia
4. "Make AIDS Therapy affordable" - Physicians demand
5. Hormone replacement Therapy a headache
6. Simple Therapy
7. Therapy for stopping the spread of cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Letrozole Beats Tamoxifen in Breast Cancer Therapy
10. Garlic Supplements Impede HIV Therapy
11. Gene Therapy For Cystic Fibrosis
Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical Officer ... physician colleagues, skilled nursing facility medical directors and other clinicians at various events ... Care." , "At many of these conferences we get to educate other physicians, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... The Rebound mobile app is poised to become ... tide of prescription drug addiction. The app empowers users to ... stepping down their dosage in a safe, controlled manner while ... the first 100,000 people to sign up will enjoy 3 ... ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The Dr. ... ...
Breaking Medicine Technology: